公开(公告)号：EP0804233A1

公开(公告)日：1997-11-05

申请号：EP94922473.0

申请日：1994-07-12

申请人： SOLVAY ANIMAL HEALTH, INC.

发明人： PETERSEN, Gary Ralph ,  WELNIAK, Ellan ,  VAN WILTENBURG, Nico

IPC分类号： C12N5 ,  A61K39 ,  A61P31 ,  C12N7

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/235 ,  A61K39/245 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/552 ,  C12N2710/10151 ,  C12N2710/16034 ,  C12N2710/16051 ,  C12N2710/16334 ,  Y10S424/816

摘要： Infectious laryngotracheitis virus (ILTV) and egg drop syndrome virus (EDS) production are currently cultivated in either primary cell cultures or in chicken embryos. These production practices are both costly and difficult. Until now no continuous cell line has been identified which is capable of supporting either ILTV or EDS replication. This invention involves the discovery that a chemically transformed chicken hepatocyte derived cell line is capable of efficiently supporting replication of both ILTV and EDS. Titers of virus harvested from cell culture are sufficient to allow conversion of production from chicken embryo or primary cell culture to continuous cell culture methods.

公开(公告)号：EP0332241B1

公开(公告)日：1995-01-04

申请号：EP89200382.3

申请日：1989-02-17

申请人： Akzo Nobel N.V.

发明人： Schrier, Carla Christina

IPC分类号： A61K39/295 ,  A61K39/215

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/541 ,  A61K2039/544 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2710/16034 ,  C12N2760/18134 ,  C12N2770/20034 ,  Y10S424/816

公开(公告)号：EP0332241A3

公开(公告)日：1990-05-16

申请号：EP89200382.3

申请日：1989-02-17

申请人： Akzo Nobel N.V.

发明人： Schrier, Carla Christina

IPC分类号： A61K39/295 ,  A61K39/215

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/541 ,  A61K2039/544 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2710/16034 ,  C12N2760/18134 ,  C12N2770/20034 ,  Y10S424/816

摘要： The present invention is concerned with live com­bined vaccines for immunizing poultry comprising at least two different viruses, wherein at least one of the viruses is an infectious bronchitis virus showing the property of spontaneously hemagglutinating chicken erythrocytes.

公开(公告)号：EP2710137B1

公开(公告)日：2018-09-19

申请号：EP12755115.8

申请日：2012-03-09

申请人： Provectus Pharmatech, Inc. ,  Pfizer Inc.

发明人： EAGLE, Craig J. ,  DEES, H. Craig ,  WACHTER, Eric A. ,  SINGER, Jamie

IPC分类号： A61K31/352 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/3955 ,  A61K31/352 ,  A61K31/365 ,  A61K38/193 ,  A61K38/20 ,  A61K38/2006 ,  A61K38/2013 ,  A61K38/204 ,  A61K38/21 ,  A61K38/212 ,  A61K38/217 ,  A61K39/0005 ,  A61K39/0011 ,  A61K39/245 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/02 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/30 ,  C12N7/00 ,  C12N2710/16021 ,  C12N2710/16034

摘要： A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic immunomodulatory anticancer agent. A further method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic targeted anticancer agent. The present invention is further directed to pharmaceutical compositions for treatment of cancer. The intralesional chemoablative pharmaceutical composition can comprise an IL chemoablative agent comprising primarily a halogenated xanthene.

公开(公告)号：EP3336096A1

公开(公告)日：2018-06-20

申请号：EP17201202.3

申请日：2012-12-11

申请人： The Trustees of The University of Pennsylvania

发明人： WEINER, David B. ,  MORROW, Matthew P. ,  YAN, Jian

IPC分类号： C07H15/24 ,  C12N15/67

CPC分类号： A61K39/39 ,  A61K38/20 ,  A61K38/208 ,  A61K38/2086 ,  A61K39/0005 ,  A61K39/0011 ,  A61K39/245 ,  A61K39/292 ,  A61K41/00 ,  A61K2039/525 ,  A61K2039/53 ,  A61K2039/55538 ,  C07K14/5434 ,  C12N7/00 ,  C12N2510/00 ,  C12N2710/16034 ,  C12N2730/10134 ,  C12N2730/10171

摘要： Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL-12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed .

公开(公告)号：EP3200821A4

公开(公告)日：2018-03-14

申请号：EP15846188

申请日：2015-10-01

申请人： ADMEDUS VACCINES PTY LTD

发明人： DUTTON JULIE ,  FRAZER IAN

IPC分类号： A61K39/245 ,  A61P31/22 ,  C07H21/04

CPC分类号： A61K39/12 ,  A61K2039/572 ,  C12N2710/16022 ,  C12N2710/16034

摘要： Disclosed are therapeutic compositions and methods for inducing an immune response to herpes simplex virus type 2 (HSV-2). More particularly, the invention relates to a method for inducing an immune response in a subject by introducing and expressing an HSV gD2-encoding DNA vaccine.

公开(公告)号：EP3227433A1

公开(公告)日：2017-10-11

申请号：EP15805147.4

申请日：2015-12-03

申请人： Intervet International B.V.

发明人： KOOL, Jaap

IPC分类号： C12N5/071 ,  C12N7/00

CPC分类号： C12N7/08 ,  A61K39/12 ,  C12N7/00 ,  C12N7/02 ,  C12N15/79 ,  C12N2330/51 ,  C12N2510/02 ,  C12N2510/04 ,  C12N2710/16034 ,  C12N2710/16351

摘要： The present invention relates to immortalised chicken embryo fibroblasts, to cell cultures comprising such immortalised cells, to vaccines comprising such cells, to methods for the propagation of avian viruses on such cells, and to methods for the preparation of such cells and such vaccines.

摘要翻译： 本发明涉及永生化鸡胚成纤维细胞，含有这种永生化细胞的细胞培养物，含有这种细胞的疫苗，涉及在这些细胞上繁殖禽类病毒的方法，以及制备这种细胞和这种疫苗的方法。

公开(公告)号：EP2996719A1

公开(公告)日：2016-03-23

申请号：EP14729191.8

申请日：2014-05-12

申请人： Zoetis Services LLC

发明人： DOMINOWSKI, Paul, Joseph ,  RAI, Sharath, K. ,  SLY, Laurel, Mary ,  COOK, Corey, Patrick ,  MWANGI, Duncan ,  FOSS, Dennis, L. ,  KREBS, Richard, Lee

IPC分类号： A61K39/39 ,  A61K39/008 ,  A61K39/27

CPC分类号： A61K39/39 ,  A61K39/008 ,  A61K39/12 ,  A61K39/27 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55577 ,  C12N2710/16034 ,  C12N2710/16734

摘要： The invention provides a vaccine composition comprising an antigen component and an adjuvant component, wherein the adjuvant component comprises a P-class immunostimulatory oligonucleotide and either a combination of a saponin and a sterol; or an oily phase comprising an oil and, optionally, one or more emulsifiers, said oily phase comprising 2-20% v/v of the vaccine composition, wherein said antigen component is an EHV antigen or a Leishmania antigen.

摘要翻译： 本发明提供一种疫苗组合物，其包含抗原成分和佐剂成分，其中所述佐剂成分包含P级免疫刺激性寡核苷酸和皂角苷与固醇的组合; 或包含油和任选的一种或多种乳化剂的油相，所述油相包含2-20％v / v的疫苗组合物，其中所述抗原组分是EHV抗原或利什曼原虫抗原。

公开(公告)号：EP2983703A1

公开(公告)日：2016-02-17

申请号：EP14715511.3

申请日：2014-03-13

申请人： Zoetis Services LLC

发明人： BOWERSOCK, Terry Lynn ,  DUNN, Ryan N. ,  LEYH, Randy Dean ,  OKKINGA, Klaas

IPC分类号： A61K39/102

CPC分类号： A61K39/0208 ,  A61K39/102 ,  A61K39/12 ,  A61K39/155 ,  A61K39/265 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16034 ,  C12N2710/16734 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2770/24334

摘要： The invention provides a method of protecting a bovine susceptible to
Bibersteinia trehalosi , the method comprising administering to said bovine an effective amount of a vaccine comprising a
Mannheimia haemolytica antigen, and further comprising one or more of Infectious Bovine Rhinotracheitis Virus, Bovine Viral Diarrhea Virus, Parainfluenza-3 Virus, and Bovine Respiratory Syncytial Virus.

公开(公告)号：EP2454374B1

公开(公告)日：2016-02-10

申请号：EP10800409.4

申请日：2010-07-13

申请人： Vaxgene Corporation

发明人： LAM, Dominic, Man-Kit ,  XU, Yuhong

IPC分类号： C12N15/74

CPC分类号： C12N15/746 ,  A61K39/12 ,  A61K39/145 ,  A61K2035/122 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/542 ,  A61K2039/70 ,  C12N15/8258 ,  C12N2710/16034 ,  C12N2720/10034 ,  C12N2760/16134 ,  C12N2770/10034 ,  C12N2770/20034 ,  C12N2770/24234 ,  C12N2770/24334

摘要： The anti-pathogen vaccine of the present invention is produced in recombinant bacteria and/or transgenic plants and then administered through standard vaccine introduction method or through the oral administration. A DNA sequence encoding for the expression of an antigen of a pathogen is isolated and ligated to a promoter which can regulate the production of the surface antigen in a bacterial or transgenic plant. Preferably, a foreign gene is expressed in a portion of the plant or bacteria, and all or part of the antigen expressing plant or bacteria used for vaccine administration. In a preferred procedure, the vaccine is administered through the consumption of the edible plant as food, or the bacteria administered orally. The present invention also provides a method of using genetically modified microorganisms generally recognized to be edible and/or harmless to animals or humans when ingested, such as lactic acid bacteria, including Lactococcus lactis strains, as oral vaccines. In one embodiment, Lactococcus lactis expressing the avian influenza HA gene can be used as an oral vaccine for protection against H5N1 virus infection.