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公开(公告)号：EP0759912A1
公开(公告)日：1997-03-05
申请号：EP95915677.0
申请日：1995-04-13
CPC分类号： C07D271/07
摘要： This invention relates to novel 2-[4-(5-substituted-1,2,4-oxadiazol-3-ylmethoxy)benzyl]-1,2,5-oxadiazolidine-3,5-diones which have demonstrated antihyperglycemic activity in diabetic (ob/ob and db/db) mice, genetic animal models of non-insulin dependent diabetes mellitus (NDDM or Type II diabetes). These compounds are represented by Formula (I), wherein R1 is C6-C10 aryl, optionally substituted by one to three substituents independently selected from C1-C6 alkyl, C1-C6 alkoxy, fluorine, chlorine, bromine, iodine, C1-C3 trifluoroalkyl or C1-C3 trifluoroalkoxy; and R2 is selected from the group consisting of hydrogen, C¿1?-C6 alkyl, fluorine, chlorine, bromine, iodine, C1-C6 alkoxy, C1-C3 trifluoroalkyl, and C1-C3 trifluoroalkoxy, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP0759780A1
公开(公告)日：1997-03-05
申请号：EP95918442.0
申请日：1995-05-08
发明人： CHU, Hsien-Jue
CPC分类号： A61K39/39 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , A61K2039/70 , C12N2710/16734 , C12N2760/18534 , C12N2760/18634 , C12N2770/24334 , A61K2300/00
摘要： The invention provides an improved BRSV vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises a modified live BRS virus and an adjuvant, which in combination provide immunity from BRSV infection after a single administration, and elicit an immune response specific to BRSV and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the BRS virus is strain 375, and the adjuvant comprises an unsaturated turpin hydrocarbon, preferably squalene or squalane, and a polyoxypropylene-polyoxyethylene block copolymer, most preferably one where the copolymer has a polyoxypropylene (POP) component with an average molecular weight of about 3250 to 4000 and the polyoxyethylene (POE) component comprises about 10-20 % of the total molecule. The adjuvant may optionally include a surfactant, preferably a polyoxyethylenesorbitan monooleate.
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63.发明授权
公开(公告)号：EP0511865B1
公开(公告)日：1997-01-29
申请号：EP92303917.6
申请日：1992-04-30
IPC分类号： C07D231/08 , A61K31/415 , C07D231/22 , C07D231/26 , C07D401/04 , C07D401/06 , C07D401/12
CPC分类号： C07D401/04 , C07D231/08 , C07D231/22 , C07D231/26 , C07D401/06 , C07D401/12
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公开(公告)号：EP0499399B1
公开(公告)日：1997-01-15
申请号：EP92300987.2
申请日：1992-02-06
CPC分类号： A61K9/0014 , A61K31/19 , Y10S514/871 , Y10S514/887 , Y10S514/939 , Y10S514/969
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65.发明公开
公开(公告)号：EP0749430A1
公开(公告)日：1996-12-27
申请号：EP95911696.0
申请日：1995-02-08
CPC分类号： C07D417/12 , C07D277/36 , C07D277/74
摘要： This invention relates to novel 5-[3-aryl-prop-2-ynyl]-5-(arylsulfonyl)-thiazolidine-2,4-diones and 5-[3-aryl-prop-2-ynyl]-5-(arylsulfanyl)thiazolidine-2,4-diones characterized by general formula (I), wherein Ar is phenyl, 2-naphthyl, alkyl substituted phenyl, alkoxy substituted phenyl, halogen substituted phenyl, 2-pyridinyl, substituted 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 2-quinolinyl, 2-pyrimidinyl, 2-benzoxazolyl, 2-benzthiazolyl, 2-benzimidazolyl, 2-furanyl, 2-benzo-[b]-furanyl, 2-thienyl, 2-benzo-[b]-thienyl; n is 0 or 2; and Ar' is phenyl, alkyl substituted phenyl, perfluoroalkyl substituted phenyl, halogen substituted phenyl, alkoxy substituted phenyl, perfluoroalkoxy substituted phenyl and alkylthio substituted phenyl. This invention also relates to the use of the abovementioned compounds in lowering the blood glucose levels in hyperglycemic mammals and pharmaceutical compositions containing the same.
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公开(公告)号：EP0655065B1
公开(公告)日：1996-12-11
申请号：EP93919994.9
申请日：1993-08-12
IPC分类号： C07D498/18 , C07F7/18 , A61K31/435
CPC分类号： C07D498/18
摘要： This invention provides a compound of formula (I), and 27-substituted derivatives thereof which are useful as immunosuppressive, anti-inflammatory, antifungal, antitumor, and antiproliferative agents. The compound depicted by formula (I) is named 27-hydroxyrapamycin, and may also be referred to as 27-deoxo-27-hydroxyrapamycin.
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67.发明公开Mammalian vaccines composition comprising squalene or squalane, phospholipid and a surfactant as adjuvant 失效的哺乳动物疫苗组合物，包含角鲨烯或角鲨烷，磷脂和表面活性剂作为佐剂
公开(公告)号：EP0745388A1
公开(公告)日：1996-12-04
申请号：EP96303930.0
申请日：1996-05-31
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/55566 , Y02A50/466 , Y02A50/484
摘要： The present invention discloses mammalian vaccine compositions having an effective amount of an adjuvant, the adjuvant comprising squalene or squlane, one or more phospholipids and a surfactant. These compositions also optionally contain an aluminium salt and one or more pharmaceutically acceptable buffers.
摘要翻译： 在具有有效量的佐剂本发明盘松动哺乳动物疫苗组合物，佐剂的角鲨烯，其包含或squlane，一种或多种磷脂和表面活性剂。 这些组合物，以便任选地含有铝的盐和一种或多种药学上可接受的缓冲剂。
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68.发明授权N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase 失效N，N'，N'-三取代-5'-双氨基亚甲基-1,3-二恶烷-4,6-二酮α酰-CoA：胆固醇 - 酰基转移酶
公开(公告)号：EP0471493B1
公开(公告)日：1996-05-22
申请号：EP91307196.5
申请日：1991-08-06
IPC分类号： C07D319/06 , A61K31/335 , C07D405/12 , C07F7/18 , A61K31/445 , A61K31/695
CPC分类号： C07D405/12 , C07D319/06 , C07F7/1852
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69.发明公开N-(PIPERIDINYL-1-ALKYL)-SUBSTITUTED CYCLOHEXANE CARBOXYLIC ACID AMIDES AS 5-HT1A RECEPTOR ANTAGONISTS 失效N-（哌啶基-1-烷基） - 取代的CYCLOHEXANCARBONSÄUREAMIDEAS 5HT1A受体拮抗剂
公开(公告)号：EP0711291A1
公开(公告)日：1996-05-15
申请号：EP94920550.0
申请日：1994-07-12
发明人： CLIFFE, Ian Anthony, Wyeth Laboratories , ASHWELL, Mark Antony, Wyeth Laboratories , WARD, Terence James, Wyeth Laboratories , WHITE, Alan Chapman, Wyeth Laboratories , BAUDY, Reinhardt Bernhard
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： Compounds of formula (I) and the pharmaceutically acceptable acid addition salts thereof are 5-HT1Abinding agents and may be used, for example, as anxiolytics. In the formula a and b each represents 0, 1, 2 or 3 such that the sum of a + b is 0, 1, 2 or 3, the dotted line represents an optional double bond which may be present in the ring, provided that a is at least 1, A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, R is a mono or bicyclic aryl or heteroaryl radical with the proviso that R is not an unsubstituted phenyl group, R1 is a mono or bicyclic heteroaryl radical, and R2 is cycloalkyl or cycloalkenyl.
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公开(公告)号：EP0376744B1
公开(公告)日：1995-08-16
申请号：EP89313684.6
申请日：1989-12-29
IPC分类号： C12N15/50 , C07K14/165 , C12P21/08 , G01N33/569
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C07K16/10 , C12N2710/24143 , C12N2770/20022
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