公开(公告)号：EP4412979A1

公开(公告)日：2024-08-14

申请号：EP22797572.9

申请日：2022-10-04

申请人： Juva Life, Inc.

发明人： GANGWAR, Sanjeev ,  MILLER, Guy

IPC分类号： C07C50/28 ,  C07C69/16 ,  C07C225/20 ,  A61K31/122 ,  C07C43/23 ,  C07C49/753 ,  C07C69/28 ,  C07C69/30 ,  C07C69/18 ,  A61K31/12

CPC分类号： C07C50/28 ,  C07C49/753 ,  C07C43/23 ,  C07C69/16 ,  C07C69/18 ,  C07C69/28 ,  C07C69/30 ,  C07C2601/1620170501 ,  C07C225/20 ,  C07C225/28

公开(公告)号：EP3402851A1

公开(公告)日：2018-11-21

申请号：EP17738828.7

申请日：2017-01-11

申请人： E Ink California, LLC

发明人： SHAO, Lin ,  GU, Haiyan ,  SOFIYEV, Vladimir ,  WANG, Ming

IPC分类号： C09D5/44 ,  C07C69/18

CPC分类号： C07C69/34 ,  C07C69/33 ,  G02F1/167 ,  G02F2001/1678

摘要： Additives for electrophoretic media comprising esters of branched polyols and fatty acids, such as esters of pentaerythritol propoxylate (5/4 PO/OH) and stearic acid. The fatty acids may be saturated or unsaturated, branched or unbranched. In some embodiments, the fatty acids are perfluorinated, or partially fluorinated. In some embodiments, the branched polyol will include oligomers of polypropylene oxide or polyethylene oxide. When the additives are included in an electrophoretic medium in a display, the resulting display has an improved contrast ratio and reducing ghosting.

公开(公告)号：EP2674413B1

公开(公告)日：2017-06-07

申请号：EP12172191.4

申请日：2012-06-15

申请人： SciPharm SàRL

发明人： Jain, Nareshkumar, F. ,  Kirkup, Michael, P. ,  Marella, Michael, A. ,  Ghone, Sanjeevani, A.

IPC分类号： C07C67/29 ,  C07C69/18 ,  C07F7/18 ,  C12P41/00 ,  C07C47/565 ,  C07C47/575 ,  C07C51/377 ,  C07C59/72 ,  C12P31/00

CPC分类号： C07C51/377 ,  C07C47/565 ,  C07C47/575 ,  C07C59/72 ,  C07C2603/14 ,  C07F7/18 ,  C07F7/1844 ,  C07F7/1852 ,  C07F7/1892 ,  C12P31/00 ,  C12P41/002 ,  C12P41/004

公开(公告)号：EP2861554A2

公开(公告)日：2015-04-22

申请号：EP13724809.2

申请日：2013-05-22

申请人： SciPharm SàRL

发明人： JAIN, Nareshkumar F. ,  KIRKUP, Michael P. ,  MARELLA, Michael A. ,  GHONE, Sanjeevani, A.

IPC分类号： C07C67/29 ,  C07C69/18 ,  C07F7/18 ,  C12P41/00 ,  C07C47/565 ,  C07C47/575 ,  C07C51/377 ,  C07C59/72

CPC分类号： C07C51/377 ,  C07C47/565 ,  C07C47/575 ,  C07C59/72 ,  C07C2603/14 ,  C07F7/18 ,  C07F7/1844 ,  C07F7/1852 ,  C07F7/1892 ,  C12P31/00 ,  C12P41/002 ,  C12P41/004

摘要： A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant improvement of the described method over prior methods is the regioselective Claisen rearrangement of a 5-allyloxy-benzaldehyde precursor, which is facilitated by a bromo substituent in 2-position.

摘要翻译： 描述了曲前列素及其衍生物的制备方法。 与现有技术相比，该方法利用了用于制备这些化合物的关键中间体的易于扩展的酶解析。 所述方法与现有方法的另一显着改进是5-烯丙氧基 - 苯甲醛前体的区域选择性Claisen重排，其由2-位上的溴取代基促进。

公开(公告)号：EP2714643A1

公开(公告)日：2014-04-09

申请号：EP12793877.7

申请日：2012-03-30

申请人： R. J. Reynolds Tobacco Company

发明人： DUBE, Michael Francis ,  COLEMAN, William

IPC分类号： C07C69/18 ,  C07C67/48 ,  C07B63/00

CPC分类号： A24B15/12 ,  A24B15/10 ,  A24B15/24 ,  A24B15/30 ,  A24B15/302 ,  C07C29/095 ,  C07C51/09 ,  C07C67/08 ,  C07C69/34 ,  C07C31/225 ,  C07C69/18 ,  C07C53/08

摘要： A method for producing triacetin from one or more plants of genus Nicotiana is provided. The triacetin can be derived inter alia from Nicotiana species biomass or from seed. In certain embodiments, the triacetin is produced by condensation of glycerin, generated by hydrolysis of acylglycerol-containing starting material derived from tobacco biomass or seed, and acetic acid, also derived from tobacco biomass or seed. The invention also provides articles and compositions including tobacco articles and tobacco compositions that include triacetin produced from one or more plants of genus Nicotiana.

公开(公告)号：EP2448906A1

公开(公告)日：2012-05-09

申请号：EP10734815.3

申请日：2010-06-29

申请人： Rhodia Poliamida E Especialidades Ltda

发明人： SCHUCH, Maria, Cristina ,  IACOVONE, Aires

IPC分类号： C07C67/08 ,  C07C69/18

CPC分类号： C07C67/08 ,  C07C69/18

摘要： The present invention concerns an optimized process to obtain a mixture of lower carboxylic acid mono, di and triesters, from raw glycerin, a by-product of the process to obtain biodiesel, a transesterification of vegetable raw material with lower alcohols. The invention particularly refers to an optimized process to obtain triacetin or a mixture of mono-, di- and triacetin from that raw glycerin, without prior purification.

公开(公告)号：EP1270584B1

公开(公告)日：2005-12-07

申请号：EP01912380.1

申请日：2001-03-15

申请人： Kissei Pharmaceutical Co., Ltd.

发明人： FUJIKURA, Hideki ,  FUSHIMI, Nobuhiko ,  NISHIMURA, Toshihiro ,  TATANI, Kazuya ,  KATSUNO, Kenji ,  HIRATOCHI, Masahiro ,  TOKUTAKE, Yoshiki, Foresu-Azumino C101 ,  ISAJI, Masayuki

IPC分类号： C07H15/203 ,  A61K31/7034 ,  A61P43/00 ,  A61P3/10 ,  A61P3/04 ,  C07C69/78 ,  C07C69/16 ,  C07C69/18 ,  C07C323/18 ,  C07C39/15 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Glucopyranosyloxybenzylbenzene derivatives of the general formula (I) and salts thereof, which exhibit excellent human SGLT2 inhibiting activity and are useful as preventive or therapeutic drugs for diabetes, obesity and so on; and intermediates for the preparation of the derivatives wherein R is hydrogen or hydroxylated lower alkyl; R is lower alkyl, lower alkoxy, lower alkylthio, hydroxylated lower alkyl, hydroxylated lower alkoxy, hydroxylated lower alkylthio, or the like.

公开(公告)号：EP1056704B1

公开(公告)日：2003-05-02

申请号：EP99907161.6

申请日：1999-02-19

申请人： The Regents of the University of California

发明人： MCMORRIS, Trevor, C. ,  KELNER, Michael, J.

IPC分类号： C07C49/497 ,  C07C49/517 ,  C07C69/16 ,  C07C69/18 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07D207/16 ,  C07K5/065 ,  A61K31/12 ,  A61K31/16 ,  A61K31/195 ,  A61K31/25 ,  A61K38/05

CPC分类号： C07C69/013 ,  A61K38/00 ,  C07C49/737 ,  C07C49/753 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07D207/16 ,  C07K5/0215 ,  C07K5/081 ,  C07K5/1013 ,  Y02A50/395

摘要： The present invention provides illudin analogs of the general formula I:wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula I, intermediates and processes useful for preparing compounds of formula I, and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula I.

公开(公告)号：EP1270584A4

公开(公告)日：2003-04-09

申请号：EP01912380

申请日：2001-03-15

申请人： KISSEI PHARMACEUTICAL

发明人： FUJIKURA HIDEKI ,  FUSHIMI NOBUHIKO ,  NISHIMURA TOSHIHIRO ,  TATANI KAZUYA ,  KATSUNO KENJI ,  HIRATOCHI MASAHIRO ,  TOKUTAKE YOSHIKI ,  ISAJI MASAYUKI

IPC分类号： A61K31/7034 ,  A61P3/04 ,  A61P3/10 ,  A61P43/00 ,  C07C39/04 ,  C07C69/16 ,  C07C69/18 ,  C07C69/78 ,  C07C323/18 ,  C07H15/203 ,  A61K31/70 ,  C07C39/15

CPC分类号： C07H15/203

摘要： Glucopyranosyloxybenzylbenzene derivatives of the general formula (I) and salts thereof, which exhibit excellent human SGLT2 inhibiting activity and are useful as preventive or therapeutic drugs for diabetes, obesity and so on; and intermediates for the preparation of the derivatives wherein R is hydrogen or hydroxylated lower alkyl; R is lower alkyl, lower alkoxy, lower alkylthio, hydroxylated lower alkyl, hydroxylated lower alkoxy, hydroxylated lower alkylthio, or the like.

摘要翻译： 通式（I）的吡喃葡萄糖基氧基苄基苯衍生物及其盐，其显示优异的人SGLT2抑制活性，并可用作糖尿病，肥胖等的预防或治疗药物; 和用于制备其中R 1是氢或羟基化的低级烷基的衍生物的中间体; R 2是低级烷基，低级烷氧基，低级烷硫基，羟基化的低级烷基，羟基化的低级烷氧基，羟基化的低级烷硫基等。

公开(公告)号：EP0348764B1

公开(公告)日：1994-06-01

申请号：EP89111037.1

申请日：1989-06-19

申请人： BASF Aktiengesellschaft

发明人： Fischer, Rolf, Dr.

IPC分类号： C07C69/18 ,  C07C67/293

CPC分类号： C07C67/293 ,  C07C69/18