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公开(公告)号：EP0861086A1
公开(公告)日：1998-09-02
申请号：EP96939682.0
申请日：1996-11-13
申请人： FIBROGEN, INC.
CPC分类号： C07K14/78 , C07K2319/00
摘要： The present invention relates to novel collagens, polynucleotide sequences encoding these novel proteins, and to the use of these novel proteins and polynucleotides in the diagnosis and treatment of disease. The present invention further relates to specific collagens and derivatives, specifically fusion proteins of type IX collagen with type II and/or type XI collagens, and their use as therapeutic agents.
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公开(公告)号：EP3124489B1
公开(公告)日：2020-07-15
申请号：EP16174358.8
申请日：2007-04-04
申请人： Fibrogen, Inc.
发明人： DENG, Shaojiang , WU, Min , TURTLE, Eric D. , HO, Wen-Bin , AREND, Michael P. , CHENG, Heng , FLIPPIN, Lee A.
IPC分类号： C07D513/04 , A61K31/4365 , A61P7/06 , A61P9/10
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公开(公告)号：EP3520784A1
公开(公告)日：2019-08-07
申请号：EP19172616.5
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen J. , LIN, Al Y. , NEFF, Thomas B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/4745 , A61K31/496 , A61K31/63 , C07K14/505 , A61K31/00 , C07K14/47 , G01N33/74 , A61K38/17
摘要： The present invention relates to methods for treating anemia by increasing endogenous erythropoietin via inhibition of HIF prolyl hydroxylase enzyme activity.
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公开(公告)号：EP3386544A1
公开(公告)日：2018-10-17
申请号：EP16873677.5
申请日：2016-12-06
申请人： Fibrogen, Inc.
发明人： BRANDAN, Enrique , GONZALEZ, David
IPC分类号： A61K39/395 , A61K48/00 , C07K14/475 , A61P21/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/475 , C07K2317/21 , Y02A50/466
摘要： The invention relates to methods and agents useful for treating motor neuron diseases (MNDs), in particular, amyotrophic lateral sclerosis (ALS). Methods and agents for treating various physiological and pathological conditions associated with motor neuron diseases are also provided.
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公开(公告)号：EP2289531B1
公开(公告)日：2018-07-04
申请号：EP10181768.2
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： Klaus, Stephen J. , Lin, Al Y. , Neff, Thomas B. , Wang, Qingjian , Guenzler-Pukall, Volkmar , Arend, Michael P. , Flippin, Lee A.
IPC分类号： A61K38/00 , C12N15/09 , C12Q1/56 , C12Q1/34 , A61K31/00 , A61K31/47 , A61K31/4738 , A61K31/63 , A61P7/06 , A61K38/17 , C07K14/47 , C07K14/505 , G01N33/74 , A61K31/472 , A61K31/4745 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/496
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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86.发明公开CRYSTALLINE FORMS OF {[1-CYANO-5-(4-CHLOROPHENOXY)-4-HYDROXY-ISOQUINOLINE-3-CARBONYL]-AMINO}-ACETIC ACID 审中-公开{[1-氰基-5-（4-氯苯氧基）-4-羟基 - 异喹啉-3-羰基] - 氨基} - 乙酸的结晶形式
公开(公告)号：EP2951159A1
公开(公告)日：2015-12-09
申请号：EP14704030.7
申请日：2014-01-23
申请人： Fibrogen, Inc.
IPC分类号： C07D217/26 , A61K31/472 , A61P7/06
CPC分类号： C07D217/26
摘要： The present disclosure relates to crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid (Compound A), the process of preparing crystalline forms of Compound A, the pharmaceutical compositions containing them, and the methods of use thereof.
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公开(公告)号：EP2822545A4
公开(公告)日：2015-08-12
申请号：EP13758366
申请日：2013-03-08
申请人： FIBROGEN INC
发明人： LIN AL Y , NEFF THOMAS B , YU KIN-HUNG
IPC分类号： A61K31/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/472 , A61K45/06 , C07D217/26 , A61K2300/00
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公开(公告)号：EP2826471A1
公开(公告)日：2015-01-21
申请号：EP14178232.6
申请日：2004-06-04
申请人： Fibrogen, Inc.
发明人： Klaus, Stephen J. , Molineaux, Christopher J. , Neff, Thomas B. , Guenzler-Pukall, Volkmar , Lansetmo Parobok, Ingrid , Seeley, Todd W. , Stephenson, Robert C.
IPC分类号： A61K31/00 , A61K31/395 , A61K31/165 , A61P7/06
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
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公开(公告)号：EP1232181B1
公开(公告)日：2013-03-27
申请号：EP00978455.4
申请日：2000-11-10
申请人： Fibrogen, Inc.
发明人： CHANG, Robert, C. , KIVIRIKKO, Kari, I. , NEFF, Thomas, B. , OLSEN, David, R. , POLAREK, James, W.
IPC分类号： A23L1/0562 , C07K14/78 , A61K47/42 , A61K8/65 , A61Q19/00 , C08H1/06 , C08L89/06 , G03C1/047 , A61K9/00
CPC分类号： C07K14/78 , A23L29/284 , A61K8/65 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K2800/86 , A61Q19/00 , C08H1/06 , C08L89/06 , G03C1/047
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公开(公告)号：EP2295060A3
公开(公告)日：2013-03-13
申请号：EP10181210.5
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： Guenzler-Pukall, Volkmar , Neff, Thomas B. , Wang, Qingjian , Flippin, Lee A. , Arend, Michael P.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06 , A61P9/10 , G01N33/74 , C12N15/09 , C12Q1/34 , C12Q1/56
CPC分类号： A61K31/00 , A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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