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    ADHESIVE PREPARATIONS
    82.
    发明公开
    ADHESIVE PREPARATIONS 有权
    ADHÄSIVEZUBEREITUNGEN

    公开(公告)号：EP1238664A1

    公开(公告)日：2002-09-11

    申请号：EP00981746.1

    申请日：2000-12-15

    申请人： HISAMITSU PHARMACEUTICAL CO. INC.

    发明人： TSURUDA, Kiyomi, Hisamitsu Pharmaceutical Co. Inc. ,  IKEURA, Yasuhiro, Hisamitsu Pharmaceutical Co. Inc

    IPC分类号： A61K9/70 ,  A61K47/32

    CPC分类号： A61K9/7053 ,  A61K9/7076 ,  A61K47/32

    摘要： This invention provides a patch with less skin stimulation, excellent in long time store stability and heat stability and having favorable tack during use. The patch comprising a styrene - isoprene - styrene block copolymer, polyisobutylene, tackifier, plasticizer and pharmaceutically effective ingredient, in which two or more kinds of polyisobutylene of different average molecular weight are used in combination and the viscosity of the adhesive of the patch is between 1500 and 30,000 poise (at 60°C) and the tack of the patch is from 5 to 200 g/10 mm.

    摘要翻译： 本发明提供具有较少皮肤刺激的贴剂，在长时间储存​​稳定性和热稳定性方面优异，并且在使用期间具有良好的粘着性。 包含苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，聚异丁烯，增粘剂，增塑剂和药学上有效成分的贴剂，其中组合使用两种或更多种不同平均分子量的聚异丁烯，并且贴剂的粘合剂的粘度在 1500和30,000泊（60℃），贴片的粘性为5〜200g / 10mm。

    IONTOPHORESIS DEVICE
    83.
    发明公开
    IONTOPHORESIS DEVICE 审中-公开
    IONTOPHORESEGERÄT

    公开(公告)号：EP1230946A1

    公开(公告)日：2002-08-14

    申请号：EP00970090.7

    申请日：2000-10-26

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： INOUE, Kazutaka Tsukuba Laboratory

    IPC分类号： A61N1/30

    CPC分类号： A61N1/30

    摘要： This is an iontophoresis device preferred to detect abnormal conductivity at the beginning of energization and during energization. The iontophoresis device has a device (50) as a power source and the device (50) comprises an electric energy generating portion (60) generating electric energy, an output portion (70) outputting the electric energy, and an abnormal conductivity detecting portion (80) detecting whether or not the electric energy is supplied normally. The detecting action of the abnormal conductivity detecting portion (80) is carried out at the time of the non-output action of the output portion (70). During the energization, the output action by the output portion (70) and the detecting action by the abnormal conductivity detecting portion (80) are alternated in response to a command received from the microcomputer (12).

    摘要翻译： 这是一种离子渗透装置，优选在通电开始时和通电期间检测异常电导率。 离子电渗装置具有作为电源的装置（50），并且装置（50）包括产生电能的电能产生部（60），输出电能的输出部（70）和异常电导率检测部（ 80）检测电能是否正常供电。 异常电导率检测部（80）的检测动作在输出部（70）的非输出动作时进行。 在通电期间，响应于从微型计算机（12）接收的命令，输出部分（70）的输出动作和异常电导率检测部分（80）的检测动作交替。

    PERCUTANEOUS ADMINISTRATION PATCH MEDICINE
    87.
    发明授权
    PERCUTANEOUS ADMINISTRATION PATCH MEDICINE 失效
    铺平了透皮给药

    公开(公告)号：EP0734722B1

    公开(公告)日：2002-06-26

    申请号：EP94902115.8

    申请日：1993-12-14

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： YAMAGUCHI, Hisashi Tukuba Laboratory of Hisamitsu ,  MAEDA, Hiroyuki Tukuba Laboratory of Hisamitsu ,  KAMIHORIUCHI, Yoshirou Tukuba Laboratory of Hisam

    IPC分类号： A61K9/70

    CPC分类号： A61K9/703 ,  A61K9/7084

    摘要： A percutaneous administration patch medicine used to administer the medicine to a human body through the skin or mucous membrane, consisting of: (1) a backing layer nonpermeable to medicine components; (2) a medicine storage layer positioned on the lower side of the central portion of the backing layer and containing medicine components; (3) a protective film positioned on the lower side of the medicine storage layer and the circumferential portion of the backing layer, having cuts and nonpermeable to the medicine components; (4) a pressure sensitive adhesive layer positioned on the lower side of the protective film; and (5) a separable liner layer positioned on the lower side of the pressure sensitive adhesive layer and nonpermeable to the medicine components; the percutaneous administration patch medicine being capable of effectively minimizing the leakage and volatilization of medicine until the medicine has been administered to a patient through the skin, and maintaining the stability of the medicine during the preservation thereof.

    Iontoporesis device
    89.
    发明公开
    Iontoporesis device 失效
    Vorrichtung zur Verabreichung von Medikamenten durch Iontophorese

    公开(公告)号：EP1195175A2

    公开(公告)日：2002-04-10

    申请号：EP01124758.2

    申请日：1994-06-23

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： Okabe, Keiichiroi ,  Hibi, Toyoji

    IPC分类号： A61N1/32

    CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

    摘要： To avoid a reduction of the conductivity in iontophoresis due to the electrical decomposition and the changes in chemical properties of the electrodes themselves, covering by an electrical insulator, and to prevent a drop in the transport rate due to ions freed from the electrode. Provision is made of an electrode structure provided integrally with a reversible electrode and an auxiliary electrode for regeneration of the same and a regeneration current conducting means for conducting a current for regeneration of the reversible electrode when the therapeutic current is off, or the invention is comprised of a reversible electrode and an ion exchange membrane difficult for ions freed from that electrode to penetrate.

    摘要翻译： 为了避免由于电分解引起的电离电导率的降低以及电极本身的化学性质的变化，由电绝缘体覆盖，并且防止由于离开电极的离子导致的输送速率的下降。 提供与可逆电极和用于再生可再生电极的辅助电极整体设置的电极结构，以及当治疗电流关闭时用于传导用于再生可逆电极的电流的再生电流传导装置，或者包括本发明 的可逆电极和离子电极难以渗透的离子交换膜。