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    CYCLIC DIARLY UREAS SUITABLE AS TYROSINE KINASE INHIBITORS
    2.
    发明公开
    CYCLIC DIARLY UREAS SUITABLE AS TYROSINE KINASE INHIBITORS 审中-公开
    作为酪氨酸激酶抑制剂的合适的环脲

    公开(公告)号：EP1807412A1

    公开(公告)日：2007-07-18

    申请号：EP05796941.2

    申请日：2005-09-27

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： BOLD, Guido ,  CARAVATTI, Giorgio ,  FLOERSHEIMER, Andreas ,  FURET, Pascal ,  MANLEY, Paul, W. ,  PISSOT SOLDERMANN, Carole ,  VAUPEL, Andrea

    IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/505 ,  A61K31/506 ,  A61P35/00 ,  C07D407/12 ,  C07D417/12 ,  C07D413/12 ,  C07D409/12

    CPC分类号： C07D417/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14

    摘要： The invention relates to novel compounds of Formula (I): wherein p is 1, 2 or 3; n is 0, 1, 2 or 3; mis0,1,2or3; A is CRc, S, NRc or O, where Rc is H or lower alkyl; X, Y and Z are each independently selected fro N or C-R3, wherein at least two of X, Y and Z are N; and each Ra is independently selected from hydrogen and lower-alkyl; each Rb is hydrogen or lower-alkyl; G is a group Ar or represents CN or unsubstituted or substituted lower alkyl; Ar is a saturated or unsaturated cyclic group, which is substituted or unsubstituted and maybe a five or six membered monocyclic or a 8, 9, 10, 11 or 12 membered bicyclic or tricyclic ring and may contain 0, 1, 2 or 3 heteroatoms selected from O, N and S; and wherein the radicals have R1, R2, R3 and R4 have the meanings as defined herein, to salts, esters, N-oxides or prodrugs thereof; and their use in the treatment of protein kinase dependent diseases, their use in the manufacture of pharmaceutical compositions for use in the treatment of said diseases, methods of use of diaryl urea derivatives in the treatment of said diseases, pharmaceutical preparations comprising these novel diaryl urea derivatives, processes for the manufacture of the novel diaryl urea derivatives, the use or methods of use of the novel diaryl urea derivatives as mentioned above, and/or these novel diaryl urea derivatives for use in the treatment of the animal or human body.