公开(公告)号：EP2974699A1

公开(公告)日：2016-01-20

申请号：EP15002247.3

申请日：2004-04-16

申请人： The Children's Hospital of Philadelphia ,  Drexel University

发明人： Levy, Robert J. ,  Chorny, Michael ,  Fishbein, Ilia ,  Alveriev, Ivan ,  Friedman, Gennady ,  Barbee, Kenneth A. ,  Yellen, Benjamin B. ,  Forbes, Zachary G.

IPC分类号： A61F2/82

CPC分类号： A61K9/0009 ,  A61F2/82 ,  A61F2210/009 ,  A61F2250/0067 ,  A61K9/0024 ,  A61K9/5146 ,  A61K9/5153 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/622 ,  A61L2300/624 ,  C08F8/10 ,  C08F8/30 ,  C08F8/34 ,  C08F126/02 ,  C08F8/32 ,  C08F120/06

摘要： Magnetizable implantable devices and methods for their use in delivery of therapeutic agents encapsulated or dispersed in a magnetic carrier to a selected site of implantation in a subject are provided.

摘要翻译： 提供了可磁化的可植入装置及其用于将包封或分散在磁性载体中的治疗剂递送至受试者的选定植入部位的方法。

公开(公告)号：EP2928843A1

公开(公告)日：2015-10-14

申请号：EP13860163.8

申请日：2013-12-03

申请人： Drexel University

发明人： BARSOUM, Michel, W. ,  GOGOTSI, Yury ,  ABDELMALAK, Michael, Naguib ,  MASHALIR, Olha

IPC分类号： C04B35/56

CPC分类号： C04B35/58021 ,  C04B35/5607 ,  C04B35/5618 ,  C04B2235/3201 ,  C04B2235/3203 ,  C04B2235/3206 ,  C04B2235/3284 ,  C04B2235/448 ,  C04B2235/449 ,  H01G11/04 ,  H01G11/26 ,  H01G11/50 ,  H01G11/86 ,  H01M4/58 ,  H01M10/052 ,  Y02E60/13

摘要： The present invention is directed to compositions comprising free standing and stacked assemblies of two dimensional crystalline solids, and methods of making the same. Typically, two-dimensional, 2-D, free-standing crystals exhibit properties that differ from those of their three-dimensional, 3-D, counterparts. Currently, however, there are relatively few materials which can be described as 2-D, atomically-scaled layered solids. Clearly the most studied freestanding 2-D material is graphene, but other materials include hexagonal BN, certain transition metal oxides, hydroxides, and silicates, including clays, S2N, MoS2 and WS2 are also known.

公开(公告)号：EP2108133B1

公开(公告)日：2015-08-26

申请号：EP08728429.5

申请日：2008-01-29

申请人： Drexel University

发明人： HICKS, Robert Andrew

IPC分类号： G02B5/10 ,  B60R1/08

CPC分类号： G02B5/10 ,  B60R1/082

公开(公告)号：EP2874997A2

公开(公告)日：2015-05-27

申请号：EP13819583.9

申请日：2013-07-18

申请人： Drexel University

发明人： KIM, Felix J. ,  SALVINO, Joseph M.

IPC分类号： C07C277/00

CPC分类号： A61K31/155 ,  A61K9/06 ,  A61K9/7023 ,  A61K31/138 ,  A61K31/366 ,  A61K31/4035 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/69 ,  A61K45/06 ,  C07C279/18 ,  C07D209/48 ,  C07D311/16 ,  A61K2300/00

摘要： The present invention includes compounds useful in preventing, treating or ameliorating Sigma-related disorders or diseases. The compounds of the invention can modulate cellular protein homeostasis, which includes: translation initiation, folding, processing, transport, and degradation (including ubiquitin selective autophagy) of proteins. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound, further comprising administering an effective amount of a compound that inhibits the ubiquitin proteasome system (UPS) and/or autophagic survival pathways.

公开(公告)号：EP2854832A2

公开(公告)日：2015-04-08

申请号：EP13797412.7

申请日：2013-05-31

申请人： Drexel University ,  Baruch S. Blumberg Institute

发明人： CHANG, Jinhong ,  BLOCK, Timothy M. ,  KINNEY, William A. ,  GUO, Ju-Tao. ,  ALMOND, Harold.R.

IPC分类号： A61K38/12 ,  C07K5/00 ,  A01N47/34 ,  C07D245/00

CPC分类号： A61K38/12 ,  A61K31/16 ,  A61K31/165 ,  A61K31/166 ,  A61K45/06 ,  C07K5/123 ,  C07K5/126

摘要： The present invention provides small molecule inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which are useful as therapeutics in the management of chronic HBV. The compounds of the invention achieve epigenetic modification of the cccDNA, histone modification and histone deacetylase activity inhibition, thus modulating HBV cccDNA. The present invention further provides methods for modulating HBV cccDNA, for treating or preventing HBV in a subject, and for modulating cccDNA transcription of hepatitis B in a subject.

公开(公告)号：EP2715354A2

公开(公告)日：2014-04-09

申请号：EP12846223.1

申请日：2012-05-25

申请人： Drexel University ,  Philadelphia Health and Education Corporation ,  Shih, Wei-Heng ,  Shih, Wan Y. ,  Au, Giang ,  Brooks, Ari D. ,  Swami, Vanlila K.

发明人： SHIH, Wei-Heng ,  SHIH, Wan, Y. ,  AU, Giang ,  BROOKS, Ari, D. ,  SWAMI, Vanlila, K.

IPC分类号： G01N33/532 ,  G01N33/574 ,  B82Y15/00 ,  G01N21/63

CPC分类号： G01N33/57488 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C07K16/22 ,  C07K16/30 ,  G01N33/532 ,  G01N33/533 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/57492 ,  G01N33/588 ,  G01N2333/475 ,  G01N2333/705 ,  G01N2400/00 ,  G01N2458/00 ,  Y10S977/774 ,  Y10S977/824 ,  Y10S977/892 ,  Y10S977/927

摘要： One or more aqueous, near infrared emitting, high yield, highly photoluminescent, stable quantum dots conjugated to one or more biomarkers specific moieties. The conjugated quantum dots have an enhanced detection sensitivity and selectivity and may be formed using a novel and efficient method for conjugating one or more biomarker specific moieties to the quantum dots. The invention is further directed to a method for using the conjugated quantum dots for cancer detection in the margin of excised tissue.

摘要翻译： 与一个或多个生物标志物特异性部分缀合的一种或多种含水，近红外发射，高产率，高光致发光，稳定的量子点。 共轭量子点具有增强的检测灵敏度和选择性，并且可以使用用于将一个或多个生物标记特异性部分缀合到量子点的新颖且有效的方法形成。 本发明还涉及一种使用共轭量子点进行切除组织边缘癌症检测的方法。

公开(公告)号：EP2629659A2

公开(公告)日：2013-08-28

申请号：EP11835213.7

申请日：2011-10-21

申请人： Drexel University

发明人： VARMA, Kushal ,  POURSHOGHI, Ahmadreza ,  MAGEE, Nathaniel ,  SHAH, Atman ,  SHAH, Sagar ,  SWOBODA, Marek ,  LEC, Ryszard, M.

IPC分类号： A61B5/02

CPC分类号： A61B5/02233 ,  A61B5/021 ,  A61B5/02116 ,  A61B5/02125 ,  A61B5/22 ,  A61B5/489 ,  A61B5/681 ,  A61B5/6843 ,  A61B5/7235 ,  A61B5/7278 ,  A61B2560/0228

摘要： Blood pressure measurement devices comprising a transducer may have error introduced when the transducer is placed in mechanical communication with a vein or artery. This error may be based on alignment, applanation, calibration, and the contact based stress required to obtain a signal from pressure in a vein or artery. The present invention teaches isolating and removing this error from the blood pressure system which may increase the accuracy of the measurement. Calibration is also provided.

公开(公告)号：EP1977224B1

公开(公告)日：2013-04-03

申请号：EP07762595.2

申请日：2007-01-23

申请人： Drexel University

发明人： MUTHARASAN, Rajakkannu ,  MARALDO, David ,  CAMPBELL, Gossett ,  RIJAL, Kishan

IPC分类号： B06B1/06 ,  G01N29/02 ,  G01N29/036 ,  H01L41/113

CPC分类号： G01N29/022 ,  G01H11/08 ,  G01H13/00 ,  G01N29/036 ,  G01N33/54373 ,  G01N2291/0256 ,  G01N2291/0426 ,  G01N2291/0427 ,  H01L41/1132

公开(公告)号：EP2365007A2

公开(公告)日：2011-09-14

申请号：EP11003742.1

申请日：2004-04-16

申请人： The Children's Hospital of Philadelphia ,  Drexel University

发明人： Levy, Robert J. ,  Chorny, Michael ,  Fischbein, Ilia ,  Alferiev, Ivan ,  Friedman, Gennady ,  Barbee, Kenneth A. ,  Yellen, Benjamin B. ,  Forbes, Zachary G.

IPC分类号： C08F8/00 ,  C08F8/34 ,  A61L31/16 ,  A61L31/18 ,  A61K9/00 ,  A61F2/82 ,  A61K9/51

CPC分类号： A61K9/0009 ,  A61F2/82 ,  A61F2210/009 ,  A61F2250/0067 ,  A61K9/0024 ,  A61K9/5146 ,  A61K9/5153 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/622 ,  A61L2300/624 ,  C08F8/10 ,  C08F8/30 ,  C08F8/34 ,  C08F126/02 ,  C08F8/32 ,  C08F120/06

摘要： Magnetizable implantable devices and methods for their use in delivery of therapeutic agents encapsulated or dispersed in a magnetic carrier to a selected site of implantation in a subject are provided.

摘要翻译： 提供了可磁化的可植入装置及其用于将包封或分散在磁性载体中的治疗剂递送至受试者的选定植入部位的方法。

公开(公告)号：EP2348967A1

公开(公告)日：2011-08-03

申请号：EP09825481.6

申请日：2009-11-06

申请人： Drexel University

发明人： PAPAZOGLOU, Elisabeth, S. ,  ZUBKOV, Leonid

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0077 ,  A61B5/445 ,  A61B5/7228 ,  A61B2560/0223 ,  A61B2562/0242

摘要： A device for measuring the progress of healing of a wound over time includes at least one diode laser source that provides respective input wavelengths into at least one source fiber, a first optical switch that sequentially switches wavelengths among the respective input wavelengths into the at least one source fiber, a probe that does not touch the wound dunng use, the probe including the at least one source fiber and at least two detectors spaced thereon, an optical system that provides source light from the at least one source fiber to the wound and that detects light scattered by the wound surface and provides the scattered light to the detectors, and a processing unit responsive to outputs of the detectors for providing at least four independent measurements for calculation of an absorption coefficient /Ia and a scattering coefficient /I's of the light by the wound