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公开(公告)号：EP1682543B1
公开(公告)日：2010-08-18
申请号：EP04791030.2
申请日：2004-10-29
IPC分类号： C07D451/10 , A61K31/46 , A61P11/00
CPC分类号： C07D451/10
摘要： The invention relates to novel tiotropium salts, methods for the production thereof, pharmaceutical formulations containing the same, and the use thereof for producing a medicament that is used for the treatment of respiratory diseases, especially COPD (chronic obstructive pulmonary disease) and asthma.
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公开(公告)号：EP2195431A1
公开(公告)日：2010-06-16
申请号：EP08803328.7
申请日：2008-08-28
IPC分类号： C12N15/13 , C12N15/85 , C07K16/00 , C07K14/505 , C12N9/72
CPC分类号： C07K16/00 , C07K16/40 , C07K2317/24 , C07K2317/52
摘要： The invention relates to methods for increasing the titer of a protein of interest in a cell as well as enhancing production and purification of optimized biomolecules, the component of which is, inter alia, the CH3 domain. In biomolecules, the C-terminal amino acid(s), e.g. the C-terminal lysine, frequently separate(s). The mostly incomplete processing of, for example, the heavy chain of antibodies results in products being heterogeneous. In order to avoid said product heterogeneity, the respective codon of the C-terminal lysine of the heavy antibody chain is deleted using recombinant DNA technology. Said optimized antibodies result in an increased product titer than in the wild type. In addition, said optimized antibodies are advantageous in the purification process as a result of an improved elution behavior due to the reduced charge heterogeneity.
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83.发明公开CD200 AND ITS RECEPTOR, CD200R, MODULATE BONE MASS VIA THE DIFFERENTIATION OF OSTEOCLASTS 审中-公开CD200受体确保两CD200R骨量的调制信号被破骨细胞分化
公开(公告)号：EP2121015A4
公开(公告)日：2010-03-24
申请号：EP08727510
申请日：2008-01-10
发明人： VIGNERY AGNES , KE JUAN ZHANG , LI JUN
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K38/177 , A61K38/1774 , A61K2039/505
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84.发明公开In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel 审中-公开在6-位取代的吲哚酮，它们的制备和它们作为药物的用途
公开(公告)号：EP2157081A1
公开(公告)日：2010-02-24
申请号：EP09164507.7
申请日：2000-10-09
发明人： Heckel, Armin , Roth, Gerlad, Juergen , Walter, Rainer , Van Meel, Jacobus , Redemann, Norbert , Tontsch-Grunt, Ulrike , Spevak, Walter , Hilberg, Frank
IPC分类号： C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , A61K31/404
CPC分类号： C07D403/12 , C07D209/30 , C07D209/34 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12
摘要： Die vorliegende Erfindung betrifft in 6-Stellung substituierte Indolinone der allgemeinen Formel
in der
R 1 bis R 5 und X wie im Anspruch 1 definiert sind, deren Isomere und deren Salze, insbesondere deren physiologisch verträgliche Salze, welche wertvolle pharmakologische Eigenschaften aufweisen, insbesondere eine inhibierende Wirkung auf verschiedene Rezeptor-Tyrosinkinasen und Cyclin/CDK-Komplexe sowie auf die Proliferation von Endothelzellen und verschiedener Tumorzellen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung.摘要翻译： 本发明涉及通式的6-取代吲哚满酮，其中R 1至R 5和X如权利要求1中所定义，包括异构体和其盐，尤其是生理学可接受的盐，它们具有有价值的药理性质，特别是抑制 在各种受体酪氨酸激酶和细胞周期蛋白/ CDK复合物和在内皮细胞和各种肿瘤细胞中，含有这些化合物，它们的用途和它们的制备方法的药物的扩散效果。
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公开(公告)号：EP2155748A1
公开(公告)日：2010-02-24
申请号：EP08769442.8
申请日：2008-05-12
发明人： COOK, Brian Nicholas , ELDRUP, Anne Bettina , MUGGE, Ingo Andreas , SOLEYMANZADEH, Fariba , SUN, Sanxing , ZHANG, Yunlong
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/12
CPC分类号： C07D471/04
摘要： Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6, W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.
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86.发明授权SYSTEM ZUR ÜBERPRÜFUNG VON SYTEMEN, DIE IHRERSEITS ZUR ÜBERPRÜFUNG DER DICHTIGKEIT EINES HOHLKÖRPERS DIENEN 有权SYSTEM FOR REVIEW SYTEMEN的这反过来对密封件的审查的空心体SERVE
公开(公告)号：EP1388003B1
公开(公告)日：2010-02-24
申请号：EP02727556.9
申请日：2002-04-12
发明人： KÜHN, Torsten
IPC分类号： G01M3/00
CPC分类号： G01M3/007
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87.发明授权HERSTELLUNG VON 1,7` -DIMETHYL-2` -PROPYL-2,5` -BI-1H-BENZIMIDAZOL 有权二甲酯的生产1,7`-2`丙基2,5` -BI -1H-苯并咪唑
公开(公告)号：EP1912951B1
公开(公告)日：2010-01-06
申请号：EP06764180.3
申请日：2006-07-17
IPC分类号： C07D235/18
CPC分类号： C07D235/18
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88.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开糖皮质激素类似物，其制造，药物组合物及其使用方法
公开(公告)号：EP2136811A1
公开(公告)日：2009-12-30
申请号：EP08745327.0
申请日：2008-04-09
IPC分类号： A61K31/535
CPC分类号： C07C323/49 , C07C311/17 , C07C311/18 , C07C311/41 , C07C2602/08 , C07C2602/10
摘要： Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, X, R7, and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 如定义在（i）其中R1，R2，R3，R4，R5，R6，X，R7，R8和式I的化合物，或其互变异构体，前药，溶剂化物，或它们的盐; 药物组合物含有受试化合物，并调节糖皮质激素受体功能的方法和治疗疾病状态或由糖皮质激素受体功能中使用这些化合物的患者介导的或特征为炎性，过敏性或增生性过程病症的方法。
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89.发明授权CRYSTALLINE FORM OF 1-CHLORO-4-(ß-D-GLUCOPYRANOS-1-YL)-2-[4-((S)-TETRAHYDROFURAN-3-YLOXY)-BENZYL]-BENZENE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS 有权的结晶形式的1-氯-4-（β-D-吡喃葡萄糖-1-基）-2- [4 - （（S） - 四氢呋喃-3-基氧基） - 苄基] - 苯，其制造方法及其使用 生产药物的
公开(公告)号：EP1888552B1
公开(公告)日：2009-12-23
申请号：EP06763074.9
申请日：2006-05-02
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , SICK, Sandra , SCHUEHLE, Martin , MARTIN, Hans-Jürgen
IPC分类号： C07D309/10 , A61K31/351
CPC分类号： C07H15/00 , C07D405/12
摘要： The invention relates to a crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((Sj-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
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90.发明授权ARZNEIMITTELKOMPOSITIONEN AUS TIOTROPIUMSALZEN UND EPINASTIN ZUR THERAPIE VON ATEMSWEGSERKRANKUNGEN 有权药物成分和噻托溴盐依匹斯汀用于治疗呼吸疾病LANE
公开(公告)号：EP1341538B1
公开(公告)日：2009-12-23
申请号：EP01982446.5
申请日：2001-10-23
发明人： PAIRET, Michel , PIEPER, Michael, Paul , MEADE, Christopher, John, Montague , SCHMELZER, Christel
CPC分类号： A61K45/06 , A61K9/0043 , A61K9/0073 , A61K31/439 , A61K31/46 , A61K31/4745 , A61K31/496 , A61K31/55 , A61K31/56 , A61K31/57 , A61K31/58 , A61K2300/00
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