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    PROTEIN-POLYMER-DRUG CONJUGATES
    2.
    发明公开
    PROTEIN-POLYMER-DRUG CONJUGATES 审中-公开
    蛋白质 - 聚合物 - 药物共轭物

    公开(公告)号：EP3228325A1

    公开(公告)日：2017-10-11

    申请号：EP17159707.3

    申请日：2012-06-11

    申请人： Mersana Therapeutics, Inc.

    发明人： YURKOVETSKIY, Aleksandr ,  YIN, Mao ,  LOWINGER, Timothy B ,  THOMAS, Joshua D ,  HAMMOND, Charles E ,  STEVENSON, Cheri A ,  BODYAK, Natalya D ,  CONLON, Patrick R ,  GUMEROV, Dmitry R

    IPC分类号： A61K47/59 ,  A61K47/68 ,  A61K47/64 ,  A61P35/00

    CPC分类号： A61K47/6849 ,  A61K31/4745 ,  A61K47/59 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6883 ,  C07K7/02 ,  C07K16/32 ,  C08G65/33396 ,  C08G65/334

    摘要： A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier comprising poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF) substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L p . Each occurrence of D is independently a therapeutic agent having a molecular weight ≤ 5 kDa, L D and L p are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds comprising PHF useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates of their compositions.

    摘要翻译： 本文提供了药物缀合物。 缀合物包含基于蛋白质的识别分子（PBRM）和包含被一个或多个-LD-D取代的聚（1-羟基甲基乙烯羟甲基 - 缩甲醛）（PHF）的聚合物载体，基于蛋白质的识别分子连接到聚合物 载体由Lp。 每次出现的D独立地是分子量≤5kDa的治疗剂，LD和Lp分别是连接治疗剂和PBRM与聚合物载体的连接子。 还公开了包含可用于与PBRM缀合以形成本文所述的聚合物 - 药物 - PBRM缀合物的PHF的聚合物支架，包含所述缀合物的组合物，其制备方法以及用它们的组合物的缀合物治疗各种病症的方法。

    HYDROPHILIZED POLYALKYLENE GLYCOL, PRODUCTION METHOD THEREOF, AND APPLICATION THEREOF
    9.
    发明公开
    HYDROPHILIZED POLYALKYLENE GLYCOL, PRODUCTION METHOD THEREOF, AND APPLICATION THEREOF 审中-公开
    亲水性聚工艺及其制造及应用

    公开(公告)号：EP1937750A1

    公开(公告)日：2008-07-02

    申请号：EP06798492.2

    申请日：2006-09-26

    申请人： Nippon Shokubai Co., Ltd.

    发明人： HEMMI, Akiko ,  YONEDA, Atsuro

    IPC分类号： C08G65/32 ,  B01F17/42 ,  C07C303/20 ,  C07C309/10 ,  C08G65/326 ,  C11D3/37

    CPC分类号： C07C305/10 ,  B01F17/0028 ,  C08G65/334 ,  C08G65/335 ,  C08L71/02 ,  C11D3/3707

    摘要： To provide: a hydrophilized polyalkylene glycol which is preferably used in various applications, and sufficiently exhibits high performances such as detergency; a production method thereof; and an application thereof. A hydrophilized polyalkylene glycol represented by the following formula (1): in the formula, X1 and Y1 being different from each other, and each representing a hydrogen atom, -SO3M, -S-CH2-CH2-SO3M, -PO3M2, or -S-(CH2)t-COOM; R1 to R6 representing a hydrogen atom or an alkyl group; R7 representing a hydrogen atom, an alkyl group, an aryl group, a polyhydric alcohol group, Z1 or Z2 represented by the following formula (2-2) or (2-2); p, q, r, and s representing a valency; in the formula, X2 and Y2 being different from each other, and each representing a hydrogen atom, -SO3M, -S-CH2-CH2-SO3M, -PO3M2, or -S-(CH2)t-COOM; R8 and R9 representing a hydrogen atom or an alkyl group; and R10 representing an alkyl group or an aryl group.

    Molecules suitable for binding to a metal layer for covalently immobilizing biomolecules
    10.
    发明公开
    Molecules suitable for binding to a metal layer for covalently immobilizing biomolecules 有权
    用于生物分子的共价固定化结合金属层合适的分子

    公开(公告)号：EP1798250A2

    公开(公告)日：2007-06-20

    申请号：EP06026155.9

    申请日：2006-12-18

    申请人： INTERUNIVERSITAIR MICROELEKTRONICA CENTRUM vzw (IMEC)

    发明人： Frederix, Filip ,  Bonroy, Kristin ,  Jans, Karolien

    IPC分类号： C08G65/00

    CPC分类号： G01N33/54353 ,  B05D1/185 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08G65/329 ,  C08G65/334 ,  G01N33/54373 ,  G01N2610/00 ,  Y10T29/49002 ,  Y10T428/24

    摘要： The present invention provides materials and devices for immobilizing functional organic bio-molecules through a covalent bond via a thiolate or disulfide monolayer to a metal surface wherein an extra activation step of the surface layer or an activation step of the functional bio-molecules or bio-receptors is avoided. The mono-layer can contain two moieties, one having a group that resist non-specific adsorption and another group that directly reacts with functional groups on the bio-molecules. In addition, poly(ethylene oxide) groups are incorporated in the monolayer surfaces in order to resist the non-specific adsorption and to enhance specific affinity interactions. The invention also provides a sensor device for performing reproducible, sensitive, specific and stable bio-analysis.

    摘要翻译： 本发明提供的材料和设备，用于经由硫醇或二硫化物单层至表面层的上或功能性有机分子或生物的活化步骤额外活化步骤的金属表面worin通过共价键固定功能性有机生物分子 受体是可以避免的。 单层可以包含两个部分，具有一组一个没有抗蚀剂的非特异性吸附而另一组没有直接与所述生物分子的官能团发生反应。 另外，聚（环氧乙烷）基团被结合到单层表面以抵抗非特异性吸附，并提高特定亲和力相互作用。 因此本发明提供用于执行再现的，灵敏，特异且稳定的生物分析的传感器装置。