公开(公告)号：EP1339458B1

公开(公告)日：2007-08-15

申请号：EP01997301.5

申请日：2001-11-20

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： WOOD, Jeanette, Marjorie ,  BRANDT, Ralf ,  BOLD, Guido ,  TRAXLER, Peter

IPC分类号： A61P35/00 ,  A61K45/06 ,  A61K31/505 ,  A61K31/70

CPC分类号： A61K45/06 ,  A61K31/505 ,  A61K31/70 ,  A61K31/50 ,  A61K31/335 ,  A61K2300/00

摘要： The invention relates to a combination which comprises a first active ingredient which is a vasculostatic compound and a second active ingredient which decreases the activity of the epidermal growth factor (EGF), in particular, for the delay of progression or treatment of a disease associated with deregulated angiogenesis, especially a proliferative disease; a pharmaceutical composition comprising such a combination; a commercial package comprising such a combination as a combined preparation; and to a method of treatment of a warm-blooded animal, especially a human.

公开(公告)号：EP1794149A2

公开(公告)日：2007-06-13

申请号：EP05850758.3

申请日：2005-09-14

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： BOLD, Guido ,  CAPRARO, Hans-georg ,  CARAVATTI, Giorgio ,  FLOERSHEIMER, Andreas ,  FURET, Pascal ,  MANLEY, Paul, W. ,  VAUPEL, Andrea ,  PISSOT SOLDERMANN, Carole ,  GESSIER, François ,  SCHNELL, Christian ,  LITTLEWOOD-EVANS, Amanda, Jane ,  KAPA, Prasad Koteswara ,  BAJWA, Joginder, S. ,  JIANG, Xinglong

IPC分类号： C07D403/12 ,  C07D413/12 ,  C07D239/46 ,  A61K31/505

CPC分类号： C07D239/47 ,  C07D403/12 ,  C07D413/12

摘要： The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.

公开(公告)号：EP1708710A1

公开(公告)日：2006-10-11

申请号：EP05706961.9

申请日：2005-01-21

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BOLD, Guido ,  FLOERSHEIMER, Andreas ,  FURET, Pascal ,  IMBACH, Patricia ,  MASUYA, Keiichi ,  SCHOEPFER, Joseph ,  MARTINY-BARON, Georg

IPC分类号： A61K31/505

CPC分类号： C07D487/04 ,  A61K31/505

摘要： The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.

公开(公告)号：EP1689376A2

公开(公告)日：2006-08-16

申请号：EP04798101.4

申请日：2004-11-26

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BOLD, Guido ,  CARAVATTI, Giorgio ,  FLOERSHEIMER, Andreas ,  GUAGNANO, Vito ,  IMBACH, Patricia ,  MASUYA, Keiichi ,  ROESEL, Johannes ,  VAUPEL, Andrea ,  GARCIA-ECHEVERRIA, Carlos

IPC分类号： A61K31/00

CPC分类号： C04B35/632 ,  C07D239/34 ,  C07D239/47 ,  C07D401/12 ,  C07D403/12

摘要： The invention relates to the use of diaryl urea derivatives for the manufacture of pharmaceutical compositions for the treatment of RET dependent disorders, especially RET dependent tumor diseases. The invention further relates to novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and their use in the treatment of the animal or human body, especially in the treatment of a protein kinase dependent disease, to pharmaceutical compositions comprising such novel N-[4-pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and to the use of such novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as tumour diseases.

公开(公告)号：EP1572686A1

公开(公告)日：2005-09-14

申请号：EP03785795.0

申请日：2003-12-11

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BOLD, Guido ,  FURET, Pascal ,  MANLEY, Paul, William

IPC分类号： C07D409/04 ,  C07D213/64 ,  C07D405/04 ,  C07D417/04 ,  C07D213/74 ,  C07D401/12 ,  C07D213/61 ,  C07D213/38 ,  C07D213/50 ,  A61K31/443 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4412 ,  A61K31/44 ,  A61P35/00

CPC分类号： C07D405/04 ,  C07D213/38 ,  C07D213/50 ,  C07D213/61 ,  C07D213/64 ,  C07D213/74 ,  C07D401/12 ,  C07D409/04 ,  C07D417/04

摘要： The present invention relates to new anthranilic acid amide derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds.

公开(公告)号：EP0929553B1

公开(公告)日：2005-03-16

申请号：EP97911163.0

申请日：1997-09-30

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BOLD, Guido ,  FREI, Jörg ,  LANG, Marc ,  TRAXLER, Peter

IPC分类号： C07D487/04 ,  A61K31/505

CPC分类号： C07D487/04

公开(公告)号：EP1390371A1

公开(公告)日：2004-02-25

申请号：EP02740590.1

申请日：2002-05-13

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BOLD, Guido ,  MANLEY, Paul, William ,  MARTIN-KOHLER, Andreas ,  SEQUIN, Urs

IPC分类号： C07D498/04 ,  C07D493/04 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D491/04

摘要： The invention relates to pharmaceutically acceptable compounds of formula I, wherein the radicals have the significances given in the description. Compounds of formula I are useful against tumor diseases.

公开(公告)号：EP1140944B1

公开(公告)日：2003-08-27

申请号：EP99969216.3

申请日：1999-12-20

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ALTMANN, Karl-Heinz ,  BOLD, Guido ,  CARAVATTI, Giorgio ,  FLÖRSHEIMER, Andreas

IPC分类号： C07D493/04 ,  C07D491/04 ,  C07D413/04 ,  C07D417/04 ,  C07D405/04 ,  C07D401/04 ,  C07D403/04 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4709 ,  A61P35/00

CPC分类号： C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D493/04

公开(公告)号：EP0915841B1

公开(公告)日：2002-02-27

申请号：EP97934472.8

申请日：1997-07-16

申请人： Novartis AG

发明人： FÄSSLER, Alexander ,  BOLD, Guido ,  CAPRARO, Hans-Georg ,  LANG, Marc

IPC分类号： C07C271/22 ,  C07D249/08 ,  C07D295/135

CPC分类号： C07D295/135 ,  C07C271/22 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： The invention relates to compounds of formula (I), in which R1 and R2 are, independently of each other, lower alkyl or lower alkoxy-lower alkyl; R3 and R4 are, independently of each other, sec-lower alkyl or tert-lower alkyl; R5 is phenyl or cyclohexyl; and R6 and R7 are, independently of each other, lower alkyl, or, together with the linking nitrogen atom, pyrrolidino, piperidino, 4-lower alkylpiperidino, 1,2,4-triazol-1-yl or 1,2,4-triazol-4-yl; or a salt thereof, provided that at least one salt-forming group is present. These compounds are inhibitors of HIV protease and are therefore suitable, for example, for treating AIDS or its preliminary stages.

摘要翻译： 本发明涉及式（I）的化合物，其中R 1和R 2彼此独立地为低级烷基或低级烷氧基 - 低级烷基; R3和R4彼此独立地是仲 - 低级烷基或叔 - 低级烷基; R5是苯基或环己基; 并且R6和R7彼此独立地为低级烷基或与连接氮原子一起为吡咯烷基，哌啶子基，4-低级烷基哌啶子基，1,2,4-三唑-1-基或1,2,4-三唑基， 三唑-4-基; 条件是存在至少一个成盐基团。 这些化合物是HIV蛋白酶的抑制剂，因此适用于例如治疗艾滋病或其初期阶段。

公开(公告)号：EP1129074A2

公开(公告)日：2001-09-05

申请号：EP99953967.9

申请日：1999-11-09

申请人： SCHERING AKTIENGESELLSCHAFT ,  Novartis AG

发明人： HUTH, Andreas ,  SEIDELMANN, Dieter ,  THIERAUCH, Karl-Heinz ,  BOLD, Guido ,  MANLEY, Paul, William ,  FURET, Pascal ,  WOOD, Jeanette, Marjorie ,  MESTAN, Jürgen ,  BRÜGGEN, Jose ,  FERRARI, Stefano ,  KRÜGER, Martin ,  OTTOW, Eckhard ,  MENRAD, Andreas ,  SCHIRNER, Michael

IPC分类号： C07D213/38

CPC分类号： C07C237/32

摘要： The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products in the production of anthranilic acid amides.