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公开(公告)号：EP2910634B1
公开(公告)日：2018-12-05
申请号：EP13848760.8
申请日：2013-10-18
发明人： YOKOGAWA Kenji , WAKI Takashi , HONDA Yoko , UEFUJI Hirotaka , SEWAKI Tomomitsu , ARAKAWA Takeshi , HARAKUNI Tetsuya , MIYATA Takeshi
IPC分类号： C12N15/09 , A61K39/00 , A61K39/385 , A61K39/395 , A61K47/42 , A61K48/00 , A61P31/04 , C07K14/195 , C07K14/395 , C07K14/47 , C07K16/12 , C07K16/14 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , G01N33/53
CPC分类号： C07K14/245 , A61K39/0005 , A61K39/0258 , A61K2039/53 , A61K2039/552 , C07K14/435 , C07K16/1232 , C07K16/18 , C07K2317/76 , C07K2319/21 , C07K2319/55 , C07K2319/73 , Y02A50/474
摘要： A purpose is to provide a vaccine which can prevent porcine edema disease in farms where porcine edema disease is anticipated. Meeting this purpose is a vaccine that is a fusion protein in which Stx2eB and a polypeptide having a coiled-coil forming unit are joined or a multimer of the fusion protein, and by immunizing pigs with this vaccine, it is possible to induce potent neutralizing antibodies and to defend against the onset of porcine edema disease.
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公开(公告)号：EP3389704A1
公开(公告)日：2018-10-24
申请号：EP16822409.5
申请日：2016-12-15
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Paul Sabatier Toulouse III , Centre Hospitalier Universitaire de Toulouse
CPC分类号： A61K39/0216 , A61K2039/51 , A61K2039/521 , A61K2039/522
摘要： The present invention concerns a composition comprising at least one prophylactically or therapeutically active agent selected from the group consisting of attenuated Porphyromonas gingivalis, inactivated Porphyromonas gingivalis, a subunit of Porphyromonas gingivalis, a recombinant or isolated immunogenic polypeptide or peptide from Porphyromonas gingivalis or a c DNA from Porphyromonas gingivalis, for use as a vaccine for preventing or treating periodontitis, diabetes, obesity and/or complications thereof in a subject. The present invention also concerns an isolated antibody having specificity for Porphyromonas gingivalis for use for preventing or treating periodontitis, diabetes, obesity and/or complications thereof in a subject.
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公开(公告)号：EP3388071A1
公开(公告)日：2018-10-17
申请号：EP18174953.2
申请日：2011-07-25
申请人： Cellestis Limited
IPC分类号： A61K38/16 , C07K14/35 , C07K16/12 , C12N5/00 , C12Q1/68 , G01N33/569 , A61K38/10 , G01N33/68
CPC分类号： G01N33/56972 , A61K38/10 , A61K38/164 , C07K7/08 , C07K14/35 , G01N33/5695 , G01N33/6866 , G01N2333/35 , G01N2333/57
摘要： The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
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公开(公告)号：EP2739636B1
公开(公告)日：2018-09-26
申请号：EP12740904.3
申请日：2012-07-30
IPC分类号： C07H3/06 , C07H3/08 , C07H13/08 , C07H15/04 , C07H15/20 , C07H5/04 , A61K31/7032 , A61P31/04 , A61P1/12 , C07K16/12 , G01N33/569
CPC分类号： C07H3/06 , C07H3/08 , C07H5/04 , C07H13/08 , C07H15/04 , C07H15/20 , C07K16/1282 , G01N33/56911
摘要： The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide ±-L-Rha p -(1†’3)-²-D-Glc p -(1†’4)-[±-L-Rha p -(1†’3)]-±-D-Glc p -(1†’2)-±-D-Glc p or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools. A preferred method for synthesizing the pentasaccharide is shown below.
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公开(公告)号：EP2748302B1
公开(公告)日：2018-08-15
申请号：EP12753463.4
申请日：2012-08-22
申请人： Glycotope GmbH
CPC分类号： A61K39/0216 , A61K39/0011 , A61K2039/5154 , A61K2039/585 , C07K16/1257 , C12N1/20 , C12R1/01
摘要： The present invention pertains to microorganisms of the species Bacteroides xylanisolvens expressing a core-1 antigen on their surface. These microorganisms are in particular useful for the prophylaxis and treatment of core-1 positive diseases and are particularly characterized by a stable, homogenous high core-1 expression. Also provided are pharmaceutical compositions which comprise respective core-1 positive microorganisms or fractions thereof.
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76.发明公开
公开(公告)号：EP3353201A1
公开(公告)日：2018-08-01
申请号：EP16775571.9
申请日：2016-09-22
CPC分类号： C07K16/18 , A61K47/65 , A61K47/6889 , C07K1/1075 , C07K16/00 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/64 , C07K2319/00 , C07K2319/50 , C12N9/52 , C12Y304/2207
摘要： The present disclosure relates to a recombinant immunoglobulin heavy chain comprising a VH-domain a CH1 domain a hinge region down to the C-terminal most cysteine of the middle hinge region, a sortase conjugation loop, a CH2 domain and a CH3 domain, wherein the sortase conjugation loop a) consists of at least 16 amino acids located between the C-terminal most cysteine of the middle hinge region and the VFX1FPP (SEQ ID NO: 2; wherein X1 is L or I) consensus sequence at the N-terminus of an immunoglobulin heavy chain CH2-domain, b) comprises a sortase recognition motif consisting of the amino acid sequence LPX1TX2 (SEQ ID NO: 01), wherein X1 can be any amino acid residue and X2 is G or A, c) comprises N-terminal to the sequence of (b) at least two amino acids, d) comprises C-terminal to the sequence of (b) at least 6 amino acids, and e) wherein the amino acids C- and N-terminal to the sequence of (b) are not cysteine and its use in site-directed conjugation based on the enzyme sortase.
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公开(公告)号：EP2751563B1
公开(公告)日：2018-08-01
申请号：EP12848661.0
申请日：2012-11-09
IPC分类号： G01N33/569 , C07K16/12 , G01N33/53
CPC分类号： G01N33/56938 , C07K16/1271 , G01N33/53
摘要： The present invention provides methods and devices for detecting the presence of biomolecules in a biological sample, such as PVL, PBP2a and SPA.
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公开(公告)号：EP3256855A4
公开(公告)日：2018-07-11
申请号：EP16749961
申请日：2016-02-12
发明人： POLLOCK NIRA , KEELY CIARAN , DUFFY DAVID C , SONG LINAN , ZHAO MINGWEI
IPC分类号： G01N33/569 , C07K14/33 , C07K16/12
CPC分类号： C07K14/33 , C07K16/1282 , C07K2317/33 , G01N33/56911 , G01N2333/33
摘要： Ultrasensitive and quantitative assays for detecting toxins of Clostridium difficile, which may involve digital ELISA, are provided. Also provided herein are differential detection assays that allow for distinguishing toxin B of highly virulent Clostridium difficile strains from toxin B of less virulent strains.
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公开(公告)号：EP3327030A1
公开(公告)日：2018-05-30
申请号：EP17206527.8
申请日：2008-09-25
发明人： ALTERMANN, Eric Heinz , ATTWOOD, Graeme Trevor , LI, Dong , KELLY, William John , KONG, Zhanhao , LEAHY, Sinead
IPC分类号： C07K14/345 , A61K39/02 , C07K16/12
CPC分类号： C07K14/005 , A61K35/13 , C07K2319/00 , C12N1/20 , C12N7/00 , C12N9/641 , C12N2795/10021 , C12N2795/10022
摘要： The invention encompasses components from microbial cells which are useful for antibody production, including peptides, polypeptides comprising these peptides, polynucleotides which encode these peptides or polypeptides, and antibodies directed to these peptides, polypeptides, or polynucleotides. The invention also encompasses to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further encompasses methods and compositions, especially vaccine compositions, for detecting, targeting, and inhibiting microbial cells, especially methanogen cells, using one or more of the disclosed peptides, polypeptides, polynucleotides, antibodies, expression vectors, and host cells.
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公开(公告)号：EP3322721A1
公开(公告)日：2018-05-23
申请号：EP16742211.2
申请日：2016-07-14
申请人： NAVIGO PROTEINS GMBH
发明人： HAUPTS, Ulrich
CPC分类号： C07K16/46 , C07K1/22 , C07K14/31 , C07K16/1271 , C07K2317/92
摘要： The present disclosure relates to non-natural binding proteins comprising one or more non-natural immunoglobulin (Ig) binding domains wherein at least one non-natural lg-binding domain comprises the amino acid sequence X1 X2X3XiXsX5X7 XsQQX11AFYX1sX15LX1 sX19PX21 LX23X24X2sQRX28X2gf IQSLKDDPSXio SXi2Xi3Xi4LXi5EAXigKLXs2Xs3Xs4QXs5PX. The disclosure also relates to compositions such as affinity matrices comprising the non-natural Ig-binding proteins of the invention. Use of these Ig-binding proteins or of the compositions for affinity purification of immunoglobulins and to methods of affinity purification.
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