公开(公告)号：EP2627425A4

公开(公告)日：2014-11-05

申请号：EP11833232

申请日：2011-10-11

Applicant: ABBVIE INC

Inventor： WANG CHEN ,  HICKMAN ROBERT K

IPC: B01D15/08

CPC classification number: C07K1/36 ,  B01D15/125 ,  B01D15/1871 ,  B01D15/305 ,  B01D15/327 ,  B01D15/361 ,  B01D15/3809 ,  B01D15/3828 ,  B01D15/3847 ,  C12M47/12

公开(公告)号：EP2745903A1

公开(公告)日：2014-06-25

申请号：EP13198648.1

申请日：2013-12-19

Applicant: Dionex Corporation

Inventor： LIU, Xiaodong ,  AICH, Udayanath ,  POHL, Christopher A.

IPC: B01D15/38 ,  C07K1/16 ,  G01N33/68

CPC classification number: C08B37/0063 ,  B01D15/3847 ,  B01J20/286 ,  B01J20/3285 ,  B01J41/20 ,  B01J43/00 ,  B01J2220/54 ,  C07K1/165 ,  G01N30/482 ,  B01D15/363 ,  B01D15/305 ,  B01D15/325 ,  B01D15/362

Abstract: An exemplary multimodal chromatographic medium of the invention includes one or more strong anion exchange, weak anion exchange, strong cation exchange and/or weak cation exchange binding sites in combination with one or more reverse phase and/or hydrophilic interaction chromatography binding site. In an exemplary embodiment, the sites interact with one or more glycans in a mixture of glycans in a manner that allows separation of glycans in the mixture and analysis of the glycan mixture. The media are incorporated into devices and systems for chromatographic analysis. Also provided are methods of using the multimodal media of the invention to analyze glycans.

Abstract translation: 本发明的示例性多峰色谱介质包含与一个或多个反相和/或亲水相互作用色谱结合位点结合的一个或多个强阴离子交换，弱阴离子交换，强阳离子交换和/或弱阳离子交换结合位点。 在一个示例性实施方案中，所述位点以聚糖混合物中的一种或多种聚糖与允许混合物中的聚糖分离和聚糖混合物分析的方式相互作用。 将介质并入用于色谱分析的装置和系统中。 还提供了使用本发明的多峰介质来分析聚糖的方法。

公开(公告)号：EP2673065A1

公开(公告)日：2013-12-18

申请号：EP12704758.7

申请日：2012-02-10

Applicant: Leiden University Medical Center ,  F. Hoffmann-La Roche AG

Inventor： WUHRER, Manfred ,  HEMAYATKAR, Mahdi ,  SELMAN, Maurice Henricus Johannes

IPC: B01D15/32 ,  C07K1/20 ,  G01N33/68

CPC classification number: G01N33/6851 ,  B01D15/26 ,  B01D15/305 ,  C07H1/06 ,  C07K1/20 ,  C07K1/22 ,  G01N33/6848 ,  Y10T436/143333

Abstract: A method of purifying a glycan and/or a glycoconjugate comprising the steps of: (a) providing a stationary phase that comprises cotton; (b) applying a glycan and/or glycoconjugate-containing sample to the stationary phase; (c) washing the stationary phase with a first solvent; and (d) eluting the glycan and/or glycoconjugate from the stationary phase with a second solvent. A kit for purifying a glycan and/or glycoconjugate, the kit comprising: a stationary phase comprising cotton; and instructions for purifying a glycan and/or glycoconjugate according to the disclosed method.

公开(公告)号：EP2271416A4

公开(公告)日：2012-07-04

申请号：EP09733746

申请日：2009-04-27

Applicant: BIOCIUS LIFE SCIENCES INC

Inventor： OZBAL CAN

IPC: B01D15/32 ,  B01D15/22 ,  B01D15/30 ,  G01N30/60

CPC classification number: B01J20/26 ,  B01D15/22 ,  B01D15/305 ,  B01D15/327 ,  B01J20/267 ,  B01J20/28011 ,  B01J20/28052 ,  B01J20/287 ,  B01J2220/52 ,  G01N30/6039 ,  G01N30/6069 ,  G01N30/6082 ,  G01N30/6091 ,  G01N30/7233

公开(公告)号：EP1387390A3

公开(公告)日：2004-04-07

申请号：EP03025393.4

申请日：1998-06-19

Applicant: Ciphergen Biosystems, Inc.

Inventor： Hutchens, William T. ,  Yip, Tai-Tung

IPC: H01J49/04

CPC classification number: C40B30/04 ,  B01D15/305 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3265 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3285 ,  B01J20/3289 ,  G01N30/00 ,  G01N30/02 ,  G01N30/461 ,  G01N30/466 ,  G01N33/538 ,  G01N33/54353 ,  G01N33/6803 ,  G01N33/6845 ,  B01D15/327 ,  B01D15/363 ,  B01D15/3804 ,  B01D15/322 ,  B01D15/362 ,  B01D15/38 ,  B01D15/26

Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectively conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.

Abstract translation: 本发明提供了用于分离样品中分析物的滞留层析方法。 该方法包括在多种不同的选择性条件下将分析物吸附到基质上，并通过解吸光谱法检测保留在基质上的分析物。 这些方法在生物学和医学中很有用，包括临床诊断和药物发现。

公开(公告)号：EP0783366A1

公开(公告)日：1997-07-16

申请号：EP95933659.0

申请日：1995-09-20

Applicant: MASSEY UNIVERSITY

Inventor： BURTON, Simon, C. ,  HAGGARTY, Neill, Ward ,  HARDING, David, R., K. ,  BECKER, Nathaniel, Todd ,  BULTHUIS, Ben, A. ,  STEELE, Landon, M.

IPC: B01J20 ,  B01D15 ,  B01J39 ,  C07K1 ,  C08F8 ,  C08F220 ,  C12N9 ,  G01N30

CPC classification number: B01J20/3242 ,  B01D15/305 ,  B01D15/327 ,  B01D15/36 ,  B01D15/3847 ,  B01J20/289 ,  B01J20/3219 ,  B01J20/3246 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3285 ,  B01J39/26 ,  B01J2220/54 ,  C07K1/00 ,  C07K1/165 ,  C12N9/54 ,  C12N9/6481 ,  C12N9/6483 ,  C12Y304/23004

Abstract: Disclosed are rationally designed mixed mode resins which are useful in recovering a target compound from an aqueous solution and methods for use of such resins. The resins described herein have a hydrophobic character at the pH of binding of the target compound and a hydrophilic and/or electrostatic character at the pH of desorption of the target compound from the resin and are specifically designed to bind the target compound from an aqueous solution at both a low and high ionic strength.