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公开(公告)号：EP1828176A1
公开(公告)日：2007-09-05
申请号：EP05854098.0
申请日：2005-12-15
IPC分类号： C07D413/06 , C07D401/06 , C07D451/02 , C07D451/06 , A61K31/4709 , A61K31/538 , A61P25/28 , A61P25/18
CPC分类号： C07D413/06 , C07D401/04 , C07D401/06 , C07D417/06 , C07D451/02 , C07D451/04 , C07D451/06
摘要： The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
摘要翻译： 本发明涉及作为毒蕈碱受体激动剂的四氢喹啉化合物; 包含其的组合物; 用所述化合物抑制毒蕈碱受体活性的方法; 使用所述化合物治疗与毒蕈碱受体相关的疾病状况的方法; 以及使用所述化合物鉴定适于治疗的受试者的方法。
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公开(公告)号：EP1812798A2
公开(公告)日：2007-08-01
申请号：EP05824685.1
申请日：2005-11-18
发明人： PIU, Fabrice
CPC分类号： G01N33/6875 , G01N33/502 , G01N33/74 , G01N33/78 , G01N2500/00 , G01N2500/04 , G01N2500/10
摘要： A method and kit developed to identify substances that act as ligands, corepressors, coactivators, agonist and antagonists for cloned nuclear hormone receptors, as well as a test kit for use in the methods is provided herein. More specifically, the method involves expressing a nuclear hormone receptor, receptor heterodimer, and/or receptor homodimer, DNA encoding one or more signaling molecules and DNA encoding a marker, incubating the cells with a test substance, and identifying whether the test substance interacts with the receptor quantitatively or qualitatively by identifying the amount of marker and/or the proliferation of the cells.
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73.发明公开USE OF N-DESMETHYLCLOZAPINE TO TREAT HUMAN NEUROPSYCHIATRIC DISEASE 审中-公开N-去甲基氯氮平对人类NEURO精神疾病的治疗中的用途
公开(公告)号：EP1778244A1
公开(公告)日：2007-05-02
申请号：EP05802835.8
申请日：2005-08-04
发明人： WEINER, David M. , BRANN, Mark R.
CPC分类号： A61K31/5513
摘要： Disclosed herein is a method to treat neuropsychiatric diseases including psychosis, affective disorders, dementia, neuropathic pain, and glaucoma. Treatment is carried out by administering a therapeutically effective amount of N-desmethylclozapine to a patient suffering from a neuropsychiatric disease.
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74.发明公开SELECTIVE SEROTONIN RECEPTOR INVERSE AGONISTS AS THERAPEUTICS FOR DISEASE 审中-公开选择性血清素受体反向激动剂治疗剂预防疾病
公开(公告)号：EP1750705A1
公开(公告)日：2007-02-14
申请号：EP05753034.7
申请日：2005-05-20
IPC分类号： A61K31/445 , A61K31/4468 , A61K31/138 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00
CPC分类号： A61K31/138 , A61K9/0019 , A61K31/445 , A61K31/4468 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising an inverse serotonin receptor agonist or a serotonin receptor antagonist and an anti-psychotic agent. Disclosed herein are also methods of treating psychotic disorders using the disclosed pharmaceutical compositions.
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75.发明公开USE OF THE LIPOXIN RECEPTOR, FPRL1, AS A TOOL FOR IDENTIFYING COMPOUNDS EFFECTIVE IN THE TREATMENT OF PAIN AND INFLAMMATION 审中-公开使用本LIPOXINREZEPTORS FPRL1作为标识的疼痛和炎症的活性化合物的治疗手段
公开(公告)号：EP1692502A2
公开(公告)日：2006-08-23
申请号：EP04810415.2
申请日：2004-11-04
IPC分类号： G01N33/50
CPC分类号： C07D295/185 , C04B35/632 , C07D209/20 , C07D233/88 , C07D249/10 , C07D401/12 , C07D405/12 , G01N2333/726
摘要： Disclosed herein are compounds that selectively activate the FPRL1 receptor. Further disclosed are methods of alleviating inflammatory responses by regulating key steps in leukocyte trafficking and preventing neutrophil-mediated tissue damage by administering to a subject a therapeutically effective amount of the compounds disclosed herein. In addition, methods of modulating, or specifically agonizing, the FPRL1 receptor by administering an effective amount of the compounds disclosed herein are provided.
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76.发明公开
公开(公告)号：EP1589974A2
公开(公告)日：2005-11-02
申请号：EP04704073.8
申请日：2004-01-21
发明人： WEINER, David, M. , BRANN, Mark, R.
CPC分类号： A61K31/5513
摘要： Disclosed herein is a method to treat neuropsychiatric diseases including psychosis, affective disorders, dementia, neuropathic pain, and glaucoma. Treatment is carried out by administering a therapeutically effective amount of N-desmethylclozapine to a patient suffering from a neuropsychiatric disease.
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公开(公告)号：EP1278741A1
公开(公告)日：2003-01-29
申请号：EP01932682.6
申请日：2001-04-27
发明人： ANDERSSON, Carl-Magnus, A. , FRIBERG, Bo, Lennart, M. , SKJAERBAEK, Niels , SPALDING, Tracy , ULDAM, Allan, K.
IPC分类号： C07D401/06 , C07D413/06 , C07D405/06 , C07D417/06 , C07D409/06 , A61K31/454 , A61P25/28 , A61P27/06 , A61P25/18 , A61P25/04 , C07D471/04
CPC分类号： C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/04 , C07D473/00 , C07D487/04
摘要： Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial effect. In the method, an effective amount of a compound is administered to a patient in need of such treatment.
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78.发明授权IDENTIFICATION OF LIGANDS BY SELECTIVE AMPLIFICATION OF CELLS TRANSFECTED WITH RECEPTORS 失效IDENTIFYING配体通过择一再生，BY受体TRANZFIZIERTEN细胞
公开(公告)号：EP0708922B1
公开(公告)日：1999-03-10
申请号：EP94923478.5
申请日：1994-07-13
发明人： Brann, Mark Robert
IPC分类号： G01N33/566 , C12Q1/68 , C07K14/705
CPC分类号： G01N33/5041 , C07K14/70571 , C12Q1/6811 , C12Q1/6897 , C12Q2334/10 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/566 , G01N33/581 , G01N33/74 , G01N2333/48 , G01N2333/70571 , G01N2500/10
摘要： A method of detecting a substance capable of acting as a ligand, the method comprising: (a) incubating, under conditions permitting cell amplification, cells transfected with DNA coding for a receptor capable of influencing cell amplification in response to a ligand, the cells comprising a marker of cell amplification, with a test substance which is a potential agonist or antagonist of the receptor, and (b) after a period of time sufficient to permit cell amplification, determining the presence or absence of amplification of cells containing the marker relative to cells not containing the marker.
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