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公开(公告)号：EP3601261A1
公开(公告)日：2020-02-05
申请号：EP18777788.3
申请日：2018-03-30
IPC分类号： C07D401/14 , C12Q1/37
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公开(公告)号：EP3600372A1
公开(公告)日：2020-02-05
申请号：EP18774902.3
申请日：2018-03-07
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63.发明公开
公开(公告)号：EP3600323A1
公开(公告)日：2020-02-05
申请号：EP18775932.9
申请日：2018-03-30
发明人： LYNN, Rachel , MACKALL, Crystal , WEBER, Evan , MALHOTRA, Sanjay
IPC分类号： A61K31/497 , A61P43/00
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公开(公告)号：EP3589750A1
公开(公告)日：2020-01-08
申请号：EP18760612.4
申请日：2018-02-20
IPC分类号： C12Q1/68 , G01N33/542
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公开(公告)号：EP3581580A1
公开(公告)日：2019-12-18
申请号：EP19156461.6
申请日：2015-03-27
IPC分类号： C07K14/405 , A61N5/06 , C07K1/00 , C07K14/00 , C07K17/00 , C12N15/00 , C12N5/071 , A61K41/00
摘要： Aspects of the disclosure include compositions, devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering light-responsive polypeptides, or nucleic acids encoding same, to target cells. The subject compositions and systems include light-activated polypeptides, nucleic acids comprising nucleotide sequences encoding these polypeptides, as well as expression systems that facilitate expression of these polypeptides in target cells. Also provided are methods of using the subject devices and systems to optogenetically manipulate action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or animal subject.
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66.发明公开
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67.发明公开
公开(公告)号：EP3553177A1
公开(公告)日：2019-10-16
申请号：EP19156536.5
申请日：2014-03-14
摘要： Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention.
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公开(公告)号：EP3185013B1
公开(公告)日：2019-10-09
申请号：EP17151969.7
申请日：2010-12-01
发明人： SARWAL, Minnie M. , Li, Li
IPC分类号： C12Q1/6883 , C12Q1/6888
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公开(公告)号：EP3536709A1
公开(公告)日：2019-09-11
申请号：EP19166334.3
申请日：2014-02-26
发明人： WILLINGHAM, Stephen , HOWARD, Maureen , LIU, Jie , MAJETI, Ravindra , PROHASKA, Susan Sweeney , VOLKMER, Anne K. , VOLKMER, Jens-Peter , WEISSMAN, Irving L.
摘要： Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject. Turnover of cells begins with the induction of an apoptotic program or other cellular changes that mark them for removal, and the subsequent recognition of markers by phagocytes, including macrophages, dendritic cells, and the like. This process requires a specific and selective removal of unwanted cells.
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公开(公告)号：EP3532497A1
公开(公告)日：2019-09-04
申请号：EP17865245.9
申请日：2017-10-26
发明人： LIU, Jie , WEISSMAN, Irving L. , MAJETI, Ravindra
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