公开(公告)号：EP1322597A4

公开(公告)日：2005-10-19

申请号：EP01975197

申请日：2001-09-12

申请人： SMITHKLINE BEECHAM CORP

发明人： ELDRIDGE ANN M ,  HIEBL JOHANN

IPC分类号： C07D207/404 ,  A61K47/48 ,  C07C319/22 ,  C07C319/24 ,  C07C323/52 ,  C07C323/60 ,  C07D207/46 ,  C07C231/10

CPC分类号： C07D207/46 ,  A61K47/6803 ,  C07C319/22 ,  C07C319/24 ,  C07C323/60 ,  C07C323/52

摘要： Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.

公开(公告)号：EP1474386A1

公开(公告)日：2004-11-10

申请号：EP03737225.7

申请日：2003-02-05

申请人： Delmar Chemicals Inc.

发明人： LIU, Lu, Wei ,  WANG, Yuan ,  MARRUGO, Herika ,  HARPER, Sylvain ,  QUAN, David, D. C. ,  ZHOU, Zhihong (Nancy) ,  BYDLINSKI, Gregory

IPC分类号： C07C319/06 ,  C07C319/24 ,  C07C233/08 ,  C07D307/94 ,  C07C323/53

CPC分类号： C07D307/94

摘要： A process for the preparation of highly pure 1-(mercaptomethyl)-cyclopropaneacetic acid is described. Treatment of 1-(hydroxymethyl)-cyclopropaneacetonitrile with an acid provides the corresponding imino ester and/or halo-amide, which when reacted with thiourea provides the corresponding amide-isothiuronium salt. Hydrolysis of the amide-isothiuronium salt followed by an in situ oxidation allows the facile isolation and purification of 1-[1-(carboxymethyl)-cyclopropanemethyldisulfanylmethyl]-cyclopropaneacetic acid (also known as 1-(mercaptomethyl)-cyclopropaneacetic acid disulfide). Reduction of the 1-(mercaptomethyl)-cyclopropaneacetic acid disulfide under mild conditions provides the 1-(mercaptomethyl)-cyclopropaneacetic acid with high purity.

公开(公告)号：EP1137630A4

公开(公告)日：2004-09-08

申请号：EP99967269

申请日：1999-12-10

申请人： CONOCOPHILLIPS CO

发明人： SWINDELL HAROLD J ,  MATSON MICHAEL S

IPC分类号： C07C319/24 ,  C07C321/14 ,  C07C321/00

CPC分类号： C07C319/24 ,  C07C321/14

摘要： A process which can be used to produce an organic disulfide is provided. The process comprises contacting a mercaptan in the presence of an oxygen-containing fluid, a catalyst, optionally a cocatalyst, and further optionally a solvent or a surfactant or combination of a solvent and surfactant under a condition sufficient to oxidize the mercaptan to an organic disulfide.

公开(公告)号：EP1149813B1

公开(公告)日：2004-06-23

申请号：EP01400833.8

申请日：2001-04-02

申请人： Atofina

发明人： Luyendijk, Piet ,  Devaux, Jean-Francois ,  Monguillon, Bernard

IPC分类号： C07B45/06 ,  C07C319/24 ,  C07C321/04 ,  C07G17/00

CPC分类号： C07C319/04 ,  C07B45/06 ,  C07C319/24 ,  C07G17/004 ,  C07C321/04 ,  C07C321/14

公开(公告)号：EP1149071A4

公开(公告)日：2003-03-19

申请号：EP00902457

申请日：2000-01-21

申请人： PHILLIPS PETROLEUM CO

发明人： SHAW JAMES E

IPC分类号： C07B61/00 ,  C07C319/24 ,  C07C319/26 ,  C07C321/04 ,  C07C321/14 ,  C07C311/00

CPC分类号： C07C319/24 ,  C07C321/14

摘要： A process for producing an organic polysulfide compound comprises contacting, in th presence of a catalyst, a mercaptan with elemental sulfur to produce a product medium and contacting the product medium with a material comprising carbon dioxide or a carbon dioxide-generating compound wherein the catalyst comprises a base and optionally a surfactant and the organic polysulfide contains about 3 or more sulfur atoms per molecule.

公开(公告)号：EP1149829B1

公开(公告)日：2003-01-15

申请号：EP01400834.6

申请日：2001-04-02

申请人： Atofina

发明人： Devaux, Jean-François

IPC分类号： C07C319/24

CPC分类号： C07G17/004 ,  C07C319/24 ,  C07C321/14

公开(公告)号：EP0955302B1

公开(公告)日：2002-06-12

申请号：EP99108397.3

申请日：1999-04-29

申请人： Degussa AG

发明人： Michel, Rudolf ,  Münzenberg, Jörg Dr.

IPC分类号： C07F11/00 ,  C07F7/18 ,  C07C319/24

CPC分类号： C07F7/1892

公开(公告)号：EP1044965A1

公开(公告)日：2000-10-18

申请号：EP99926847.7

申请日：1999-06-30

申请人： Nippon Finechemical Co., Ltd.

发明人： ARAI, Isamu Toda Research Laboratories ,  YAMAGUCHI, Tutomu Toda Research Laboratories ,  HIDA, Yoko Toda Research Laboratories

IPC分类号： C07C319/06 ,  C07C319/24 ,  C07C321/24 ,  C07C323/09 ,  C07C323/64

CPC分类号： C07C319/24 ,  C07C319/06 ,  C07C323/09

摘要： The present invention discloses a process for the preparation of aromatic thiophenol represented by the formula (I):

        Y n -Ar-(SH) m      (I)



wherein Ar represents an aromatic hydrocarbon residue; Y represents at least one kind of substituent bonded to a carbon atom constituting the aromatic ring of Ar, which is selected from the group consisting of halogeno, nitro, nitrile, sulfone, sulfamoyl and hydrocarbylsulfonyl groups; m is an integer of 1 or more; and n is 0 or an integer of 1 or more,
which comprises reacting aromatic thioether represented by the formula (II):

        Y n -Ar-(SR) m      (II)



wherein R represents a monovalent secondary or tertiary hydrocarbyl, or a monovalent primary hydrocarbyl group represented by the formula:

        -CH 2 -R 1 or -CH 2 -CR 2 =C(R 2 ) 2 ;



where R 1 represents a monovalent aromatic ring group optionally substituted by a monovalent hydrocarbyl group, and each of R 2 may be the same as or different from each other and represents hydrogen or a monovalent hydrocarbyl group;

Y, Ar, m and n have the same meanings as defined above, in the presence of (A) a Lewis acid or a protonic acid
provided that in the case of a protonic acid, primary hydrocarbyl group is excluded from R,
and a solvent,
and, if necessary, hydrolyzing the reaction product.

摘要翻译： 本发明公开了一种由式（I）表示的芳族苯硫酚的制备方法：Yn-Ar-（SH）m，其中Ar表示芳烃残基; Y表示与构成芳香环的碳原子键合的至少一种取代基，其选自卤代，硝基，腈，砜，氨磺酰基和烃基磺酰基; m为1以上的整数， n为0或1以上的整数，其包括使由式（II）表示的芳族硫醚：Yn-Ar-（SR）m，其中R表示一价仲或叔烃基，或表示的一价一级烃基 通式为：-CH 2 -R 1或-CH 2 -CR 2 = C（R 2）2; 其中R 1表示任选被一价烃基取代的一价芳族环基团，R 2可以彼此相同或不同，表示氢或一价烃基; 在（A）路易斯酸或质子酸的存在下，Y，Ar，m和n具有与上述相同的含义，条件是在质子酸的情况下，主要烃基不包括在R中，溶剂 ，如果需要，水解反应产物

公开(公告)号：EP0869940B1

公开(公告)日：2000-04-05

申请号：EP96941102.4

申请日：1996-12-03

申请人： ELF AQUITAINE PRODUCTION

发明人： ARRETZ, Emmanuel ,  LOPEZ, Frédéric

IPC分类号： C07C319/24 ,  C07C321/14

CPC分类号： C07C319/24 ,  C07C321/14

摘要： A method for achieving improved conversion rates and/or a faster reaction rate, particularly in reaction (a), than those achievable with prior art resins.

公开(公告)号：EP0583768A1

公开(公告)日：1994-02-23

申请号：EP93113111.4

申请日：1993-08-16

申请人： PHILLIPS PETROLEUM COMPANY

发明人： Shaw, James Edward

IPC分类号： C07C43/11 ,  C07C323/12 ,  C07C319/24 ,  C07C321/14

CPC分类号： C07C319/24 ,  C07C321/14

摘要： A composition comprising a base and an alkoxylated compound selected from an alkoxylated alcohol and alkoxylated mercaptan is disclosed. The composition can be used to catalyze the reaction of a mercaptan and an elemental sulfur to produce a polysulfide compound. The polysulfide compound can be further treated with an alkylene oxide to reduce the mercaptan sulfur content of the polysulfide compound.

摘要翻译： 公开了一种包含碱和选自烷氧基化醇和烷氧基化硫醇的烷氧基化化合物的组合物。 该组合物可用于催化硫醇和元素硫的反应以产生多硫化合物。 可以用环氧烷进一步处理多硫化合物以降低多硫化物化合物的硫醇硫含量。