PEPTIDE FOR INDUCING MAST CELL-SPECIFIC APOPTOSIS AND USE THEREOF
    73.
    发明公开
    PEPTIDE FOR INDUCING MAST CELL-SPECIFIC APOPTOSIS AND USE THEREOF 审中-公开
    用于诱导肥大细胞特异性凋亡的肽及其用途

    公开(公告)号:EP2998313A1

    公开(公告)日:2016-03-23

    申请号:EP13884437.8

    申请日:2013-10-25

    申请人: Caregen Co., Ltd.

    IPC分类号: C07K7/08 A61K38/10 A61P37/08

    摘要: A peptide according to the present invention can perform a function identical or similar to the function of natural CTLA-4 and has an excellent degree of skin penetration due to a small size. The peptide according to the present invention effectively binds to antigen presenting cell surface proteins (CD80 and CD86) to inhibit activity of T cells and thus is capable of inhibiting the expression of inflammatory cytokines (for example, IL-2 and IFN-γ). As a result, a composition comprising the peptide according to the present invention exhibits excellent effects in terms of preventing, treating, or improving Th1-mediated immune diseases. Therefore, the superior activity and stability of the peptide according to the present invention can be useful when applied to medicine, quasi-drugs, and cosmetics.

    摘要翻译: 根据本发明的肽可以执行与天然CTLA-4的功能相同或相似的功能,并且由于小尺寸而具有优异的皮肤渗透程度。 根据本发明的肽有效地结合抗原呈递细胞表面蛋白(CD80和CD86)以抑制T细胞的活性,因此能够抑制炎性细胞因子(例如IL-2和IFN-γ)的表达。 结果,含有本发明肽的组合物在预防,治疗或改善Th1介导的免疫疾病方面表现出优异的效果。 因此,当应用于药物,准药物和化妆品时,根据本发明的肽的优异的活性和稳定性可以是有用的。