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    Human prourokinase-like polypeptide
    76.
    发明授权
    Human prourokinase-like polypeptide 失效
    人尿激酶原样多肽。

    公开(公告)号：EP0330700B1

    公开(公告)日：1993-12-22

    申请号：EP88907361.5

    申请日：1988-08-18

    申请人： SAGAMI CHEMICAL RESEARCH CENTER ,  CENTRAL GLASS COMPANY, LIMITED ,  HODOGAYA CHEMICAL COMPANY, LIMITED ,  NIPPON SODA CO., LTD. ,  NISSAN CHEMICAL INDUSTRIES LTD. ,  TOSOH CORPORATION

    发明人： KOBAYASHI, Yoichi ,  OMORI, Muneki ,  YAMADA, Chikako

    IPC分类号： C12N9/72 ,  C12N15/00 ,  C12N1/20 ,  C12P21/02 ,  A61K37/465

    CPC分类号： C12N9/6462 ,  C12Y304/21073

    摘要： A human prourokinase-like polypeptide having an amino acid sequence represented by the following formula: (Met).Ser1-X156.Y157.Z158- (wherein Met represents an optionally existing methionine, Ser represents serine present at 1-position of the N-terminal, X represents arginine or other amino acid present at 156-position, Y represents proline, glycine, alanine or valine present at 157-position, Z represents lysine or arginine present at 158-position, and the solid line represents the same amino acid sequence as that of corresponding part of natural human prourokinase or human urokinase-like polypeptide wherein lysine at 135-position is replaced by other amino acid than basic amino acids) or having an amino acid sequence substantially the same as this is disclosed. In addition, a DNA segment which codes the above-described polypeptide; a plasmid containing said DNA segment; E. coli transformed by said plasmid; a process for preparing said polypeptide by culturing said E. coli; a medicine containing said polypeptide; use of said polypeptide for prophylaxis or treatment for formation of thrombus; and use of said polypeptide for preparing the medicine for the above purpose are also disclosed.

    Polyester type polyfunctional macromonomer, gel and drug release controlling material responsive to changes in temperature
    78.
    发明公开
    Polyester type polyfunctional macromonomer, gel and drug release controlling material responsive to changes in temperature 失效
    多官能大分子单体的聚酯凝胶，并用依赖于温度波动递送活性成分的物质。

    公开(公告)号：EP0556818A1

    公开(公告)日：1993-08-25

    申请号：EP93102542.3

    申请日：1993-02-18

    申请人： SAGAMI CHEMICAL RESEARCH CENTER

    发明人： Nagase, Yu ,  Aoyagi, Takao ,  Miyata, Fusae

    IPC分类号： C08G63/08 ,  A61K47/34

    CPC分类号： C08G63/08 ,  A61K47/34

    摘要： A polyester type polyfunctional macromonomer represented by the general formula (I):

    wherein R¹ represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms, X represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having from 1 to 6 carbon atoms or a phenyl group, A represents an aliphatic polyester chain, m is 0 or 1, and p, which may be the same or different in each branched chains, represents an integer of from 0 to 6; a polyester type gel which is obtained by polymerization of the polyester type polyfunctional macromonomer; and a drug release controlling material responsive to changes in temperature comprising the polyester type gel are disclosed. The polyester type gel possesses mechanical properties suitable to various utilities, in particular, as a biodegradable polymeric material having a high tensile elongation. The drug release controlling material has an on-off control function of drug release responsive to changes in temperature depending upon the gel transition of the aliphatic polyester type gel.

    摘要翻译： 由通式（I）表示的聚酯类的多官能大分子单体：其中，R <1>表示氢原子或烷基具有1至6个碳原子基团，X表示氢原子，卤原子，氰基 基烷基具有1至6个碳原子或苯基，A darstellt到脂肪族聚酯链，m是0或1，且p，这可能是在每个支链的相同或不同的，darstellt到的从整数组 0至6; 聚酯类凝胶所有这是由聚酯型大分子单体的多官能的聚合而得到; 以及响应于温度，包括聚酯类凝胶的变化的药物释放控制材料是游离缺失盘。 聚酯类凝胶具有适合于各种用途的机械性能，特别是，作为具有高的拉伸伸长率的可生物降解的聚合物材料。 该药物释放控制材料具有药物释放响应于温度，这取决于脂肪族聚酯类凝胶的凝胶转变的变化的开 - 关控制功能。