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公开(公告)号：EP2392559A1
公开(公告)日：2011-12-07
申请号：EP11177818.9
申请日：2008-05-08
申请人： Pharmacofore, Inc.
发明人： Jenkins, Thomas
IPC分类号： C07C39/06 , C07C39/27 , C07C271/44 , C07C37/00 , C07C37/05 , C07C37/055 , C07C37/68 , C07C37/84 , C07C245/20 , A61K9/00
CPC分类号： C07C39/06 , A61K9/0019 , C07B2200/07 , C07C37/003 , C07C37/045 , C07C37/055 , C07C37/86 , C07C39/27 , C07C245/20 , C07C271/44 , C07C39/19
摘要： A (+)-stereoisomer of formula (I), wherein X is H or F; or a salt thereof; which is useful: as an anesthetic; for inducing or maintaining general anesthesia; for promoting sedation; for promoting an antiemetic effect; for treatment of nausea or vomiting; or for treatment of a migraine.
摘要翻译： 式（I）的（+） - 立体异构体，其中X为H或F; 或其盐; 这是有用的：作为麻醉剂; 用于诱导或维持全身麻醉; 促进镇静; 用于促进止吐效果; 用于治疗恶心或呕吐; 或用于治疗偏头痛。
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72.发明公开
公开(公告)号：EP2382172A1
公开(公告)日：2011-11-02
申请号：EP09799106.1
申请日：2009-12-23
申请人： Novartis AG
IPC分类号： C07B53/00 , C07C37/00 , C07C213/08 , C07C269/06 , C07C39/11 , C07C271/44 , C07C215/50 , C07C309/64
CPC分类号： C07C269/04 , C07B2200/07 , C07C37/002 , C07C213/02 , C07C213/08 , C07C303/28 , C07C303/30 , C07C309/66 , C07C215/50 , C07C39/11
摘要： A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drag substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate.
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公开(公告)号：EP2321243A1
公开(公告)日：2011-05-18
申请号：EP08875897.4
申请日：2008-12-17
摘要： A process for preparing 2,2-bis(4-hydroxyphenyl)propane (p,p-bisphenol-A) from2,4,4-trimethyl-2-(4-hydroxyphenyl)chroman (chroman 1.5) is disclosed. Phenol andchroman 1.5 are contacted over an acidic ion exchange resin at a given temperature for agiven period of time. The process results in improved quality of p,p-bisphenol-A, betterperformance of catalyst, improved raw material usage, and reduced waste.
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公开(公告)号：EP2114846B1
公开(公告)日：2010-12-08
申请号：EP08716098.2
申请日：2008-02-28
申请人： DSM IP Assets B.V.
发明人： BREUNINGER, Manfred , JORAY, Marcel
CPC分类号： C07C45/64 , C07C37/002 , C07C39/11 , C07C45/46 , C07C45/80 , C07C45/81 , C07C49/825 , C07C49/82
摘要： Process for the preparation of hydroxytyrosol, characterized by reacting 4- chloroacetyl-catechol with a metal formate and formic acid in an aqueous solvent optionally containing a lower alkanol and catalytically hydrogenating the 4- hydroxyacetyl-catechol obtained in the presence of a precious metal, preferably on a carrier.
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75.发明授权
公开(公告)号：EP1771530B1
公开(公告)日：2009-09-09
申请号：EP05772822.2
申请日：2005-07-19
申请人： Polnox Corporation
发明人： CHOLLI, Ashok, L.
CPC分类号： C09K15/08 , C07C37/002 , C07C45/46 , C07C49/83 , C08F12/24 , C08F112/14 , C08G61/02 , C08G61/025 , C08G61/10 , C08G2261/1422 , C08G2261/1424 , C08G2261/1426 , C08G2261/148 , C08G2261/312 , C08G2261/3424 , C09K15/12 , C09K15/20 , C09K15/28 , C12P7/22 , C12P7/26 , C12P7/62 , C12P13/02 , Y02E60/324 , C07C39/16
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公开(公告)号：EP1654209B1
公开(公告)日：2008-11-12
申请号：EP04740380.3
申请日：2004-06-28
申请人： Unilever PLC , Unilever N.V.
发明人： BHAT, Ramachandra , DHANUKA, Vinodkumar, Ramniranjan , HARICHIAN, Bijan Unilever R & D Edgewater
CPC分类号： C07C37/002 , C07C39/08
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公开(公告)号：EP1654209A1
公开(公告)日：2006-05-10
申请号：EP04740380.3
申请日：2004-06-28
申请人： UNILEVER PLC , UNILEVER N.V.
发明人： BHAT, Ramachandra , DHANUKA, Vinodkumar, Ramniranjan , HARICHIAN, Bijan Unilever R & D Edgewater
CPC分类号： C07C37/002 , C07C39/08
摘要： A process for the preparation of a compound of formula (I) wherein R is a hydrogen or a C1-6 alkyl group which is straight chain, branched or cyclic, with or without an oxygen, nitrogen or sulphur heteroatom anywhere in the chain or ring by reacting a compound of formula (II) with a source of hydrogen selected from either hydrogen or water in the presence of a mixture of at least two catalysts selected from nickel, raney nickel, and palladium, at a pH below 7.0 in a solvent medium comprising an alcohol having a carbon chain length of up to 3.
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公开(公告)号：EP1535889A1
公开(公告)日：2005-06-01
申请号：EP03771263.5
申请日：2003-07-10
IPC分类号： C07B59/00 , C07C5/00 , C07C15/16 , C07C37/00 , C07C39/04 , C07C39/28 , C07C51/347 , C07C63/06 , C07C63/08 , C07C209/68 , C07C211/46 , C07C217/84 , C07C315/04 , C07C317/14
CPC分类号： C07C5/00 , C07B59/00 , C07B59/001 , C07B2200/05 , C07C37/00 , C07C51/00 , C07C51/347 , C07C209/68 , C07C315/04 , C07C63/08 , C07C63/06 , C07C317/14 , C07C211/46 , C07C211/51 , C07C39/04 , C07C39/28
摘要： The present invention relates to a method for deuteration of a compound having an aromatic ring, using an activated catalyst, and the method comprises reacting a compound having an aromatic ring with heavy hydrogen source in the presence of an activated catalyst selected from a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst.
摘要翻译： 本发明涉及一种使用活化催化剂氘代具有芳环的化合物的方法，该方法包括在活性催化剂存在下使具有芳环的化合物与重氢源反应，所述催化剂选自铂催化剂， 铑催化剂，钌催化剂，镍催化剂和钴催化剂。
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80.发明公开CATALYTIC OXIDATION OF ORGANIC SUBSTRATES BY TRANSITION METAL COMPLEXES IN ORGANIC SOLVENT MEDIA EXPANDED BY SUPERCRITICAL OR SUBCRITICAL CARBON DIOXIDE 有权有机底使用有机溶剂，用超或亚临界二氧化碳的过渡金属络合物催化氧化正在扩大
公开(公告)号：EP1268383A1
公开(公告)日：2003-01-02
申请号：EP01928364.7
申请日：2001-04-03
IPC分类号： C07C45/00 , C07C49/105 , C07C41/00 , C07C37/00 , C07C27/00 , C07C29/03 , C07C67/00 , C07B41/04 , C07B41/02 , C08F2/46
CPC分类号： C07D303/04 , C07B41/00 , C07C27/12 , C07C29/50 , C07C45/34 , C07C46/08 , C07C2601/14 , C07C2601/16 , C07D301/06 , Y02P20/544 , C07C49/713 , C07C49/603 , C07C35/14 , C07C35/18
摘要： Improved oxidation methods are provided wherein a reaction mixture comprising a substrate to be oxidized (e.g., phenols, alkenes) and an oxidation catalyst (typically dispersed in an organic solvent system) is supplemented with a compressed gas which expands the reaction mixture, thus accelerating the oxidation reaction. In preferred practice pressurized subcritical or supercritical carbon dioxide is used as the expanding gas, which is introduced into the reaction mixture together with an oxidizing agent. The inventive methods improve the substrate conversion and product selectivity by increasing the solubility of the oxidizing agent in the reaction mixture.
摘要翻译： 提供worin改进的氧化方法的反应混合物，其包含一个基板被氧化（例如，苯酚，烯烃）和氧化催化剂（典型地分散在有机溶剂系统）补充有，扩大了反应混合物，从而加速了压缩气体 氧化反应。 在优选实践中加压亚临界或超临界二氧化碳作为膨胀气体，所有这些被引入到反应混合物中连同在氧化剂。 本发明的方法提高由在反应混合物中提高氧化剂的溶解度的基片的转化率和产物选择性。
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