公开(公告)号：EP0622394A1

公开(公告)日：1994-11-02

申请号：EP93870076.2

申请日：1993-04-30

申请人： S.A. LABORATOIRES S.M.B.

发明人： Looze, Yvan, U.L.B., Faculty of Medecine ,  Vincentelli, Jean, U.L.B., Faculty of Medecine ,  Brygier, Jeanne, U.L.B., Faculty of Medecine ,  Paul, Claudine, U.L.B., Faculty of Medecine ,  Nijs, Michelle, U.L.B., Faculty of Medecine ,  Guermant, Claude, U.L.B., Faculty of Medecine ,  Volant-Baeyens, Danièle ,  Deboeck, Arthur ,  Baudier, Philippe

IPC分类号： C08G65/32 ,  A61K47/48 ,  C07K3/08

CPC分类号： C08G65/338 ,  A61K47/60 ,  C07K1/1077 ,  C08G65/334

摘要： Poly(alkylene glycol) derivatives of the formula :



        PAG [ O - V - Hg ⊖ x ⊕ ] n



or



        PAG [ O - V₁ - S - R₁ ] n



wherein

PAG is a poly(alkylene glycol),
x is a counter ion,
V, V₁ is a non polymeric organic group,
n is 1 or 2, and
R₁ is selected from the group of -SO₃ ⊕ ; -S-SO₃ ⊕ ; -SO₂CH₃; thiopyridyl; nitrosulfenyl; otherwise substituted sulfenyl; -SO-(CH₂) m -CH₃ with m = 0, 1, ...; -SO m -CH₂-CH=CH₂ with m = 1, 2; -SO₂-R where R is alkyl or aryl.

摘要翻译： 聚式（亚烷基二醇）衍生物：PAG〔O - V - 汞<（ - ）> X <（+）>] n或PAG〔O - V1 - S - R1] n的worin PAG是聚（亚烷基二醇 ）中，x是抗衡离子，V，V1是一种非聚合的有机基团，n是1或2，且R 1选自下组：-SO 3中选择<（+）>; -S-SO 3 <（+）>; 2 CH 3; 硫代吡啶; nitrosulfenyl; 其它形式取代硫基; -SO-（CH 2）M-CH 3，其中m = 0，1，...; -SOm-CH2-CH = CH 2，其中m = 1，2; -SO 2 R，其中R是烷基或芳基。

公开(公告)号：EP0259172B1

公开(公告)日：1992-09-16

申请号：EP87307814.1

申请日：1987-09-04

申请人： COURTAULDS COATINGS (HOLDINGS) LIMITED

发明人： Andrews, Adrian Ferguson ,  Hugh, Nicolas Saint John ,  Nunn, Michael John

IPC分类号： C09D133/00 ,  C09D171/00 ,  C09D167/00

CPC分类号： C09D171/02 ,  C08G65/2621 ,  C08G65/3312 ,  C08G65/3324 ,  C08G65/334 ,  C09D201/08 ,  C08L2666/02

公开(公告)号：EP0259172A2

公开(公告)日：1988-03-09

申请号：EP87307814.1

申请日：1987-09-04

申请人： COURTAULDS COATINGS (HOLDINGS) LIMITED

发明人： Andrews, Adrian Ferguson ,  Hugh, Nicolas Saint John ,  Nunn, Michael John

IPC分类号： C09D133/00 ,  C09D171/00 ,  C09D167/00

CPC分类号： C09D171/02 ,  C08G65/2621 ,  C08G65/3312 ,  C08G65/3324 ,  C08G65/334 ,  C09D201/08 ,  C08L2666/02

摘要： A coating composition comprises an anhydride polymer (A) containing a least two cyclic carboxylic acid an­hydride functional groups and a polymer (B) containing at least two functional groups reactive with anhydride groups and selected from hydroxyalkylamino, hydroxyalkoxy­alkylamino, hydroxy-substituted acyloxyalkylamino, hydr­oxy-substituted polyacyloxyalkylamino, mercaptoalkylamino and oxazolidino groups. One of the polymers (A) and (B) comprises at least one flexible polymer chain selected from polyether, polyester, silicone, diene polymer, hydro­genated diene polymer, polyurethane, polyisobutylene and polyacrylate chains. The functional groups character­istic of that polymer are each present as a terminal group at the end of a flexible polymer chain.

摘要翻译： 涂料组合物包含含有至少两个环状羧酸酐官能团的酸酐聚合物（A）和含有至少两个与酸酐基反应的官能团的聚合物（B），选自羟基烷基氨基，羟基烷氧基烷基氨基，羟基取代的酰氧基烷基氨基， 取代的聚酰氧基烷基氨基，巯基烷基氨基和恶唑烷基。 聚合物（A）和（B）中的一种包含至少一种选自聚醚，聚酯，硅酮，二烯聚合物，氢化二烯聚合物，聚氨酯，聚异丁烯和聚丙烯酸酯链的柔性聚合物链。 该聚合物的特征性官能团各自以柔性聚合物链末端作为末端基团存在。

公开(公告)号：EP0013000A3

公开(公告)日：1981-01-21

申请号：EP79105279

申请日：1979-12-19

申请人： DYNAPOL

发明人： Parkinson, Thomas M. ,  Brown, Joseph P. ,  Wingard, Jr., Robert E.

IPC分类号： A61K31/745 ,  A61K31/785 ,  A61K31/795 ,  A61K09/18

CPC分类号： C08G85/004 ,  A61K31/785 ,  A61K31/795 ,  A61K47/58 ,  A61K47/59 ,  A61K47/60 ,  C08F8/30 ,  C08F8/34 ,  C08G65/334 ,  C08G65/48 ,  C08F12/02

摘要： An intestinal anti-inflammatory preparation comprising a polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed. The polymeric agent comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate's salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymers' azo bonds undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.

公开(公告)号：EP0013000A2

公开(公告)日：1980-07-09

申请号：EP79105279.8

申请日：1979-12-19

申请人： DYNAPOL

发明人： Parkinson, Thomas M. ,  Brown, Joseph P. ,  Wingard, Jr., Robert E.

IPC分类号： A61K31/745 ,  A61K31/785 ,  A61K31/795 ,  A61K9/18

CPC分类号： C08G85/004 ,  A61K31/785 ,  A61K31/795 ,  A61K47/58 ,  A61K47/59 ,  A61K47/60 ,  C08F8/30 ,  C08F8/34 ,  C08G65/334 ,  C08G65/48 ,  C08F12/02

摘要： An intestinal anti-inflammatory preparation comprising a polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed. The polymeric agent comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate's salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymers' azo bonds undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.

公开(公告)号：EP3395857A1

公开(公告)日：2018-10-31

申请号：EP16878558.2

申请日：2016-12-16

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： NAKAMURA Masaharu ,  FUKUDA Tsuyoshi ,  YAMAKAWA Ken ,  KATO Takuya

IPC分类号： C08G69/48 ,  A61K31/282 ,  A61K31/555 ,  A61K47/50 ,  A61P35/00 ,  C08G65/334 ,  C08G69/08 ,  C08G81/00

CPC分类号： A61K31/282 ,  A61K31/555 ,  C08G65/334 ,  C08G69/08 ,  C08G69/48 ,  C08G81/00

摘要： A DDS preparation of a platinum complex, which exhibits a superior antitumor effect required as a medicine and reduced side effects, that is, a clinically usable DDS preparation of a platinum complex, which is conjugated to a polymer carrier that is different from conventional carriers, is desired.
Provided is a polymer conjugate of a platinum(II) complex, the polymer conjugate including: a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; a sulfoxide derivative introduced into a side-chain carboxyl group of the block copolymer; and a platinum(II) complex coordinate-bonded to a sulfoxide group of the sulfoxide derivative.

公开(公告)号：EP3315531A4

公开(公告)日：2018-06-20

申请号：EP16813656

申请日：2016-06-08

申请人： XIAMEN SINOPEG BIOTECH CO LTD

发明人： WENG WENGUI ,  LIU CHAO ,  YAN CE ,  SU HUIHUANG ,  ZHOU CHUN

IPC分类号： C08G65/334 ,  A61K47/50 ,  C08G65/332 ,  C08G65/333 ,  C08G83/00

CPC分类号： C08G65/334 ,  A61K47/50 ,  C08G65/332 ,  C08G65/333 ,  C08G83/002 ,  C08G2650/32

摘要： Disclosed are an 8-arm polyethylene glycol (PEG) derivative (formula 1), manufacturing method and modified bio-related substance thereby, wherein a tetravalent group U and four trivalent groups E c form a highly symmetric octavalent central structure CORE 0 together, L c connects the octavalent center to eight PEG arms having polydiversity or monodiversity and having n 1 -n 8 as the degrees of polymerization thereof. The terminal of one PEG chain is connected to at least one functional group F (k ‰¥ 1), and said PEG chain and F can be directly connected (g = 0) or connected with a divalent linking group L 0 connected with a terminal branched group G (g = 1) therebetween. The latter provides more reacting sites to combine more pharmaceutical molecules, thereby increasing the drug loading capacity. The near-center symmetric structure of the derivative allows more precise control over the molecular weight during large-scale production, thereby facilitating acquisition of a product having a narrower molecular weight distribution. A bio-related substance modified thereby has a more uniform and controllable performance.

公开(公告)号：EP3318591A1

公开(公告)日：2018-05-09

申请号：EP16817961.2

申请日：2016-06-29

申请人： Tohoku Techno Arch Co., Ltd. ,  NOF Corporation

发明人： KINBARA Kazushi ,  MURAOKA Takahiro ,  WAWRO Adam Marcin ,  OHTAKE Tomoyuki ,  KANG Eui-chul ,  URUGA Tomoki ,  IMAMURA Ryutaro

IPC分类号： C08G65/333 ,  C08G65/334

CPC分类号： C08G65/46 ,  B01D11/0492 ,  B01D15/362 ,  B01D15/363 ,  B01D15/366 ,  C08G65/333 ,  C08G65/334 ,  C08G65/48 ,  C08G2650/50

摘要： Provided is a hetero type monodispersed polyethylene glycol which contains a compound represented by formula (1) ((1): NH 2 -(CH 2 CH 2 O) a -CH 2 CH 2 COOH (in formula (1), a is an integer between 6 and 40)) and in which the following each satisfy a specified relational expression: (A) a chromatogram detected by a differential refractometer when separation is carried out using reversed phase chromatography; (B) a chromatogram detected by a differential refractometer when separation is carried out using cation exchange chromatography; and (C) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol containing a compound represented by formula (1) is derivatized and separation is carried out using anion exchange chromatography.

摘要翻译： 提供含有式（1）（式（1）：NH 2 - （CH 2 CH 2 O）a -CH 2 CH 2 COOH（式（1）中，a为6〜40的整数）所示的化合物的异种单分散聚乙二醇， 其中每个满足指定的关系表达式：（A）当使用反相色谱进行分离时由差示折光计检测的色谱图; （B）当使用阳离子交换色谱进行分离时，由差示折光计检测的色谱图; 和（C）当含有由式（1）表示的化合物的异型单分散聚乙二醇被衍生并且使用阴离子交换色谱进行分离时，由差示折光计检测到的色谱图。

公开(公告)号：EP3283549A1

公开(公告)日：2018-02-21

申请号：EP16720735.6

申请日：2016-04-15

申请人： Freie Universität Berlin

发明人： HAAG, Rainer ,  REIMANN, Sabine ,  DERNEDDE, Jens

IPC分类号： C08G65/334 ,  C08G65/48 ,  C08G65/22 ,  C08G83/00

CPC分类号： A61K47/60 ,  A61K47/10 ,  C08G65/22 ,  C08G65/334 ,  C08G65/34 ,  C08G65/48 ,  C08G83/004

摘要： It is provided a polyglycerol derivative, comprising a dendritic polyglycerol backbone and at least one substituent in the nature of a covalently bound negatively charged group chosen from the group consisting of sulfates, sulfonates, phosphates, phosphonates, bisphosphonates, carboxylates and combinations thereof. The substituent is bound to the polyglycerol backbone via a linker, the linker being chosen from the group consisting of moieties being or comprising a carbamate group, an ester group, an orthoester group, an amide group, a disulfide bridge group, an acetal group, an imine group and combinations thereof.

公开(公告)号：EP2992038B1

公开(公告)日：2017-11-29

申请号：EP14721827.5

申请日：2014-04-30

申请人： BASF SE

发明人： WEBER, Martin ,  WEIß, Thomas ,  MALETZKO, Christian ,  STAAL, Bastiaan Bram Pieter ,  MÜHLBACH, Klaus ,  ERBES, Jörg

IPC分类号： B01D71/68 ,  B01D71/80 ,  C08G75/23 ,  C08G81/02 ,  C08G65/334 ,  C08L71/00 ,  C08L71/02 ,  C08L81/06

CPC分类号： C08G75/23 ,  B01D71/68 ,  B01D71/80 ,  C08G65/334 ,  C08G65/3344 ,  C08G65/3346 ,  C08L71/00 ,  C08L71/02