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    INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE
    62.
    发明公开
    INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE 审中-公开
    杀虫蛋白及其使用方法

    公开(公告)号：EP3207143A1

    公开(公告)日：2017-08-23

    申请号：EP15790338.6

    申请日：2015-10-14

    Applicant: Pioneer Hi-Bred International, Inc. ,  E. I. du Pont de Nemours and Company

    Inventor： BARRY, Jennifer K. ,  CLARK, Deborah W. ,  ENGLISH, James J. ,  ONG, Azalea ,  SCHEPERS, Eric J. ,  QI, Julie ,  RICE, Janet A.

    IPC: C12N15/82 ,  C07K14/415 ,  A01N65/00

    CPC classification number: C07K14/415 ,  A01N37/46 ,  A01N47/44 ,  A01N65/00 ,  A01N65/04 ,  C07K2319/00 ,  C12N15/8286 ,  Y02A40/162

    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

    Abstract translation: 提供了用于防治害虫的组合物和方法。 该方法涉及用编码杀虫蛋白质的核酸序列转化生物体。 特别地，核酸序列可用于制备具有杀虫活性的植物和微生物。 因此，提供了转化的细菌，植物，植物细胞，植物组织和种子。 组合物是杀虫核酸和细菌物种的蛋白质。 该序列可用于构建表达载体，用于随后转化成感兴趣的生物体，包括植物，作为分离其他同源（或部分同源）基因的探针。 杀虫蛋白质可用于控制，抑制鳞翅目，鞘翅目，双翅目，真菌，半翅目和线虫害虫种群的生长或杀死以及用于产生具有杀虫活性的组合物。

    RECODED ARBOVIRUS AND VACCINES
    63.
    发明公开
    RECODED ARBOVIRUS AND VACCINES 审中-公开
    经过修复的麻疹病毒和疫苗

    公开(公告)号：EP3189136A1

    公开(公告)日：2017-07-12

    申请号：EP15838658.1

    申请日：2015-09-08

    Applicant: The Research Foundation for The State University of New York

    Inventor： WIMMER, Eckard ,  MUELLER, Steffen ,  FUTCHER, Bruce ,  SHEN, Sam ,  STAUFT, Charles ,  WARD, Charles

    IPC: C12N7/00 ,  C12N7/01 ,  A61K39/12 ,  A01N65/00

    CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  C12N2760/12234 ,  C12N2760/12262 ,  C12N2760/20062 ,  C12N2770/24121 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24162 ,  C12N2800/22 ,  Y02A50/386

    Abstract: This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the attenuated virus.

    Abstract translation: 本发明提供了包含经修饰的病毒基因组的减毒病毒，所述病毒基因组经工程改造而含有多个核苷酸置换，所述多个核苷酸置换降低病毒蛋白质编码序列相对于第一个宿主的密码子对偏倚，而相对于第二个宿主的密码子对偏倚实质上没有降低。 在另一个实施方案中，本发明提供了包含经修饰的病毒基因组的减毒病毒，所述病毒基因组经改造以含有多个核苷酸取代，所述多个核苷酸取代相对于第一宿主和第二宿主降低编码病毒蛋白的序列的密码子对偏倚。 减毒病毒可用于疫苗组合物中以在受试者中诱导保护性免疫应答。 本发明还提供了合成减毒病毒的方法。 此外，本发明进一步提供了用于预防对象患病毒相关疾病的方法，包括给予对象预防有效剂量的包含减毒病毒的疫苗组合物。

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