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    Diagnosis of a disease and monitoring of therapy using the AC133 gene
    73.
    发明公开
    Diagnosis of a disease and monitoring of therapy using the AC133 gene 审中-公开
    诊断von Krankheiten undÜberwachungeiner Therapie unter Verwendung des AC133 Gens

    公开(公告)号：EP1571225A1

    公开(公告)日：2005-09-07

    申请号：EP04075686.8

    申请日：2004-03-02

    申请人： PrimaGen Holding B.V. ,  UMC Utrecht Holding B.V.

    发明人： Penning, Maarten Tjerk ,  Beerepoot, Laurens Victor ,  van den Broek, Sebastiaan Johannes Jacobus ,  Mehra, Niven ,  Voest, Emile Eugene

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/142 ,  C12Q2600/158

    摘要： The invention provides a method for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from said individual comprises an expression product of AC133 in an amount that is indicative for said disease or for the treatment thereof. Said amount is preferably quantified and compared with a reference value. In one aspect said amount is compared with an amount of said expression product present in a sample that was obtained from said individual before said treatment. A use of a nucleic acid molecule comprising at least part of a sequence of AC133 or an analogue thereof for monitoring a treatment of an individual suffering from a disease is also provided, as well as a diagnostic kit comprising such nucleic acid molecule.

    摘要翻译： 本发明提供了一种用于分类患有或有风险患有疾病的个体的样品的方法，以及用于监测患有疾病的个体的治疗的方法，包括确定来自所述个体的样品是否包含 AC133，其量表示所述疾病或用于治疗。 所述量优选地定量并与参考值进行比较。 在一个方面，将所述量与在所述处理之前从所述个体获得的样品中存在的所述表达产物的量进行比较。 还提供了包含至少部分AC133序列的核酸分子或其类似物用于监测患有疾病的个体的治疗的用途，以及包含该核酸分子的诊断试剂盒。

    Selective MR imaging of magnetic susceptibility deviations
    75.
    发明公开
    Selective MR imaging of magnetic susceptibility deviations 审中-公开
    on t t t t t t t t t t t t t t t

    公开(公告)号：EP1471362A1

    公开(公告)日：2004-10-27

    申请号：EP03076199.3

    申请日：2003-04-24

    申请人： Universiteit Utrecht Holding B.V. ,  UMC Utrecht Holding B.V.

    发明人： Seppenwoolde, Jan Hendrik ,  Bakker, Christianus Johannes Gerardus

    IPC分类号： G01R33/28

    CPC分类号： G01R33/286

    摘要： Method for magnetic resonance imaging (MRI) of at least one specific element, wherein signal of background tissue represented in an MR image is at least partially dephased by applying a gradient imbalance or additional gradient, wherein signal around said element is accordingly conserved, resulting in a selective depiction of said element.

    摘要翻译： 通过应用梯度不平衡或附加梯度，在MR图像中表示的背景组织的信号被部分解相。 元件周围的信号相应地被保存，导致元素的选择性描绘。 还包括以下独立权利要求：（a）用于被动跟踪包括抗磁性，顺磁性或铁磁性元件的装置的方法; （b）使用MRI中的去相信号，特别是器件跟踪，用于MRI的图像中的特定元素的正对比的选择性描绘; （c）增强MRI装置上MR图像对比度的方法; 和（d）MRI装置。