公开(公告)号：EP2254850A2

公开(公告)日：2010-12-01

申请号：EP09713167.6

申请日：2009-02-16

申请人： Bracco Imaging S.p.A

发明人： LATTUADA, Luciano ,  CAVALLOTTI, Camilla ,  GIOVENZANA, Giovanni, Battista ,  UGGERI, Fulvio

IPC分类号： C07B39/00 ,  C07C67/307 ,  C07C231/12 ,  C07C233/69 ,  C07C69/88

CPC分类号： C07C51/363 ,  C07B39/00 ,  C07C37/62 ,  C07C67/307 ,  C07C231/12 ,  C07C237/46 ,  C25B3/06 ,  C07C65/03 ,  C07C69/88 ,  C07C235/48 ,  C07C39/27

摘要： The present invention relates to a process for the preparation of iodinatedphenols,- in particular, it relates to a process including the electrochemical iodination of 3,5- disubstituted phenols of formula (1) to the corresponding 3, 5-disubstituted-2,4, 6- triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5-disubstituted anilines of formula (6) to the corresponding 3, 5-disubstituted-2,4, 6-triiodoanilins of formula (7).

公开(公告)号：EP2162861A1

公开(公告)日：2010-03-17

申请号：EP08774636.8

申请日：2008-07-02

申请人： Bracco Imaging S.p.A

发明人： BUSCEMA, Paolo Massimo

IPC分类号： G06T5/00

CPC分类号： G06T5/003 ,  G06T7/13 ,  G06T2207/20084

摘要： Image processing method that includes the steps of considering each image point as a node of an artificial neural network, and of processing the image as function of values of the nodes and of connections of each image point undergoing processing with neighboring image points, the image points of the processed image being obtained by iterative evolution steps of parameters defining the appearance as evolution steps of the value of nodes or by iterative evolution steps of values of the set of connections or by a combination of the evolutions, wherein the processing occurs by evolution iterative steps that are functions of connections of neighboring image points with the image point under examination, each of the neighboring image points being further considered as neighboring one or more or all adjacent image points, the functions providing immediate feedback contributions for determining appearance values of all other image points.

摘要翻译： 图像处理方法，其包括以下步骤：将每个图像点视为人造神经网络的节点，并且处理图像作为节点数值的函数以及与相邻图像点进行处理的每个图像点的连接，图像点 通过将外观的定义为节点值的演化步骤的参数的迭代演化步骤或连接组的值的迭代演化步骤或演化的组合来获得经处理的图像，其中处理通过进化迭代 作为相邻图像点与被检查图像点的连接的功能的步骤，每个相邻图像点进一步被认为是相邻的一个或多个或所有相邻图像点，所述功能提供用于确定所有其他的外观值的即时反馈贡献 图像点。

公开(公告)号：EP2147684A1

公开(公告)日：2010-01-27

申请号：EP08160856.4

申请日：2008-07-22

申请人： Bracco Imaging S.p.A

发明人： Rossello, Armando ,  Avramova, Stanislava Ivanova ,  Nuti, Elisa ,  Uggeri, Fulvio ,  Maiocchi, Alessandro

IPC分类号： A61K49/00 ,  A61K49/10 ,  A61K49/22 ,  A61K51/04 ,  A61P43/00

CPC分类号： A61K49/0017 ,  A61K49/085 ,  A61K49/10 ,  A61K49/101 ,  A61K49/103 ,  A61K49/105 ,  A61K49/106 ,  A61K49/221 ,  A61K51/0497

摘要： The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below

wherein R, R 1 , R 2 , R 3 , G and n have the meanings reported in the specification, properly labelled with diagnostic imaging moieties or even radiotherapeutic moieties. The invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as diagnostic imaging agents or radiotherapeutic agents.

摘要翻译： 本发明涉及对金属蛋白酶MMP具有亲和力的芳基磺酰氨基化合物，其具有式（I），其中R，R 1，R 2，R 3，G和n具有说​​明书中报道的含义，适当地用诊断成像 部分或甚至放射治疗部分。 本发明还涉及其制备方法，包含它们的药物组合物及其作为诊断显像剂或放射治疗剂的用途。

公开(公告)号：EP1786475B1

公开(公告)日：2009-04-29

申请号：EP05772650.7

申请日：2005-06-28

申请人： Bracco Imaging S.p.A

发明人： AIME, Silvio ,  GALLI, Matteo ,  LATTUADA, Luciano ,  MOROSINI, Pierfrancesco ,  UGGERI, Fulvio ,  KONDAREDDIAR, Ramalingam

IPC分类号： A61K49/00

CPC分类号： C07H15/26 ,  A61K49/085 ,  A61K49/124 ,  C07C237/08 ,  C07D243/08 ,  C07D243/10 ,  C07F9/3808 ,  C07F9/4006 ,  C07F9/5728 ,  C07H17/02

摘要： The present invention relates to a novel class of ligands for use in paramagnetic ion-based contrast agents of formula e (III) or (IIIa) wherein: R is, independently, H or a C2-C70 aminopolyol moiety comprising a straight or branched alkyl chain substituted by from 2 to 30 hydroxyl groups, said chain being optionally interrupted by one or more groups selected from -0-, -NH-, -N NC0-; and optionally substituted by one or more C4-C10 cyclic units; L is, independently, a direct bond or a divalent straight or branched linker moiety between R and the rest of the molecule, comprising at most 20 carbon atoms; v is a positive integer from 1 to 7; together with the corresponding protonated forms of the phosphonate (-PO3H2) and carboxy (-COOH) groups; or a physiologically acceptable salt of such ligand; with the proviso that at least one of the R groups is other than H; the contrast agents show a pharmacokinetic profile analogous to that of the commonly used Tl -general extravascular agents (NSA) but are further characterized by a higher relaxivity.

公开(公告)号：EP2035089A1

公开(公告)日：2009-03-18

申请号：EP07786897.4

申请日：2007-06-28

申请人： Bracco Imaging S.p.A

发明人： MATTIUZZI, Marco ,  CASCINI, Gaetano ,  RUSSO, Davide

IPC分类号： A61N5/06

CPC分类号： A61B18/22 ,  A61B18/20 ,  A61B2017/00084 ,  A61B2018/00636 ,  A61B2018/2261 ,  A61B2018/2283 ,  A61N5/0601 ,  A61N7/00

摘要： Device for localized thermal ablation of lesion tissues, particularly tumoral tissues or the like, which device comprises: a probe or needle intended to be positioned with the end tip at the lesion tissue or tumoral tissue area to be removed; which probe or needle support at least a light guide as an elongated member like a thin wire or thread, one of the ends thereof is an end emitting heating electromagnetic energy and which light guide ends at said end of the probe or needle by a tip irradiating said electromagnetic energy, particularly as a laser light and the other end thereof is connected to a source generating the electromagnetic energy; means for controlling the activation/deactivation of the source generating the electromagnetic energy. Characterized in that in combination it comprises means for the controlled distribution of the heating action on the lesion tissue area generated by the electromagnetic energy emitted by the irradiating tip inside a volume having a predetermined size. The invention relates also to a method for localized thermal ablation.

摘要翻译： 该装置用于对损伤组织，特别是肿瘤组织等进行局部热消融，该装置包括：探针或针，其用于定位，其末端位于待去除的病变组织或肿瘤组织区域处; 该探针或针支撑至少一个光导作为如细线或细丝那样的细长构件，其中一个端部是发射加热电磁能量的端部，并且该光导在探针或针的末端通过尖端照射 所述电磁能量，特别是作为激光，而其另一端连接到产生电磁能的源; 用于控制产生电磁能量的源的激活/去激活的装置。 其特征在于，它包括用于在由具有预定尺寸的体积内由照射尖端发射的电磁能产生的病变组织区域上受控分布加热作用的装置。 本发明还涉及用于局部热消融的方法。

公开(公告)号：EP1560600B1

公开(公告)日：2009-01-21

申请号：EP03779875.8

申请日：2003-11-10

申请人： BRACCO IMAGING S.p.A.

发明人： DE HAEN, Christoph, Bracco Imaging S.p.A. ,  MAISANO, Federico, Bracco Imaging S.p.A.

IPC分类号： A61K47/48

CPC分类号： B82Y5/00 ,  A61K47/6887 ,  A61K47/6897 ,  A61K51/1093

摘要： The invention provides chemical conjugates between an immunoglobulin Fab fragment and molecular entities imparting diagnostic or therapeutic utility, whereby the only sites of conjugation on the Fab fragment are one s or both of the sulfhydryl groups deriving from the selective and quantitative reduction of the inter-chain disulfide bond of said Fab fragment and whereby said molecular entities imparting diagnostic or therapeutic utility have at least one free sulfllydryl-reactive group, characterized in that the conjugation stoichiometric molar ratio molecular entity to Fab fragment is in the range from 0.95 to 1.05 or in the range from 1.95 to 2.05. The invention also provides a process for preparing said conjugates and pharmaceutical compositions thereof.

公开(公告)号：EP1509254B1

公开(公告)日：2009-01-14

申请号：EP03735518.7

申请日：2003-06-02

申请人： BRACCO IMAGING S.p.A.

发明人： AIME, S.; c/o Bracco Imaging S.p.A. ,  MAINERO, V.; c/o Bracco Imaging S.p.A. ,  GENINATTI, Chrich S.; c/o Bracco Imaging S.p.A. ,  CABELLA, C.; c/o Bracco Imaging S.p.A.

IPC分类号： A61K49/08 ,  A61K41/00

CPC分类号： C07C237/12 ,  A61K41/009 ,  A61K41/0095 ,  A61K49/085 ,  C07C237/10 ,  C07C271/22 ,  C07C279/12 ,  C07C279/14

摘要： The invention provides MRI detectable species of formula (I): Dp-Sn-Nm, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer; m is an integer and p is an integer. These compounds are useful for internalising into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalised in normal healthy cells thus allowing the diagnosis of tumors. The internalisation of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.

公开(公告)号：EP1539249B1

公开(公告)日：2008-07-09

申请号：EP03765080.1

申请日：2003-07-22

申请人： BRACCO IMAGING S.p.A.

发明人： AIME, Silvio ,  GENINATTI CRICH, Simonetta ,  LATTUADA, Luciano

IPC分类号： A61K49/12 ,  A61K49/18

CPC分类号： A61K49/12 ,  A61K49/101 ,  A61K49/105 ,  A61K49/1839 ,  A61K49/1863 ,  A61K49/1896

摘要： The present invention relates to paramagnetic complexes based on lantanides or transition metals administered in the form of particulates internalysed by cells and whose presence in the cells can be detected by MRI techniques.

公开(公告)号：EP1412383B9

公开(公告)日：2007-10-03

申请号：EP02764797.3

申请日：2002-07-26

申请人： BRACCO IMAGING S.p.A.

发明人： AIME, Silvio ,  GIANOLIO, Eliana ,  MORELLI, Giancarlo ,  PEDONE, Carlo ,  TESAURO, Diego ,  LATTUADA, Luciano ,  VISIGALLI, Massimo ,  ANELLI, Pier, Lucio

IPC分类号： C07K14/595 ,  C07K14/655 ,  C07C237/12 ,  C07F9/38 ,  A61K38/04 ,  A61K51/08 ,  G01N33/68 ,  C07F9/572

CPC分类号： A61K49/14 ,  A61K49/085 ,  C07K14/595 ,  C07K14/655

摘要： The present invention relates to a novel class of contrast agents for use in nuclear magnetic resonance (MRI), to identify and locate primary human tumours and their metastases which over-express type CCK A and/or type B cholecystokinin receptors, and/or type SSTR 1-5 somatostatin receptors.

公开(公告)号：EP1815436A1

公开(公告)日：2007-08-08

申请号：EP05815703.3

申请日：2005-11-28

申请人： Bracco Imaging S.P.A.

发明人： ZHOU, Luping ,  YAPENG, Wang ,  GOH LIN, Chia

IPC分类号： G06T7/60

CPC分类号： G06K9/00201 ,  G06T7/13 ,  G06T7/155 ,  G06T7/62 ,  G06T2207/20044 ,  G06T2207/30101 ,  G06T2207/30172

摘要： Various methods for automatically generating a structured clinical report by using a pre-defined template structure and mapping it to the imaging data set of an organ (such as a CT or MR scan) are presented. A template or knowledge structure may describe the general structure of a tube- like organ, and may be based on prior knowledge related to acceptable ranges of measurement or rations for a particular organ or area of interest. The organ of interest may be segmented out from original image slices. In exemplary embodiments of the present invention a corresponding centerline can be calculated and a skeleton of the tube-like o rgan can be created. Based on the centerline extracted, a knowledge structure (template) can be mapped to the organ data. Since required measurements may be defined in the template, actual measurements can be automatically calculated for th e structure. Such measurements may be further refined in a three dimensional environment, and can be used to form a structured clinical report for further use.

摘要翻译： 用于通过使用预定义的模板结构自动生成的结构化临床报告，并将其映射到所述成像数据集的器官的各种方法（：诸如CT或MR扫描）被呈现。 模板或知识结构可以描述管状器官的一般结构，并且可以基于与可接受的测量或口粮范围为特定器官或感兴趣区域的先验知识。 感兴趣的器官可以从原始图像切片进行分割出去。 在本发明的示例性实施例的相应的中心线可以计算并且可以创建在管状器官的骨架。 基于中心线萃取，一个知识结构（模板）可以被映射到所述器官的数据。 因为需要测量可以在模板中所定义，实际测量可以自动计算的结构。 搜索测量可以进一步细化在三维环境中，并且可以用来形成进一步使用结构化临床报告。