公开(公告)号：EP2725004B1

公开(公告)日：2018-02-28

申请号：EP12802693.7

申请日：2012-06-21

申请人： Kaneka Corporation

发明人： KAWACHI Hideo ,  KITAMURA Shiro ,  UEDA Yasuyoshi

IPC分类号： C07C41/40 ,  A23K20/111 ,  A23L2/52 ,  A23L33/10 ,  A61K31/122 ,  A61K9/28 ,  A61Q19/00 ,  C07C43/23 ,  C07C41/46

CPC分类号： C07C49/577 ,  A23K20/111 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/347 ,  A61K9/28 ,  A61K31/122 ,  A61Q19/00 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23 ,  C07C45/81

摘要： With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54 ± 2°C during temperature rise at a rate of 5°C/min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2¸ ± 0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu-K±) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.

公开(公告)号：EP2004578B1

公开(公告)日：2014-09-03

申请号：EP07727357.1

申请日：2007-03-26

申请人： BASF SE

发明人： HECHLER, Claus ,  RUPPEL, Wilhelm ,  GERLINGER, Wolfgang ,  SCHNEIDER, Wolfgang ,  MÜLLER-ENGEL, Klaus Joachim

IPC分类号： C07C5/333 ,  C07C11/06

CPC分类号： B01J8/008 ,  B01J8/0453 ,  B01J8/0492 ,  B01J2208/00061 ,  B01J2208/00522 ,  B01J2208/00548 ,  C07B35/04 ,  C07C5/48 ,  C07C45/33 ,  C07C45/35 ,  C07C45/783 ,  C07C45/81 ,  C07C51/215 ,  C07C51/252 ,  C07C51/43 ,  C07C11/06 ,  C07C57/04 ,  C07C47/22

公开(公告)号：EP1620382B1

公开(公告)日：2013-09-04

申请号：EP04729444.2

申请日：2004-04-26

申请人： BASF SE

发明人： HÜSLER, Rinaldo ,  HORNI, Thomas

IPC分类号： C07C45/46 ,  C07C45/63 ,  C07C45/64 ,  C07C45/81 ,  C07C49/792 ,  C07C49/813 ,  C07C49/83 ,  C08F2/50 ,  G03F7/031

CPC分类号： C08F2/50 ,  C07C45/46 ,  C07C45/63 ,  C07C45/64 ,  C07C45/81 ,  C07C49/792 ,  C07C49/813 ,  C07C49/83

公开(公告)号：EP2630120A1

公开(公告)日：2013-08-28

申请号：EP11778981.8

申请日：2011-10-19

申请人： Actelion Pharmaceuticals Ltd.

发明人： ABELE, Stefan ,  FUNEL, Jacques-Alexis

IPC分类号： C07C305/20

CPC分类号： C07C45/64 ,  C07B2200/07 ,  C07C45/66 ,  C07C45/72 ,  C07C45/81 ,  C07C309/25 ,  C07C309/66 ,  C07C2602/44 ,  C07C49/747 ,  C07C49/683

摘要： The present invention relates to a new process for the diastereoselective preparation of (1R*,4R*,5S*,6S*)-6-hydroxy-5-arylbicyclo[2.2.2]octan-2-one compounds, the compounds of the formula (II), which may subsequently be further transformed to 5-aryl-bicyclo[2.2.2]oct-5-en-2-one compounds of the formula (I): The present invention further relates to novel (1R*,2S*,3S*,4R*)-6-oxo-3-arylbicyclo[2.2.2]octan-2-yl methanesulfonate compounds as such, which compounds are useful intermediates in the preparation of 5-aryl-bicyclo[2.2.2]oct-5-en-2-one compounds of the formula (I).

摘要翻译： 本发明涉及非对映选择性制备（1R *，4R *，5S *，6S *）-6-羟基-5-芳基双环[2.2.2]辛-2-酮化合物的新方法， 式（II），其可以随后进一步转化为式（I）的5-芳基 - 双环[2.2.2]辛-5-烯-2-酮化合物：本发明还涉及新的（1R *， 2S *，3S *，4R *）-6-氧代-3-芳基双环[2.2.2]辛-2-基甲磺酸酯化合物，这些化合物是制备5-芳基 - 双环[2.2.2 ]辛-5-烯-2-酮化合物。

公开(公告)号：EP2538802A1

公开(公告)日：2013-01-02

申请号：EP11705518.6

申请日：2011-02-21

申请人： Rhodia Operations

发明人： LE-THIESSE, Jean-Claude ,  LAMIRI, Kilani

IPC分类号： A23L1/226 ,  A61K8/33 ,  A61K47/08 ,  C07C45/81 ,  C11B9/00 ,  C11D3/50 ,  C07C47/58 ,  C07C47/575

CPC分类号： A23L1/22657 ,  A23K20/111 ,  A23L27/20 ,  A23L27/204 ,  A61K8/33 ,  A61K8/347 ,  A61K47/08 ,  A61Q13/00 ,  A61Q19/00 ,  C07C45/81 ,  C11B9/0061 ,  C11D3/50 ,  C07C47/58 ,  C07C47/575

摘要： The invention relates to a method for preparing a composition essentially including a compound containing vanillin and ethylvanillin. The method for preparing a composition essentially including a compound containing vanillin and ethylvanillin according to a vanillin/ethylvanillin molar ratio of 2 is characterized in that it includes an operation of co-granulating vanillin and ethylvanillin at a temperature of between 50°C and 57°C in the form of a powder and in amounts such that the vanillin/ethylvanillin molar ratio is at least equal to 2, and an operation of lowering the temperature of the composition thus obtained to room temperature.

公开(公告)号：EP1752439B9

公开(公告)日：2012-06-27

申请号：EP06118168.1

申请日：2006-07-31

申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： Amemiya, Junichi ,  Watanabe, Masafumi ,  Kuzuhara, Ikutaro

IPC分类号： C07C47/19 ,  C07C45/75 ,  C07C45/80 ,  C07C45/81 ,  C07C45/82 ,  C07D319/06

CPC分类号： C07C45/75 ,  C07C45/80 ,  C07C45/81 ,  C07C45/82 ,  C07D319/06 ,  C07C47/19

公开(公告)号：EP2406207A1

公开(公告)日：2012-01-18

申请号：EP10713146.8

申请日：2010-03-10

申请人： Lamberti Spa

发明人： LI BASSI, Giuseppe ,  NORCINI, Gabriele ,  FEDERICI, Leonardo

IPC分类号： C07C45/81 ,  C07C49/83 ,  C08F2/50 ,  G03F7/031

CPC分类号： C08F2/50 ,  C07C45/81 ,  G03F7/031 ,  C07C49/82

摘要： Process for the preparation of the powdery crystalline mixtures of alpha-hydroxycarbonyl derivatives of alpha-methylstyrene dinners comprising the use of a solvent having polarity from 0 to 0.1.

公开(公告)号：EP2041059B1

公开(公告)日：2010-06-16

申请号：EP07765652.8

申请日：2007-06-27

申请人： BASF SE

发明人： TELES, Joaquim Henrique ,  RÖSSLER, Beatrice ,  PINKOS, Rolf ,  TEBBEN, Gerd ,  MÜLLER, Christian ,  RUST, Harald

IPC分类号： C07C45/28 ,  C07C45/62 ,  C07C45/85 ,  C07C49/413 ,  C07C49/607

CPC分类号： C07C45/28 ,  C07C45/62 ,  C07C45/80 ,  C07C45/81 ,  C07C45/82 ,  C07C45/85 ,  C07C2601/18 ,  C07C2601/20 ,  C07C49/607 ,  C07C49/413

摘要： The invention relates to a method for producing a cyclic ketone that has 7 to 16 C atoms. Said method encompasses at least the following stages: (a) a composition (i) at least containing a cyclic alkene with 7 to 16 C atoms, including at least one C-C double bond, is oxidized by means of dinitrogen monoxide so as to obtain a composition (A); (b) composition (A) is treated with at least one base so as to obtain a composition (B); (c) composition (B) is hydrogenated in the presence of at least one catalyst so as to obtain a composition (C); (d) composition (C) is purified in at least the following steps: (di) composition (C) is thermally treated with at least one acid or at least one catalyst containing at least one transition metal; (dii) composition (C) is further purified by means of a process selected from the group comprising distillation, extraction, and crystallization.

摘要翻译： 本发明涉及一种制备具有7至16个碳原子的环酮的方法，其至少包括步骤（a）包含至少一种具有7至16个碳原子的环烯烃的组合物（I）的氧化 和至少一种C-C双键，得到组合物（A），（b）用至少一种碱处理组合物（A），得到组合物（B），（c）氢化 在组合物（B）的存在下，在至少一种催化剂的存在下，得到组合物（C），（d）组合物（C）的纯化，至少包括步骤（ii）组合物（C）的热处理， 至少一种酸或至少一种包含至少一种过渡金属的催化剂，（dii）通过选自蒸馏，萃取和结晶的方法进一步纯化。

公开(公告)号：EP2114846A1

公开(公告)日：2009-11-11

申请号：EP08716098.2

申请日：2008-02-28

申请人： DSM IP Assets B.V.

发明人： BREUNNINGER, Manfred ,  JORAY, Marcel

IPC分类号： C07C37/00 ,  C07C39/08 ,  C07C45/64

CPC分类号： C07C45/64 ,  C07C37/002 ,  C07C39/11 ,  C07C45/46 ,  C07C45/80 ,  C07C45/81 ,  C07C49/825 ,  C07C49/82

摘要： Process for the preparation of hydroxytyrosol, characterized by reacting 4- chloroacetyl-catechol with a metal formate and formic acid in an aqueous solvent optionally containing a lower alkanol and catalytically hydrogenating the 4- hydroxyacetyl-catechol obtained in the presence of a precious metal, preferably on a carrier.

公开(公告)号：EP2041059A1

公开(公告)日：2009-04-01

申请号：EP07765652.8

申请日：2007-06-27

申请人： BASF SE

发明人： TELES, Joaquim Henrique ,  RÖSSLER, Beatrice ,  PINKOS, Rolf ,  TEBBEN, Gerd ,  MÜLLER, Christian ,  RUST, Harald

IPC分类号： C07C45/28 ,  C07C45/62 ,  C07C45/85 ,  C07C49/413 ,  C07C49/607

CPC分类号： C07C45/28 ,  C07C45/62 ,  C07C45/80 ,  C07C45/81 ,  C07C45/82 ,  C07C45/85 ,  C07C2601/18 ,  C07C2601/20 ,  C07C49/607 ,  C07C49/413

摘要： The invention relates to a method for producing a cyclic ketone that has 7 to 16 C atoms. Said method encompasses at least the following stages: (a) a composition (i) at least containing a cyclic alkene with 7 to 16 C atoms, including at least one C-C double bond, is oxidized by means of dinitrogen monoxide so as to obtain a composition (A); (b) composition (A) is treated with at least one base so as to obtain a composition (B); (c) composition (B) is hydrogenated in the presence of at least one catalyst so as to obtain a composition (C); (d) composition (C) is purified in at least the following steps: (di) composition (C) is thermally treated with at least one acid or at least one catalyst containing at least one transition metal; (dii) composition (C) is further purified by means of a process selected from the group comprising distillation, extraction, and crystallization.

摘要翻译： 本发明涉及生产具有7至16个C原子的环酮的方法。 所述方法至少包括以下阶段：（a）通过一氧化二氮将至少含有具有7至16个C原子的环烯烃（包括至少一个CC双键）的组合物（i）用一氧化二氮氧化以获得 组成（A）; （b）用至少一种碱处理组合物（A）以获得组合物（B）; （c）将组合物（B）在至少一种催化剂存在下氢化以获得组合物（C）; （d）至少在下列步骤中纯化组合物（C）：（di）用至少一种酸或至少一种含至少一种过渡金属的催化剂热处理组合物（C）; （dii）组合物（C）通过选自蒸馏，萃取和结晶的方法进一步纯化。