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公开(公告)号：EP1434590A4
公开(公告)日：2005-11-02
申请号：EP02795514
申请日：2002-10-09
申请人： ZYMOGENETICS INC
发明人： BISHOP PAUL D , GROSSMANN ANGELIKA
IPC分类号： A61K38/43 , A61K38/45 , A61K38/48 , A61P17/02 , A61K31/74 , A61F2/00 , A61K9/50 , A61K35/14 , C12Q1/56
CPC分类号： A61K38/45 , A61K38/4833 , A61K2300/00
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公开(公告)号：EP1576112A3
公开(公告)日：2005-10-26
申请号：EP03761891.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N1/00
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63.发明公开
公开(公告)号：EP1575609A2
公开(公告)日：2005-09-21
申请号：EP03777830.5
申请日：2003-10-23
申请人： ZymoGenetics, Inc.
CPC分类号： A61K47/48215 , A61K38/20 , A61K38/21 , A61K47/60 , C07K14/54 , Y02A50/385 , Y02A50/393
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
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公开(公告)号：EP1558287A2
公开(公告)日：2005-08-03
申请号：EP03773168.4
申请日：2003-10-07
申请人： ZymoGenetics, Inc.
IPC分类号： A61K39/395 , A61K49/00
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.
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公开(公告)号：EP1133564B1
公开(公告)日：2004-08-04
申请号：EP99965810.7
申请日：1999-11-15
申请人： ZymoGenetics, Inc.
发明人： SHEPPARD, Paul, O.
CPC分类号： C12N9/6489 , C07K2319/00
摘要： Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin II from angiotensin I, and the inactivation of the vasodilatory peptide bradykinin. Zace1 is a form of human zinc metallopeptidas, which includes one zinc-dependent catalytic domain containing the motif 'HEXXH' and one downstream 'EX(I/V)X(D/S)' motif.
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公开(公告)号：EP1399472A4
公开(公告)日：2004-06-30
申请号：EP02713823
申请日：2002-03-07
申请人： ZYMOGENETICS INC
IPC分类号： C12N15/09 , A61K38/00 , A61P11/00 , A61P17/06 , A61P29/00 , C07K14/715 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C07K14/00
CPC分类号： C07K14/7155 , C07K2319/00
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公开(公告)号：EP1032671B1
公开(公告)日：2004-06-23
申请号：EP98960493.9
申请日：1998-11-25
申请人： ZymoGenetics, Inc.
CPC分类号： C07K14/54 , A01K67/027 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/52 , C12N2799/021
摘要： A mammalian cytokine-like polypeptide, called Zcyto10, polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.
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68.发明授权COMPOSITION FOR INHIBITING INTIMAL HYPERPLASIA USING PDGF ANTAGONISTS AND HEPARIN 失效成分用于抑制增生INNER使用PDGF拮抗剂和肝素
公开(公告)号：EP0801572B1
公开(公告)日：2004-05-19
申请号：EP95944642.8
申请日：1995-12-20
IPC分类号： A61K31/715 , A61K39/395
CPC分类号： A61K31/727 , A61K38/00 , A61K39/395 , C07K16/2863 , C07K2317/24 , C07K2317/73 , C07K2319/00 , A61K2300/00
摘要： Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise coordinately administering to the mammal a PDGF antagonist and heparin. The antagonist can be a non-peptidic antagonist or an anti-PDGF receptor antibody, such as an anti-PDGF-alpha receptor antibody or an anti-PDGF-beta receptor antibody. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft.
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公开(公告)号：EP1416947A1
公开(公告)日：2004-05-12
申请号：EP02750240.0
申请日：2002-07-23
申请人： ZymoGenetics, Inc.
发明人： ZAMOST, Bruce, L.
IPC分类号： A61K35/72 , A61K38/00 , A61K38/16 , A61K38/36 , A61K38/37 , C07K1/00 , C12N1/00 , C12N1/14 , C12N1/16 , C12N1/18 , C12P1/00 , C12P1/02 , C12P21/00
CPC分类号： C12N1/18 , C07K14/755
摘要： A yeast fermentation medium that does not contain yeast cell extract but is comprised of a mixture of oleic acid, lactic acid and palmitic acid. Using this fermentation medium yields of factor XIII were increased 250 %.
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70.发明授权4-(2-(N-2-CARBOXAMIDOINDOLE)AMINOETHYL)-BENZENESULFONAMIDES OR SULFONYLUREAS AS PDGF ANTAGONISTS 失效作为PDGF拮抗剂的4-（2-（N-2-羧基氨基吲哚）氨基乙基）苯磺酰胺或磺酰脲类
公开(公告)号：EP0835115B1
公开(公告)日：2004-05-06
申请号：EP96916719.6
申请日：1996-05-29
申请人： ZymoGenetics, Inc.
IPC分类号： A61K31/64 , A61K31/40 , A61K31/404 , A61P9/10
CPC分类号： A61K31/454 , A61K31/4045 , A61K31/64
摘要： Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal a non-peptide PDGF antagonist such as 4-(2-(N-2-carboxamidoindole)aminoethyl)-benzenesulfonamides or sulfonylureas. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. The non-peptide PDGF antagonists may optionally be administered coordinately with heparin, whereby the coordinately administration of non-peptide PDGF antagonist and heparin are combinatorially effective in inhibiting intimal hyperplasia.
摘要翻译： 公开了用于抑制包括灵长类在内的哺乳动物脉管系统内膜增生的方法。 所述方法包括对哺乳动物施用非肽PDGF拮抗剂例如4-（2-（N-2-甲酰氨基吲哚）氨基乙基）苯磺酰胺或磺酰脲。 该方法可用于减少由于例如血管成形术，内膜切除术，减动脉粥样硬化斑块切除术或血管移植物的吻合术引起的血管损伤引起的内膜增生。 非肽类PDGF拮抗剂可以任选地与肝素配位给药，由此非肽类PDGF拮抗剂和肝素的协调给药在抑制内膜增生方面是组合有效的。
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