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71.发明公开Use of milk for the manufacture of a hyperimmune milk composition for treating disorders of the pulmonary system in mammals 失效用于生产超免疫乳化合物用于在哺乳动物中的呼吸系统疾病的治疗使用的牛奶。
公开(公告)号：EP0380032A1
公开(公告)日：1990-08-01
申请号：EP90101230.2
申请日：1984-10-26
IPC分类号： A61K35/20 , A61K39/395 , A23C9/20 , A23C9/123 , A24B15/30
CPC分类号： A61K39/39508 , A23C9/20 , A23L33/10 , A23V2002/00 , A24B15/30 , A61K35/20 , C07K2317/11 , A23V2200/324 , A23V2250/5424
摘要： Use of hyperimmune milk for treating pulmonary disorders associated with smoking in mammals which comprises: administering to the mammal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or sparing effects on lung tissue.
摘要翻译： 用于治疗与吸烟哺乳动物，其包括相关的肺疾病使用的超免疫乳：管理从牛科动物中收集的哺乳动物奶被保持在一个超免疫状态，在量和足够长的时间，以产生抗动脉硬化或节约对肺组织的影响 ，
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公开(公告)号：EP0336694A2
公开(公告)日：1989-10-11
申请号：EP89303294.6
申请日：1989-04-04
发明人： Beck, Lee R.
IPC分类号： A61K35/20
CPC分类号： A23C9/20 , A24B15/30 , A61K35/20 , A61K39/39508 , C07K2317/11
摘要： An anti-inflammatory factor can be isolated from milk collected from a milk-producing animal. The factor may be isolated from milk is produced by a milk-producing animal maintained in a hyperimmunized state.
摘要翻译： 可以从产奶动物收集的牛奶中分离抗炎因子。 该因子可以从保持在超免疫状态的产奶动物产生的乳中分离出来。
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公开(公告)号：EP0129418A3
公开(公告)日：1986-05-07
申请号：EP84304038
申请日：1984-06-15
申请人： GLAXO GROUP LIMITED
发明人： Lucas, Alan , Barr, Richard Ian
IPC分类号： A23C11/04 , A23C09/158
CPC分类号： A23C11/04 , A23C9/158 , A23C9/20 , Y10S426/801
摘要： Infant foods suitable for use in the feeding of low birthweight infants, more especially preterm infants, are disclosed. The foods contain a relatively high level of vitamin B 2 and may be prepared so as to have an opacity greater than that of human breast milk leading to less susceptibility of the vitamin B 2 to breakdown by UV-light when used for the feeding of low birthweight infants who are receiving phototherapy. Preferred infantfoods according to the invention also have high contents of vitamin B 6 , vitamin C, vitamin D, vitamin E, folic acid, copper and zinc whilst containing no added iron. Another aspect of the invention isthe inclusion oftaurine and carnitine. One unexpacted property of the infantfoods according to the invention with high vitamin content is that their use has been found to reduce the incidence of hyperbilirubinaemia in low birthweight infants.
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74.发明公开Use of hyperimmune milk for the manufacture of a medicament for the treatment of cardio-vascular diseases or for lowering lipid bloodstream levels 失效使用的超免疫乳用于血脂值的心血管疾病和Verringung的治疗的药物中的用途。
公开(公告)号：EP0143345A2
公开(公告)日：1985-06-05
申请号：EP84112946.3
申请日：1984-10-26
发明人： Stolle, Ralph J. , Beck, Lee R Dr.
IPC分类号： A61K35/20 , A61K39/395 , A23C9/20 , A23C9/123 , A24B15/30
CPC分类号： A61K39/39508 , A23C9/20 , A23L33/10 , A23V2002/00 , A24B15/30 , A61K35/20 , C07K2317/11 , A23V2200/324 , A23V2250/5424
摘要： Use of hyperimmune milk for treating vascular disorders or pulmonary disorders associated with smoking in mammals which comprises: administering to the mammal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.
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公开(公告)号：EP4423241A1
公开(公告)日：2024-09-04
申请号：EP22812548.0
申请日：2022-10-27
发明人： HALLER, Corinne , CHAMBRIN, Brice , BIANCHI, Arianna , MASHINCHIAN, Omid , KRAUS, Marine , DESTAILLATS, Frederic , YART, Lucile
CPC分类号： C12N5/0631 , A23C9/206 , A23C9/20 , C12N2501/1120130101 , C12N2501/11920130101 , C12N2501/1220130101 , C12N2501/31520130101 , C12N2501/3320130101 , C12N2501/3720130101 , C12N2501/39220130101 , C12N2501/9120130101 , C12N2506/4520130101 , C12N2533/5020130101 , C12N2501/3920130101 , C12N2501/72720130101 , C12N2513/0020130101 , C12N2533/5420130101 , C12N2533/9020130101
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公开(公告)号：EP3179868B1
公开(公告)日：2018-10-31
申请号：EP15787042.9
申请日：2015-08-17
申请人： N.V. Nutricia
CPC分类号： A23L33/115 , A23C9/20 , A23C2240/05 , A23L33/40 , A23V2002/00 , A23V2250/18 , A23V2200/322 , A23V2250/184 , A23V2250/204
摘要： The present invention relates to a method for improving behaviour in a human subject, comprising administering a nutritional composition comprising 5-50 wt % vegetable lipids based on dry weight of the composition to the subject, the nutritional composition comprising lipid globules having (i) a volume-weighted mode diameter above 1.0 micrometer and/or (ii) a diameter of 2 to 12 micrometer in an amount of at least 45 volume % based on total lipid, wherein improving behaviour is selected from (a) increasing novel object recognition; (b) increasing the preference for novelty; (c) increasing the attention for surroundings; and (d) increasing exploratory behaviour and/or exploratory activity.
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77.发明公开
公开(公告)号：EP3216349A1
公开(公告)日：2017-09-13
申请号：EP17167341.1
申请日：2008-12-05
申请人： N.V. Nutricia
发明人： MINOR, Marcel , SLIWINSKI, Edward Lucian , HOTRUM, Natalie Elizabeth , KIERS, Wynette Hermina Agnes , VAN STEENIS, Suzanne , WATERINK, Arjan , DE KORT, Esther Jacqueline
CPC分类号： A23C9/20 , A23C9/1512 , A23L33/19 , A23L33/40 , A23V2002/00 , A23V2250/54246
摘要： Protein-dense micellar casein-based liquid enteral nutritional composition are provided that contain micellar casein and optionally caseinate. Liquid enteral nutritional compositions are disclosed comprising 10 to 20 g of protein per 100 ml of the composition, in which all or a major part of said protein comprises native micellar casein. Also, a method is disclosed for producing the composition according to the invention, comprising a step wherein an aqueous protein solution in which all or a major part of said protein comprises native micellar casein, is subjected to an evaporation step.
摘要翻译： 提供了蛋白质致密的基于胶束酪蛋白的液体肠内营养组合物，其含有胶束酪蛋白和任选的酪蛋白酸盐。 公开了液体肠内营养组合物，其包含每100ml组合物10至20g蛋白质，其中所有蛋白质或主要部分包含天然胶束酪蛋白。 此外，公开了一种制备根据本发明的组合物的方法，该方法包括将其中全部或大部分所述蛋白质包含天然胶束酪蛋白的蛋白质水溶液进行蒸发步骤的步骤。
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78.发明公开Hydrolases, nucleic acids encoding them and mehods for making and using them 有权水解酶，核酸编码它们和制备方法以及它们的使用
公开(公告)号：EP2853593A1
公开(公告)日：2015-04-01
申请号：EP14187967.6
申请日：2004-03-08
申请人： DSM IP Assets B.V.
CPC分类号： C12N9/20 , A23C9/20 , A23C19/05 , A23C19/063 , A23K10/14 , A23K20/189 , A23L29/06 , A23V2002/00 , A61K8/0216 , A61K8/375 , A61K8/606 , A61K8/66 , A61K38/465 , A61K2800/86 , A61Q5/06 , A61Q11/00 , A61Q19/00 , C10M129/70 , C10M129/76 , C10M2207/281 , C10M2207/289 , C10M2207/40 , C11C3/08 , C11D3/386 , C11D3/38627 , C11D3/38636 , C12C1/047 , C12C5/004 , C12C11/003 , C12N9/14 , C12N9/16 , C12N9/18 , C12P7/6418 , C12Q1/34 , C12Y301/01003 , D06M16/003 , D06M2200/12 , D06M2200/30 , D06M2200/50 , G01N33/573 , G01N2500/02
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the invention are used to synthesize enantiomerically pure chiral products.
摘要翻译： 本发明提供水解酶，多核苷酸编码它们，以及制备和使用这些多核苷酸和多肽的方法。 在一个方面，本发明涉及多肽，例如酶，其具有水解酶活性，例如，以酯酶，酰基转移酶，脂肪酶，磷脂酶（例如磷脂酶A，B，C和D活性，patatin启动活性，脂质酰基水解酶（ LAH）活性）或蛋白酶活性，包括热电表和耐热水解酶活性，和多核苷酸编码合成的酶，以及制备和使用这些多核苷酸和多肽。 所述多肽的本发明的水解酶活性和肽包括酯酶活性，脂肪酶活性（脂质的水解），酸解反应（在酯化脂肪酸以游离脂肪酸，以取代），酯交换反应（的甘油三酯之间脂肪酸交换） 酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。 本发明的多肽可以在多种药物，农业和工业环境中，包括化妆品和营养保健品的制造中的使用。 在另一个方面，本发明的多肽被用于合成对映异构体纯的手性产物。
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公开(公告)号：EP2414396B1
公开(公告)日：2015-02-25
申请号：EP10713013.0
申请日：2010-03-30
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2863 , A23C9/20 , A23C9/206 , A23C2230/10 , A61K39/39541 , A61K39/3955 , A61K2039/505 , C07K16/2878 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/92 , C07K2317/94
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公开(公告)号：EP2822568A1
公开(公告)日：2015-01-14
申请号：EP13757439.8
申请日：2013-03-11
发明人： FANNING, Aaron Calvin , PATEL, Hasmukh Ambalal , SCHALK, Johannes , HALL, Ramon Stafford , SCHWARZENBACH, Roger Richard , UKRAINTSEV, Sergey Yevgenievich
CPC分类号： A61K38/1709 , A23C9/142 , A23C9/1422 , A23C9/1427 , A23C9/146 , A23C9/20 , A23J1/20 , A23J1/202 , A23L2/66 , A23L33/19 , A23V2002/00 , A61K35/20 , A61K47/46 , A23V2250/54246
摘要： Casein compositions for increasing the rate of gastric emptying following ingestion of the composition, increasing the digestibility of a protein composition, or increasing the rate of delivery of amino acids to the blood, or for increasing the blood serum concentration of free leucine in a subject, preferably to substantially the same level as whey protein, the casein being about 10 to about 100% calcium depleted, having a degree of hydrolysis less than about 1% and having an unmodified phosphorylation pattern.
摘要翻译： 酪蛋白组合物，用于增加摄取组合物后胃排空速率，增加蛋白质组合物的消化率，或增加氨基酸递送到血液中的速率，或增加受试者中游离亮氨酸的血清浓度， 优选达到与乳清蛋白基本相同的水平，酪蛋白为约10至约100％的钙消耗，具有小于约1％的水解度并具有未修饰的磷酸化模式。
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