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61.发明公开SPACER, FASTENING ASSEMBLY HAVING SAID SPACER, AND PROCESS OF RELEASING SAID FASTENING ASSEMBLY 审中-公开间隔区，与分隔件安装的安排，法求解BEFESTIGUNSANORDNUNG
公开(公告)号：EP1629210A1
公开(公告)日：2006-03-01
申请号：EP04734942.8
申请日：2004-05-26
申请人： Union Seimitsu Co., Ltd. , Nec Tokin Corporation , SHARP KABUSHIKI KAISHA , TOKAI UNIVERSITY EDUCATIONAL SYSTEM
发明人： SUGIYAMA, Kazuo, c/o UNION SEIMITSU CO., LTD. , TASHIMA, Tadashi, c/o UNION SEIMITSU CO., LTD. , YOSHIDA, Kazunari, c/o Tokai Univ. Educ. System , KAGAMI, Yu, c/o NEC TOKIN Corporation , TAKAARA, Hideo, c/o NEC TOKIN Corporation , SHINDOH, Yoshio, c/o SHARP KABUSHIKI KAISHA , TANIGAWA, Masanobu, c/o SHARP KABUSHIKI KAISHA
CPC分类号： F16B21/18 , F16B5/02 , F16B43/004 , Y10T29/49821 , Y10T403/75
摘要： A spacer (10, 10' , 10') disposed around a fastening piece (17) secured to a main fastening body (25a) , the spacer sandwiched between ahead (17b) of the fastening piece and a securing object (22) so that the spacer bears a securing force of the fastening piece to press the securing object. spacer includes a pair of arms (12, 13) made of a shape restoring material. Each arm has a fore end, and the fore ends are joined to each other with an adhesive material that is softened when heated. The arms expands radially such that the screw attachment is released from the head of the fastening piece when heat or force is applied to the arms.
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公开(公告)号：EP0980695A2
公开(公告)日：2000-02-23
申请号：EP99116292.6
申请日：1999-08-18
发明人： Matsumae, Mitsunori, Dept. of Neurosurgery Tokai U , Kaneda, Michihiro, c/o Nippon Infrared Industries
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B90/10 , A61B2017/00084 , A61B2018/2211
摘要： A device for heating a biotissue employing strong light, characterized in that, in thermotherapy comprising leading a biotissue to necrosis by heating the biotissue by strong light from a light source, in order to lead a predetermined biotissue to necrosis at a temperature region before reaching tissue transpiration during raising the temperature of said biotissue, temperature measurement is performed by a temperature meter measuring the spatial temperature distribution of the biotissue at a real time, and that the light output of the light source, the on-time of intermittent irradiation and the off-time of intermittent irradiation are controlled on the basis of the information at a real time to accomplish remedial conditions.
摘要翻译： 一种用于利用强光加热生物组织的装置，其特征在于，在热疗中包括通过来自光源的强光加热生物组织以导致生物组织坏死，以便在到达组织之前的温度区域导致预定的生物组织坏死 在升高所述生物组织的温度期间的蒸发，温度测量由实时测量生物组织的空间温度分布的温度计执行，并且光源的光输出，间歇照射的开启时间和关闭 根据该信息实时控制间歇照射的时间以实现补救条件。
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公开(公告)号：EP4382107A1
公开(公告)日：2024-06-12
申请号：EP22853118.2
申请日：2022-08-03
IPC分类号： A61K31/57 , A61K9/127 , A61K39/395 , A61P35/00 , A61P43/00
CPC分类号： A61P43/00 , A61K39/395 , A61P35/00 , A61K9/127 , A61K31/57
摘要： The present invention provides a novel activity regulator capable of regulating T cell and/or B cell activity. The activity regulator is a T cell and/or B cell activity regulator comprising progesterone or a derivative thereof as an active ingredient.
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公开(公告)号：EP2902483B1
公开(公告)日：2020-03-11
申请号：EP13842351.2
申请日：2013-09-30
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公开(公告)号：EP3568153A1
公开(公告)日：2019-11-20
申请号：EP18738758.4
申请日：2018-01-12
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66.发明授权
公开(公告)号：EP1108434B1
公开(公告)日：2014-05-14
申请号：EP99938581.8
申请日：1999-08-23
发明人： MIYATA, Toshio
IPC分类号： A61K45/00 , A61K31/155 , A61K31/15 , A61K33/44 , A61K31/44 , A61K31/195 , A61K38/38 , A61M1/28
CPC分类号： A61K31/203 , A61K31/155 , A61K31/4965 , A61K33/00 , A61M1/287 , Y10S514/832 , Y10S514/866 , A61K2300/00
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公开(公告)号：EP2662453A2
公开(公告)日：2013-11-13
申请号：EP13003496.0
申请日：2008-07-31
申请人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM , Tokyo Metropolitan Institute of Medical Science , Renascience CO., LTD. , Medical and Biological Laboratories Co., Ltd.
发明人： Itokawa, Masanari , Miyata, Toshio , Arai, Makoto
IPC分类号： C12Q1/68 , A61K31/415 , A61K31/4152 , A61K31/437 , A61K31/4415 , A61K31/4439 , A61K45/00 , A61P25/18 , C12N15/09 , G01N30/88 , G01N33/15
CPC分类号： C12Q1/527 , A61K31/415 , A61K31/4152 , A61K31/437 , A61K31/4415 , A61K31/4439 , C12Q1/686 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2333/988
摘要： The present invention relates to a method for diagnosing schizophrenia comprising measuring at least one parameter in a subject, the parameter being selected from the group consisting of (1) a genetic abnormality of glyoxalase I gene, (2) the expression level or activity of glyoxalase I in a biological sample, (3) the amount of a carbonyl-modified protein that is a protein modified with the carbonyl-compound, preferably pentosidine, in a biological sample, and (4) the amount of pyridoxal in a biological sample. The present further relates to a primer, a probe and a reagent for use in said method, as well as an AGE-reader and its use for measuring the amount of carbonyl-modified proteins.
摘要翻译： 本发明涉及一种诊断精神分裂症的方法，包括测量受试者中的至少一个参数，所述参数选自（1）乙二醛酶I基因的遗传异常，（2）乙醛酸酶的表达水平或活性 I在生物样品中，（3）在生物样品中用羰基化合物（优选戊糖）修饰的蛋白质的羰基修饰蛋白质的量，和（4）生物样品中吡哆醛的量。 本发明还涉及用于所述方法的底漆，探针和试剂，以及AGE读数器及其用于测量羰基修饰的蛋白质的量的用途。
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68.发明公开INTERVERTEBRAL DISC NUCLEUS PULPOSUS STEM/PROGENITOR CELL, METHOD FOR CULTURING SAME, AND APPLICATION 审中-公开BAND DISCS-髓核家长/及其使用PRE细胞培养和方法
公开(公告)号：EP2554660A1
公开(公告)日：2013-02-06
申请号：EP11762825.5
申请日：2011-03-29
IPC分类号： C12N5/077 , A61K35/28 , A61K38/00 , A61P19/00 , C12N5/0775
CPC分类号： C12N5/0654 , A61K35/12 , C12N5/0655 , C12N5/0668 , C12N2501/17 , C12N2502/1394 , C12N2502/99
摘要： The purpose of the present invention is to provide intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. The present invention provides an intervertebral disk nucleus pulposus cell characterized by being isolated from the intervertebral disk nucleus pulposus of a vertebrate and being positive for at least one surface marker from among Tie2 and GD2. That is, the present invention provides an intervertebral disk nucleus pulposus stem cell characterized by being at least Tie2-positive for the surface marker and possessing self-renewal ability as well as multipotency capable of differentiating into adipocytes, osteocytes, chondrocytes and neurons. The present invention also provides an intervertebral disk nucleus pulposus progenitor cell characterized by being at least Tie2-negative and GD2-positive for the surface marker and capable of differentiating into any of adipocytes, osteocytes, chondrocytes and neurons.
摘要翻译： 本发明的目的是提供一种椎间盘髓核干细胞或祖细胞也可以用于治疗椎间盘病症。 本发明提供了由来自脊椎动物的椎间盘髓核中分离并从Tie2的和GD2中用于至少一个表面标记是正的特征的椎间盘髓核细胞。 即，本发明提供了对通过至少是Tie2的正面为表面标志物和特点波塞唱能够分化成脂肪细胞，骨细胞，软骨细胞和神经细胞的自我更新能力，以及多能椎间盘髓核干细胞。 本发明因此提供了关于通过至少是特征的椎间盘髓核祖细胞Tie2的负和GD2阳性的表面标记物和能分化成任何的脂肪细胞，骨细胞，软骨细胞和神经元。
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69.发明公开
公开(公告)号：EP2446928A1
公开(公告)日：2012-05-02
申请号：EP10815423.8
申请日：2010-09-09
发明人： ITOH, Johbu
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B18/18 , A61B2018/1807 , A61N5/0613 , A61N2005/0654 , A61N2005/0661
摘要： It is an object of the present invention to provide a method and an apparatus capable of selectively damaging and killing tumor cells. In one aspect of the present invention, there is provided a method for selectively damaging and killing tumor cells comprising a step of irradiating tumor cells with a pulse light having continuous emission spectra ranging at least from 230 to 270 nm (UV pulse flash), outside a living body of a human or a living body of a non-human animal or in a living body of a non-human animal. The UV pulse flash, preferably, has an accumulated irradiation amount per unit area that is achieved at a distance of 8 cm from a light source having an integrated output of, for example, 90, 180-7100 or 14200 J. In other words, the UV pulse flash, preferably, has an accumulated irradiation amount per unit area of, for example, 6, 12-480 or 960 J/cm 2 in terms of an energy originated from a wavelength of UVC. The step of irradiating with the UV pulse flash is preferably carried out, for example, within 1 minute. The UV pulse flash is preferably emitted from a xenon flash lamp. As another aspect of the present invention, there is provided an apparatus for treating tumor tissues comprising a light source of the UV pulse flash.
摘要翻译： 它是本发明的一个目的是提供一种方法和一种能够选择性地破坏和杀死肿瘤细胞的装置。 在本发明的一个方面，提供了一种方法，用于选择性破坏和杀死肿瘤细胞，其包括照射肿瘤细胞与具有连续发射光谱范围的至少230至270纳米（UV脉冲闪光）的脉冲光的步骤中，外 人类的活体或非人类动物的或在非人类动物的生物体内的生物体。 的UV脉冲闪光灯，优选地，具有对没有由具有在积分输出，例如，90，180-7100或14200 J.换句话说光源取得在8厘米的距离每单位面积的累积照射量， 紫外脉冲闪光灯，优选地，具有每单位面积累积照射量，例如，6，12至480或960焦耳/ cm 2的在能量方面源于UVC的波长。 用UV脉冲闪光照射的步骤优选进行，例如，分钟内的第一 的UV脉冲闪光灯优选由氙闪光灯发射的。 作为本发明的另一个方面，提供了到用于治疗肿瘤组织，包括紫外脉冲闪光的光源。
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70.发明授权
公开(公告)号：EP2058353B1
公开(公告)日：2012-02-15
申请号：EP07806534.9
申请日：2007-08-31
CPC分类号： C08G73/1046 , C07F9/091 , C08G18/10 , C08G18/3206 , C08G69/26 , C08G73/105 , C08G18/4854 , C08G18/3889
摘要： Disclosed is a highly polymerizable diamine compound containing a phosphorylcholine group. Also disclosed is a high molecular weight polymer which uses the phosphorylcholine group-containing highly polymerizable diamine compound as one of the starting raw materials and is improved in mechanical strength, water resistance and heat resistance, while maintaining excellent biocompatibility and workability as an MPC polymer. Further disclosed is a method for producing such a high molecular weight polymer. Specifically disclosed is a specific diamine compound represented by the formula (I) below and containing a phosphorylcholine group. Also specifically disclosed is a polymer represented by the formula (II) below and having a number average molecular weight of not less than 5,000, while containing at least 1% by mole of a specific structural unit having a phosphorylcholine group. Further specifically disclosed is a method for producing such a polymer by using the diamine compound as one of the raw materials.
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