公开(公告)号：EP2865078A1

公开(公告)日：2015-04-29

申请号：EP12735978.4

申请日：2012-06-26

申请人： Nissan Motor Company, Limited ,  Wisconsin Alumni Research Foundation

发明人： KATO, Takashi ,  LORENZ, Robert ,  LIMSUWAN, Natee

IPC分类号： H02K1/27 ,  H02P21/14

CPC分类号： H02K1/276 ,  H02P21/0085 ,  H02P21/141

摘要： A rotary electric machine includes a stator and a rotor. The rotor has at least one permanent magnet arranged in a d-axis magnetic path. The rotor includes a magnetic gap part located between the permanent magnet arranged in the d-axis magnetic path of one pole and an adjacent magnet with a different polarity, such that a d-axis magnetic flux forms a d-axis bypass passing through an area other than the permanent magnet. The d-axis bypass provides a magnetic resistance in a d-axis direction that is set below a magnetic resistance in a q-axis direction that is orthogonal to the d-axis resistance.

公开(公告)号：EP2839277A2

公开(公告)日：2015-02-25

申请号：EP13701877.6

申请日：2013-01-07

申请人： Wisconsin Alumni Research Foundation

发明人： EGHBALNIA, Hamid, R. ,  COOK, Mark ,  PORTER, Warren, Paul ,  BUTZ, Daniel, Elmer

IPC分类号： G01N33/497 ,  A61B5/00

CPC分类号： G01N33/497 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/412 ,  A61B5/4842 ,  A61B5/4845 ,  G06F19/00

摘要： The methods described herein are based on the observation that oscillations in breath isotope ratio data can be used for the purpose of identifying an "unhealthy" state in an organism such as a human. Described herein are methods of determining the state of health of an individual, such as the transition from healthy to infected, by identifying changes in oscillation modes in breath isotope ratio data. Changes in the frequency and/or amplitude of the oscillation modes are correlated with the heath of the individual. The methods can advantageously be used to provide information about the health of an individual in shorter periods of time than previous methods.

公开(公告)号：EP2814472A1

公开(公告)日：2014-12-24

申请号：EP13749206.2

申请日：2013-02-15

申请人： Wisconsin Alumni Research Foundation

发明人： RAINES, Ronald, Thaddeus ,  LUKESH, John

IPC分类号： A61K31/095

CPC分类号： C07K1/113 ,  C07B2200/07 ,  C07C323/25 ,  C07C327/06 ,  C07C329/16 ,  C07D339/08 ,  C07K1/1133 ,  C12N9/96

摘要： Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention can be employed to regulate protein function in proteins in which a sulfhydryl group is associated with biological activity. Reducing agents of this invention can prevent inactivation of a given protein or enhance activation of a given protein or other biological molecule in vitro and/or in vivo. Reducing agents of this invention can prevent or reduce oxidation of cysteine residues in proteins and prevent the formation of reduced activity protein dimers (or other oligomers). Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents.

摘要翻译： 用于还原二硫键的二硫代胺还原剂。 例如，本发明的还原剂可用于减少二硫键，特别是在蛋白质中，或防止形成二硫键，特别是在蛋白质和其他生物分子中。 本发明的还原剂可用于调节巯基与生物活性相关的蛋白质功能。 本发明的还原剂可防止给定蛋白质的失活或在体外和/或体内增强给定蛋白质或其他生物分子的活化。 本发明的还原剂可防止或减少蛋白质中半胱氨酸残基的氧化，并防止还原活性蛋白质二聚体（或其他寡聚体）的形成。 本发明的还原剂适用于各种生物应用，特别是作为研究和合成试剂。

公开(公告)号：EP2313368B1

公开(公告)日：2014-09-17

申请号：EP09790206.8

申请日：2009-07-09

申请人： Wisconsin Alumni Research Foundation

发明人： DELUCA, Hector, F. ,  TADI, Bulli, Padmaja ,  PLUM, Lori, A. ,  CLAGETT-DAME, Margaret

IPC分类号： C07C401/00 ,  A61K31/593 ,  A61P3/04 ,  A61P17/00 ,  A61P17/06 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02

CPC分类号： C07C401/00 ,  C07C2601/14 ,  C07C2602/24

公开(公告)号：EP2768804A1

公开(公告)日：2014-08-27

申请号：EP12781531.4

申请日：2012-10-11

申请人： Wisconsin Alumni Research Foundation

发明人： DELUCA, Hector, F. ,  PLUM, Lori, A. ,  SICINSKI, Rafal, R. ,  SIBILSKA, Izabela

IPC分类号： C07C401/00

CPC分类号： C07C401/00 ,  C07C2601/14 ,  C07C2602/24 ,  C07F7/1856

摘要： This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-1α,25 -dihydroxy-2-methylene-vitamin D3 as well as (5E)-(20S)-1α,25-dihydroxy-2 -methylene-vitamin D3 and (20R)-1α,25-dihydroxy-2-methylene-vitamin D3, as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also have relatively high calcemic activities evidencing use in the treatment of bone diseases.

摘要翻译： 本发明公开了2-亚甲基维生素D类似物，特别是（20S）-1α，25-二羟基-2-亚甲基维生素D3以及（5E） - （20S）-1α，25-二羟基-2-亚甲基 - 维生素D3和（20R）-1α，25-二羟基-2-亚甲基维生素D3，以及其用途。 这些化合物在阻止未分化细胞的增殖并诱导其分化为单核细胞方面表现出相对高的结合活性和显着的活性，从而证明其用作抗癌剂，特别是用于治疗或预防骨肉瘤，白血病，结肠癌，乳腺癌， 皮肤癌或前列腺癌。 这些化合物还具有相对较高的钙血活性，其用于治疗骨疾病。

公开(公告)号：EP2768803A1

公开(公告)日：2014-08-27

申请号：EP12778892.5

申请日：2012-10-09

申请人： Wisconsin Alumni Research Foundation

发明人： DELUCA, Hector, F. ,  PLUM, Lori, A. ,  SICINSKI, Rafal, R. ,  SIBILSKA, Izabela

IPC分类号： C07C401/00 ,  A61K31/59

CPC分类号： C07C401/00 ,  C07C35/18 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/24 ,  C07F7/1864

摘要： This invention discloses 2-methylene- vitamin D analogs of formula ( I) (wherein R and X are as defined in claim 1 ), and specifically (20S)-25- hydroxy-2-methylene- vitamin D3 and (20R)-25-hydroxy-2-mcthylene-vitamin D3, as well as pharmaceutical uses therefor, These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti¬ cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also have relatively high calcemic activities evidencing USC in the treatment of bone diseases. Formula (I).

摘要翻译： 本发明公开了2-亚甲基 - 维生素D类似物，特别是（20S）-25-羟基-2-亚甲基维生素D3和（20R）-25-羟基-2-亚甲基维生素D3及其药物用途。 这些化合物在阻止未分化细胞的增殖并诱导其分化为单核细胞方面表现出相对高的结合活性和显着的活性，从而证明其用作抗癌剂，特别是用于治疗或预防骨肉瘤，白血病，结肠癌，乳腺癌， 皮肤癌或前列腺癌。 这些化合物还具有相对较高的钙血活性，其用于治疗骨疾病。

公开(公告)号：EP2746252A1

公开(公告)日：2014-06-25

申请号：EP12199224.2

申请日：2012-12-21

申请人： Wisconsin Alumni Research Foundation (WARF)

发明人： DeLuca, Hector F. ,  Barycki, Rafal ,  Thoden, James B. ,  Holden, Hazel M.

IPC分类号： C07C401/00

CPC分类号： C07C401/00 ,  C07B2200/13 ,  C07C2601/14 ,  C07C2602/24

摘要： A method of purifying 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol to obtain 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol in crystalline form using precipitation with hexane from ethyl acetate. A method of preparing 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol crystals acceptable for X-ray experiment using precipitation with hexane from benzene by diffusive exchange of the solvents is also described.

摘要翻译： 一种纯化1± - 羟基-2-亚甲基-18,19-二氢 - 孕代孕甾醇的方法，用己烷从乙酸乙酯沉淀得到结晶形式的1± - 羟基-2-亚甲基-18,19-二氢 - 孕代孕酸钙。 还描述了通过溶剂的扩散交换制备用苯与己烷一起沉淀的X射线实验可接受的1± - 羟基-2-亚甲基-18,19-二氢 - 均二孕烯雌酚晶体的方法。

公开(公告)号：EP2010557B1

公开(公告)日：2014-02-26

申请号：EP07754132.4

申请日：2007-03-29

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： KAWAOKA, Yoshihiro ,  HORIMOTO, Taisuke ,  MURAKAMI, Shin

IPC分类号： C07K14/11

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/525 ,  A61K2039/5254 ,  C07K14/005 ,  C12N9/2402 ,  C12N15/85 ,  C12N2760/16051 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2800/107 ,  C12Y302/01018

摘要： The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes at least five internal genes from an influenza virus isolate that replicates to high titers in embryonated chicken eggs or MDCK cells.

公开(公告)号：EP2591769A3

公开(公告)日：2013-09-11

申请号：EP13152072.8

申请日：2007-12-31

申请人： Wisconsin Alumni Research Foundation

发明人： Clagett-Dame, Margaret ,  Deluca, Hector, F. ,  Nieves, Nirca, J. ,  Plum, Lori, A ,  Kaiser, Mary, E ,  Barycki, Rafal

IPC分类号： A61K9/08 ,  A61K47/10 ,  A61K31/59 ,  A61P17/06 ,  A61P17/10 ,  A61P17/00 ,  A61P35/00 ,  A61K8/67 ,  A61Q19/08 ,  A61Q19/00 ,  A61K9/48 ,  A61K47/44 ,  A61K31/203

CPC分类号： A61K31/59 ,  A61K8/67 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0095 ,  A61K31/203 ,  A61K47/10 ,  A61K47/44 ,  A61K2800/92 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/08

摘要： Topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin D analogs as active pharmaceutical ingredients include 19-nor-26,27-dimethylene-20(S)-2-methylene-1α,25-dihydroxyvitamin D3, 2-methylene-1α,25-dihydroxy-(17E)-17(20)-dehydro-19-nor vitamin D3, 2-methylene-(20R,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, 2-methylene-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnancalciferol, (2-(3'hydroxypropyl-1',2'-idene)-19,23,24-trinor-(20S)-1α-hydroxyvitamin D3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and/or a solute thereof.

摘要翻译： 局部药物组合物，试剂盒及其用于治疗各种皮肤病包括痤疮，银屑病，鱼鳞病，光老化，光损伤的皮肤，以及皮肤癌的治疗方法。 示例性的维生素D类似物作为活性药物成分包括19-去甲-26,27-二亚甲基 - 20（S）-2-亚甲基 - 1±，25-二羟基维生素D3，2-亚甲基-1-±，25-二羟基 - （17E） -17（20） - 脱氢-19-降维生素D3，2-亚甲基 - （20R，25S）-19.26-DINOR-1±，25-二羟基维生素D3，2-亚甲基23,23二氟-1-± 羟基-19-去甲bishomopregnacalciferol，2-亚甲基 - （20S）-23.23二氟-1-羟基±-19-去 - bishomopregnancalciferol，（2-（3'hydroxypropyl-1”，2'-偏二） -19,23,24 - 三去甲（20S）-1-羟基±D3，其立体异构体，在口腔组合物或其前体药物，或其盐，和/或它们的溶质。

公开(公告)号：EP2618680A1

公开(公告)日：2013-07-31

申请号：EP11761582.3

申请日：2011-09-26

申请人： Givaudan SA ,  Utah State University ,  Wisconsin Alumni Research Foundation

发明人： BHOWMIK, Tarun ,  BROADBENT, Jeff ,  WELKER, Dennis ,  STEELE, James ,  BUDINICH, Mateo

IPC分类号： A23L1/00 ,  C12N5/00 ,  C12N9/16 ,  C12N15/00

CPC分类号： C12N9/16 ,  A23C19/0328 ,  A23L27/25 ,  C12P11/00 ,  C12Y301/02 ,  G01N2333/916

摘要： Disclosed are nucleotide sequences encoding thioesterase enzymes, methods for their production, their use in methods to form thioesters, and their use in methods of screening for other wild type bacteria capable of producing said thioesterase enzymes. Also disclosed are compositions comprising thioesters produced by the methods disclosed herein.