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103 条记录 (耗时 0.018 秒)

    3-BENZOYLINDOLE DERIVATIVES AND DRUGS CONTAINING THE SAME
    73.
    发明公开
    3-BENZOYLINDOLE DERIVATIVES AND DRUGS CONTAINING THE SAME 失效
    3-BENZOYLINDOL-DERIVATE UND SIE ENTHALTENDE MEDIKAMENTE

    公开(公告)号：EP0997457A1

    公开(公告)日：2000-05-03

    申请号：EP98932523.8

    申请日：1998-07-15

    申请人： ZERIA PHARMACEUTICAL CO., LTD.

    发明人： SATO, Hiroki, Zeria Pharmaceutical Co., Ltd. ,  TAKEI, Mineo, Zeria Pharmaceutical Co., Ltd. ,  CHIKAZAWA, Jun, Zeria Pharmaceutical Co., Ltd. ,  FUKUDA, Yoichi, Zeria Pharmaceutical Co., Ltd. ,  NAGANO, Eiichi, Zeria Pharmaceutical Co., Ltd.

    IPC分类号： C07D209/12 ,  A61K31/495

    CPC分类号： C07D209/12

    摘要： The present invention is directed to 3-benzoylindole derivatives represented by the following formula (I):
    (wherein R 1 represents a lower alkyl group, n is an integer from 1 to 5; each of R 2 and R 3 represents a hydrogen atom, a lower alkyl group, or an optionally substituted phenyl group; and R 4 represents a hydrogen atom, a lower alkyl group, or a benzyl group) and to a pharmaceutical containing the same. This compound is endowed with strong α 1 -adrenergic receptor blocking action and strong testosterone 5α-reductase inhibitory action, as well as high level of safety, and thus is useful as an excellent preventive or therapeutic drug for prostatic hypertrophy or accompanying urination disorder, alopecia, and acne.

    摘要翻译： 本发明涉及由下式（I）表示的3-苯并吲哚衍生物：其中R 1表示低级烷基，n为1〜5的整数，R 2和 R 3表示氢原子，低级烷基或任选取代的苯基; R 4表示氢原子，低级烷基或苄基）和含有该烷基的药物。 该化合物具有强α1-肾上腺素能受体阻断作用和强烈的睾酮5α-还原酶抑制作用，并具有高水平的安全性，因此可用作前列腺肥大或伴随排尿障碍的优良预防或治疗药物， 秃发和痤疮。

    INDOLEACETIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING SAME AS ACTIVE INGREDIENTS
    77.
    发明公开
    INDOLEACETIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING SAME AS ACTIVE INGREDIENTS 失效
    印度酸衍生物，其制备方法和含有作为活性成分的药物

    公开(公告)号：EP0382854A4

    公开(公告)日：1991-11-13

    申请号：EP89907824

    申请日：1989-07-04

    申请人： ZERIA PHARMACEUTICAL CO., LTD.

    发明人： ARAI, HEIHACHIRO C/O ZERIA PHARM. CO.LTD. CENTR. ,  UEDA, IKUO

    IPC分类号： C07D209/28 ,  C07D403/12 ,  A61K31/405

    CPC分类号： C07D403/12 ,  C07D209/28

    摘要： The invention relates to indoleacetic acid derivatives represented by general formula (I), [wherein X represents a piperidino group, a 1-pyrrolidinyl group or a 3-hydroxy-1-pyrrolidinyl group, Y represents α, (wherein R1 represents a hydrogen atom or a lower alkyl group, and $(1,3)$ represents 0, 1 or 2) or β, (wherein R2 represents a hydrogen atom, a lower akyl group or a hydroxy group, m represents 0, 1 or 2, and n represents 1, 2 or 3)] and their salts, and antiinflammatory agents, antirheumatic agents and antiulcer agents containing them as active ingredients. The compounds possess a strong antiinflammatory action while causing extremely reduced troubles of digestive organs which is a serious defect with conventional non-steroidal antiinflammatory agents, and possess an excellent antiulcer action as well.