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公开(公告)号：EP3289362A1
公开(公告)日：2018-03-07
申请号：EP16719414.1
申请日：2016-04-29
CPC分类号： B01L3/502784 , B01L3/502761 , B01L2200/0652 , G01N15/1459 , G01N15/1484 , G01N33/5094 , G01N33/58 , G01N2015/149
摘要： The present invention relates to the field of microfluidics and in particular to methods for detecting microfluidic droplets and particles within droplets, as well as sorting the droplets. These methods allow for quantifying properties and activities of the particles within the droplets. For this purpose, the invention provides microfluidic droplets comprising suitably labelled particles. The invention also provides microfluidic devices and systems having properties which make them particularly suitable for use in the methods of the invention.
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公开(公告)号：EP3267345A1
公开(公告)日：2018-01-10
申请号：EP16178113.3
申请日：2016-07-06
IPC分类号： G06F19/12
CPC分类号： G06F19/12
摘要： The invention relates to adaptive laboratory evolution of cells and/or organisms. In particular, the invention relates to a method for adaptive laboratory evolution of cells or organisms in order to generate desired metabolic traits without the need of genetic engineering. In addition, the invention provides a computer program element and a computer readable medium. Further, the invention relates to cells or organisms obtained by the method of the invention.
摘要翻译： 本发明涉及细胞和/或生物体的适应性实验室进化。 具体而言，本发明涉及用于细胞或生物适应性实验室进化以产生期望的代谢性状而不需要基因工程的方法。 另外，本发明提供了一种计算机程序单元和一种计算机可读介质。 此外，本发明涉及通过本发明的方法获得的细胞或生物体。
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公开(公告)号：EP2087392B1
公开(公告)日：2018-01-10
申请号：EP07801320.8
申请日：2007-09-07
CPC分类号： G02B21/24 , G02B21/33 , G02B27/0006
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公开(公告)号：EP3159674A1
公开(公告)日：2017-04-26
申请号：EP15190403.4
申请日：2015-10-19
发明人： Svergun, Dmitri , Blanchet, Clement , Franke, Daniel , Gräwert, Melissa , Cipriani, Florent , Meijers, Rob , Dr. Dierks, Karsten , Dr. Eckhardt, Annette , Dr. Meyer, Arne , Prof. Betzel, Christian , Dr. Falke, Sven
IPC分类号： G01N21/51
CPC分类号： G01N15/0211 , G01N21/0303 , G01N21/51 , G01N23/201 , G01N2015/0038 , G01N2015/0222 , G01N2015/0693 , G01N2021/1734 , G01N2021/513
摘要： The present invention relates to a measurement cell which facilitates a small angle X-ray scattering measurement and facilitates dynamic light scattering measurements within the identical sample compartment of a sample holder. Light transportation means which are arranged and configured for transporting light of the light source towards the sample in the sample compartment and/or for transporting light scattered from the sample towards the detector are comprised. For example, a first and a second window which are optically transparent for the DLS light and the scattered light are presented. The first and second windows are provided at a sample holder which is specifically designed as a SAXS sample holder. Furthermore, a method of solution scattering for quality assessment of a sample is presented.
摘要翻译： 本发明涉及一种测量单元，其便于小角度X射线散射测量并且便于在样品架的相同样品室内进行动态光散射测量。 包括布置和构造用于将光源的光朝向样品室中的样品传送和/或用于将从样品散射的光朝检测器传送的光传送装置。 例如，呈现对于DLS光和散射光光学透明的第一和第二窗口。 第一个和第二个窗口设置在专门设计为SAXS样品架的样品架上。 此外，还介绍了一种用于样品质量评估的溶液散射方法。
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公开(公告)号：EP3114522A2
公开(公告)日：2017-01-11
申请号：EP15707995.5
申请日：2015-03-06
发明人： HUFNAGEL, Lars , KRZIC, Uros , LIEBEL, Urban
CPC分类号： G02B21/362 , G02B21/06 , G02B21/16 , G02B21/26 , G02B21/28
摘要： An imaging device for a microscope (20) is disclosed that comprises a plurality of moveable light sources (40) and a detector (15). The plurality of the light sources (40) is mounted on a translation stage (110). The imaging device further includes moveable optics arranged to direct a light path (45) onto a stationary sample (60) and collect reflected or fluoresced radiation from the sample (60).
摘要翻译： 公开了一种用于显微镜（20）的成像装置，其包括多个可移动光源（40）和检测器（15）。 多个光源（40）安装在平移台（110）上。 成像装置还包括可移动光学器件，其布置成将光路（45）引导到固定样品（60）上并收集来自样品（60）的反射或发射的辐射。
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公开(公告)号：EP3094977A1
公开(公告)日：2016-11-23
申请号：EP15703230.1
申请日：2015-01-14
发明人： LEMKE, Edward , SCHULTZ, Carsten , PLASS, Tillmann , NIKIC, Ivana , HOFFMANN, Jan-Erik , VALLE ARAMBURU, Iker
IPC分类号： G01N33/58 , C07C271/22 , C07C271/34
CPC分类号： C07C271/22 , C07C271/34 , G01N33/533 , G01N33/582
摘要： The present invention relates to methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-labeling strategies. In particular, the invention relates to methods for forming linkages by cycloaddition reactions, wherein the method comprises reacting a first alkyl-substituted tetrazine with a first dienophile comprising a irans-cyclooctenyl group followed by reacting a second tetrazine with a second dienophile comprising a cyclooctynyl group, wherein the reaction of the first tetrazine with the first dienophile proceeds in the presence of the second dienophile.
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87.发明公开
公开(公告)号：EP2943495A1
公开(公告)日：2015-11-18
申请号：EP14703275.9
申请日：2014-01-07
发明人： Wolkerstorfer, Andrea , Szolar, Oliver , Handler, Norbert , Buschmann, Helmut , Cusack, Stephen , Smith, Mark , So, Sung-Sau , Hawley, Ronald Charles , Sidduri, Achyutharao , Zhang, Zhuming
IPC分类号： C07D487/04 , A61K31/519 , A61P31/12
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D403/04 , C07D471/04
摘要： The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph,codrug, cocrystal,prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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88.发明公开PYRIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 审中-公开吡啶酮衍生物和它们在治疗，减轻或预防的疾病病毒的使用
公开(公告)号：EP2943469A1
公开(公告)日：2015-11-18
申请号：EP14703276.7
申请日：2014-01-07
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , BUSCHMANN, Helmut , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau , HAWLEY, Ronald Charles
IPC分类号： C07D213/78 , A61K31/4412 , A61P43/00
CPC分类号： C07D213/81 , A61K31/4412 , A61K45/06 , C07D213/78 , C07D213/79
摘要： The present invention relates to a compound having the general formula (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof (II), which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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89.发明公开AUTOMATION OF INCUBATION, PROCESSING, HARVESTING AND ANALYSIS OF SAMPLES IN A MULTI-CELL PLATE WITH THIN FILM SAMPLE SUPPORT 审中-公开AUTOMATED孵化，加工，收获和样品的分析，配合薄膜样本载体的多单元板
公开(公告)号：EP2936164A1
公开(公告)日：2015-10-28
申请号：EP13811205.7
申请日：2013-12-18
CPC分类号： B01L3/06 , B01L3/5085 , B01L3/50853 , B01L2200/025 , B01L2200/10 , B01L2300/044 , B01L2300/0893 , B01L2300/12 , B01L2300/16 , C12M23/12 , C12M41/36 , C12M41/48 , G01N1/04 , G01N35/0099 , G01N35/028 , G01N35/10 , G01N35/1079 , G01N2001/045 , G01N2035/0403
摘要： The present invention relates to the automation of incubation, processing, harvesting and analysis of samples in a multi-cell plate. In particular, a multi-cell plate including a body with a plurality of cells is presented. Furthermore, an automated crystal harvesting and processing system with a cutting unit, a fluid unit and a removing device is presented. The multi-cell plate further includes a sealing film for sealing the cells on a first side of the body and a sample film for sealing the cells on a second side of the body. The sample film is adapted for accommodating a biological material for crystallization. Furthermore, the sample film is of a thickness and composition that makes it compatible with x-rays and also with laser ablation. The design of the multi-cell plate and the automated crystal harvesting and processing system allows for several steps of incubation, processing, harvesting and analysis of the samples to be automated.
摘要翻译： 本发明涉及培育，处理，收获和在多单元板（1）的样品（15）的分析的自动化。 特别地，多单元板（1），包括主体（3）与细胞（5）的多元呈现。 进一步，自动化晶体收获和处理系统（21）配有一个切割单元（23），流体单元（29）和一个清除装置（33）被呈现。 多单元板（1）还包括一个密封的电影（7）（5）在第一侧上的密封的单元（9）的主体（3）和一个样本影片（11），用于密封所述电池（5） 在所述主体的第二侧（13）（3）。 样品电影（11）angepasst用于容纳用于结晶的生物材料（15）。 进一步，样品电影（11）是一个厚度的和组合物也使得它与X射线从而与激光烧蚀兼容。 多单元板（1）和自动晶体收获和处理系统（21）的设计允许（15），以进行自动化样品的温育后，处理，收获和分析的几个步骤。
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90.发明公开GIANT LIPOSOME ARRAY FOR HIGH-THROUGHPUT LIPID-INTERACTION SCREENING 审中-公开SEHR GROSSES LIPOSOMENARRAYFÜREIN LIPID-INTERAKTIONS-SCREENING MIT HOHEM DURCHSATZ
公开(公告)号：EP2875361A1
公开(公告)日：2015-05-27
申请号：EP13741705.1
申请日：2013-07-19
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N2405/04 , G01N2405/06 , G01N2570/00
摘要： The present invention relates to liposome arrays, devices comprising said liposome arrays, the uses of said liposome arrays as well as methods of producing said liposome arrays.
摘要翻译： 本发明涉及脂质体阵列，包含所述脂质体阵列的装置，所述脂质体阵列的用途以及产生所述脂质体阵列的方法。
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