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公开(公告)号：EP1622901A1
公开(公告)日：2006-02-08
申请号：EP04729423.6
申请日：2004-04-26
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas , SIFFERLEN, Thierry
IPC分类号： C07D451/02 , A61K31/46
CPC分类号： C07D451/02
摘要： The invention relates to novel tropane derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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72.发明公开TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS 有权用作OREXIN受体拮抗剂的四氢异喹啉乙酰胺衍生物
公开(公告)号：EP1611104A1
公开(公告)日：2006-01-04
申请号：EP04722563.6
申请日：2004-03-23
发明人： AISSAOUI, Hamed , CLOZEL, Martine , WELLER, Thomas , KOBERSTEIN, Ralf , SIFFERLEN, Thierry , FISCHLI, Walter
IPC分类号： C07D217/02 , C07D217/18 , C07D217/20 , C07D405/06 , C07D217/04 , C07D217/16 , A61P3/04 , A61P25/20 , A61K31/472
CPC分类号： C07D217/02 , C07D217/04 , C07D217/16 , C07D217/18 , C07D217/20 , C07D405/06
摘要： The invention relates to novel acetamide derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的新型乙酰胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及相关方面，包括制备这些化合物的方法，含有一种或多种这些化合物的药物组合物，特别是它们作为食欲素受体拮抗剂的用途。
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73.发明公开SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS 有权维生素ALS OREXIN REZEPTOR ANTAGONISTE中的苯磺酰胺氧化酶
公开(公告)号：EP1554239A2
公开(公告)日：2005-07-20
申请号：EP03785607.7
申请日：2003-10-06
发明人： AISSAOUI, Hamed , CLOZEL, Martine , WELLER, Thomas , KOBERSTEIN, Ralf , SIFFERLEN, Thierry , FISCHLI, Walter,ACTELION Pharmaceuticals Ltd.
IPC分类号： C07C311/13 , C07C311/20 , C07C311/21 , C07D207/335 , C07D209/14 , C07D213/76 , C07D213/75 , C07D215/36 , C07D215/38 , C07D217/04 , C07D217/12 , C07D231/56 , C07D233/61 , C07D277/28
CPC分类号： C07C311/21 , A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473 , C07C311/13 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07D207/323 , C07D209/14 , C07D213/40 , C07D213/53 , C07D213/71 , C07D213/74 , C07D213/75 , C07D215/12 , C07D215/36 , C07D215/38 , C07D217/02 , C07D231/56 , C07D233/64 , C07D277/28 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新型磺酰基氨基 - 乙酸衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这些化合物的方法，包含一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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公开(公告)号：EP1465875A1
公开(公告)日：2004-10-13
申请号：EP02795133.4
申请日：2002-12-10
IPC分类号： C07D239/47 , A61K31/506 , A61P9/00 , C07D239/56 , C07D239/52 , C07D239/48 , C07D401/14 , C07D403/14
摘要： The invention relates to novel alkansulfonamides of structure (I), wherein R1 is a lowel alzyl group and the other variables are as defined in the description, and their use as active ingredients in the preparation of pharmaceutical compositions. The invention aslo concerns related aspects inluding processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists in the treatment and prevention of diseases associated to the endothelin system.
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公开(公告)号：EP3897646B1
公开(公告)日：2024-05-22
申请号：EP19832954.2
申请日：2019-12-20
IPC分类号： A61K31/506 , A61P9/12 , A61P11/00
CPC分类号： A61K31/506 , A61P11/00 , A61P9/12
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公开(公告)号：EP3256125B1
公开(公告)日：2022-01-26
申请号：EP15807916.0
申请日：2015-12-10
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公开(公告)号：EP3592391B1
公开(公告)日：2021-04-21
申请号：EP18711258.6
申请日：2018-03-07
IPC分类号： A61K47/10 , A61K9/19 , A61K31/4965 , A61P17/02 , A61P9/12
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公开(公告)号：EP3310767B1
公开(公告)日：2020-07-22
申请号：EP16734754.1
申请日：2016-06-21
发明人： AISSAOUI, Hamed , BOLLI, Martin , BOSS, Christoph , RICHARD-BILDSTEIN, Sylvia , SIEBER, Patrick
IPC分类号： C07D417/14 , C07D471/10 , C07D491/107 , C07D263/58 , C07D263/54 , C07D277/62 , C07D413/14 , C07D413/12 , C07D417/12
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公开(公告)号：EP3227263A1
公开(公告)日：2017-10-11
申请号：EP15801467.0
申请日：2015-11-30
IPC分类号： C07D223/16 , A61K31/55 , A61K31/5513 , A61K31/553 , C07D243/14 , C07D267/14
CPC分类号： C07D417/12 , A61K31/553 , A61K45/06 , C07D223/16 , C07D243/14 , C07D267/14 , C07D405/12 , C07D405/14
摘要： wherein (R1)n, ring (A), Y1, Y2, X, R4, L1, L2, and A1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
摘要翻译： 本发明涉及式（I）的衍生物，其中（R 1）n，环（A），Y 1，Y 2，X，R 4，L 1，L 2和Ar 1如描述中所述， 它们的制备，药学上可接受的盐，以及它们作为药物的用途，含有一种或多种式（I）化合物的药物组合物，特别是它们作为CXCR7受体调节剂的用途。
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80.发明公开PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS 审中-公开PYRAZOLVERBINDUNGEN UND DEREN VERWENDUNG ALS T-TYP-CALCIUMKANALBLOCKER
公开(公告)号：EP3152199A1
公开(公告)日：2017-04-12
申请号：EP15728640.2
申请日：2015-06-02
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D231/40 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , A61K31/415 , A61K31/4155 , A61K31/4439 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P35/00
CPC分类号： C07D231/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D471/04
摘要： wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
摘要翻译： 其中X，Y，R 1，R 2，（R 4）n和（R 5）m如说明书中所定义，以及这些化合物的药学上可接受的盐。 这些化合物可用作钙T通道阻滞剂。
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