公开(公告)号：EP0775006A1

公开(公告)日：1997-05-28

申请号：EP96920495.0

申请日：1996-05-22

申请人： BAXTER INTERNATIONAL INC.

发明人： BROWN, Richard, I.

IPC分类号： A61M1 ,  B01D17 ,  B01D21 ,  B04B5 ,  B04B7 ,  B04B13

CPC分类号： A61M1/02 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/385 ,  A61M2202/0427 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  A61M2202/0071

摘要： Blood collection systems and methods minimize citrate toxicity in donors. The systems and methods convey whole blood at a prescribed rate Qb into a separation device for separation into red blood cells and a plasma constituent. The systems and methods add anticoagulant including citrate to the whole blood. The systems and methods control Qb (in ml/min or equivalent) based upon a citrate equivalent blood flow rate EqQBCIR, where: where: CIR is a selected nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), AC is a selected anticoagulant ratio, Wgt is the donor's weight (in kg or equivalent), and CitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent).

公开(公告)号：EP0755708A2

公开(公告)日：1997-01-29

申请号：EP96202542.5

申请日：1993-03-23

申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)

发明人： Brown, Richard I.

IPC分类号： B01D21/26 ,  B04B5/04 ,  A61M1/36

CPC分类号： B04B13/00 ,  A61M1/0209 ,  A61M1/025 ,  A61M1/029 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/0003 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/2488 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B2005/045 ,  A61M2202/0071

摘要： The apparatus includes a chamber (10,31A,58,84) having a first wall (16,64) closer to the rotational axis (14,62) than a second wall (18,66). The first wall (16,64) defines a low-G side of a separation zone and the second wall (18,64) defines a high-G side of the zone. Whole blood enters a zone entry region to separate red cells toward the high-G side and platelet rich plasma (PRP) toward the low-G side. Blood flows through an inlet port (20,68) into the entry region while PRP is collected from the low-G side of the zone in the entry region through an outlet port (24,72). This enhances PRP yields.

公开(公告)号：EP0319961B1

公开(公告)日：1996-03-20

申请号：EP88120473.9

申请日：1988-12-07

申请人： JAPAN IMMUNO RESEARCH LABORATORIES CO., LTD. ,  SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA

发明人： Adachi, Masakazu ,  Nakatani, Masahiro ,  Honda, Seiichirou

IPC分类号： A61M1/36

CPC分类号： A61M1/3679 ,  A61M2202/0413 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0433 ,  A61M2202/0439 ,  A61M2202/0441 ,  A61M2230/005 ,  A61M2202/005 ,  A61M2202/0057 ,  A61M2202/0064

公开(公告)号：EP0530688B1

公开(公告)日：1995-11-29

申请号：EP92114687.4

申请日：1992-08-28

申请人： Fresenius AG

发明人： Biesel, Wolfgang, Dr. ,  Geibel, Johannes ,  Brass, Henning

IPC分类号： A61M1/36 ,  B01D43/00

CPC分类号： B01D43/00 ,  A61M1/3693 ,  A61M2202/0427 ,  A61M2202/0429 ,  Y10S210/929

公开(公告)号：EP0666771A1

公开(公告)日：1995-08-16

申请号：EP94917252.0

申请日：1994-02-14

申请人： BAXTER INTERNATIONAL INC.

发明人： BROWN, Richard, I.

IPC分类号： A61M1 ,  A61K35 ,  B01D17 ,  B01D21 ,  B01D37 ,  B04B5 ,  B04B13

CPC分类号： B04B13/00 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/08 ,  B01D2221/10 ,  B04B5/0442 ,  A61M2202/0071

摘要： Systems and methods for collecting cellular-rich concentrates of blood are disclosed. Blood from donor (78) is mixed with anticoagulant (90) and conveyed to a first separation device (12) for separating an anticoagulated cellular suspension from blood. The anticoagulated cellular suspension is conveyed to a second separation device (14) for removing leukocytes. Leukocyte-depleted cellular suspension is conveyed to a third separation device (16) for concentrating the leukocyte-depleted cellular suspension into a cellular-rich concentrate and a cellular-poor component and a portion of the cellular-poor component is returned to the donor (78). A controller (88) is used to control the process including monitoring the rate at which anticoagulant carried in the cellular-poor component is being infused with the returned cellular-poor component into the donor (78).

公开(公告)号：EP0662857A1

公开(公告)日：1995-07-19

申请号：EP94913269.0

申请日：1994-02-14

申请人： BAXTER INTERNATIONAL INC.

发明人： BROWN, Richard, I.

IPC分类号： A61K35 ,  A61M1 ,  B01D21 ,  B01D37 ,  B01D61 ,  B04B5

CPC分类号： B01D21/302 ,  A61M1/0218 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  B01D21/262 ,  B01D2221/08 ,  B01D2221/10 ,  B04B5/0442 ,  A61M2202/0071

摘要： Systems and methods are provided for reducing the number of leukocytes in cellular products like platelets collected in an on-line or continuous blood separation processes. The systems include first separation element (12) for separating blood into a suspension of platelets, second separation element (14) for reducing the number of leukocytes in a suspension of platelets, third separation element (16) for separating a suspension of platelets into a platelet-rich concentrate and a control means for operating separation elements (12, 14, 16) in various modes. The methods for obtaining a high quality blood product suited for therapeutic use are disclosed.

公开(公告)号：EP0661064A1

公开(公告)日：1995-07-05

申请号：EP95200222.8

申请日：1991-06-12

申请人： BAXTER INTERNATIONAL INC.

发明人： Hwang, Yean Yow ,  Ritchey, Brian ,  Schoendorfer, Donald W.

IPC分类号： A61M1/36

CPC分类号： A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3646 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427

摘要： Whole blood is separated into components in a separator (46) to produce platelet-rich plasma in a first operation in which a low amount of anticoagulant is added to the whole blood sufficient to prevent coagulation. Further anticoagulant is passed through the separator (46) after the whole blood flow has been stopped, so as to add further anticoagulant to the platelet-rich plasma to promote storage. This permits a higher platelet yield to be obtained in the separator.

摘要翻译： 在第一次操作中，将全血分离成分离器（46）中的组分以产生富含血小板的血浆，其中少量的抗凝血剂被添加到足以防止凝血的全血中。 在全血流已经停止之后，进一步的抗凝血剂通过分离器（46），以便进一步增加血小板富集血浆的抗凝血剂以促进储存。 这允许在分离器中获得较高的血小板产量。

公开(公告)号：EP0618831A4

公开(公告)日：1995-03-29

申请号：EP93912083

申请日：1993-03-23

申请人： BAXTER INT

发明人： BROWN RICHARD I

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/00 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

CPC分类号： B04B13/00 ,  A61M1/0209 ,  A61M1/025 ,  A61M1/029 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/0003 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/2488 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B2005/045 ,  A61M2202/0071

摘要： A centrifugal separation apparatus for separating whole blood into red blood cells and a plasma constituent carrying platelets is described. The apparatus comprises a separation chamber (10, 31A, 58) which has first and second spaced apart walls (16, 18, 64, 66) that form a separation zone (84) having a low-G side and a high-G side that is located radially further from the rotational axis than the low-G side. The separation zone includes an entry region (122) where the whole blood enters the separation chamber to begin separation into red blood cells toward the high-G side and the plasma constituent toward the low-G side. Inlet and outlet openings (20, 68, 24, 72) are provided that communicate with the separation chamber. The inlet opening provides for the introduction of whole blood into the entry region. The outlet opening (24, 72) directs the plasma constituent from a plasma constituent collection region (124) at the low-G side of the separation zone adjacent the entry region while whole blood is introduced into the entry region through the inlet opening. The apparatus also comprises an interface control system (134) that is located outside the separation chamber and is arranged to monitor the location of an interface (26) that forms between the red blood cells and the plasma constituent during separation by viewing into the separation zone. A method for centrifugally separating whole blood into red blood cells and a plasma constituent carrying platelets is also described.

公开(公告)号：EP0419346B1

公开(公告)日：1995-02-01

申请号：EP90402574.9

申请日：1990-09-18

申请人： TERUMO KABUSHIKI KAISHA

发明人： Kuroki, Hitoshi, ,  Kuroda, Shinichiro,

IPC分类号： B01D39/16 ,  A61M5/165

CPC分类号： B01D39/1676 ,  A61M2202/0427 ,  A61M2202/0439 ,  A61M2202/0042 ,  A61M2202/0057

公开(公告)号：EP0491850A1

公开(公告)日：1992-07-01

申请号：EP90914818.0

申请日：1990-09-11

申请人： PALL CORPORATION

发明人： PALL, David, B. ,  GSELL, Thomas, C. ,  MUELLERS, Brian, T.

IPC分类号： A61M1 ,  A61K35 ,  B01D35 ,  B01D39

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M1/3633 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2202/0439 ,  B01D39/1623 ,  A61M2202/0071 ,  A61M2202/005 ,  A61M2202/0057

摘要： Un dispositif de traitement de sang d'un donneur comprend un milieu poreux interposé entre le sac de collecte (11) et un sac satellite (13) dans lequel un composant séparé par centrifugation peut être exprimé, l'élément de filtre ayant de préférence une tension de surface humide critique d'environ 70 à environ 115 dynes/cm. Le milieu poreux bloque les globules rouges, mais permet le passage des plaquettes.