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公开(公告)号：EP2115425A1
公开(公告)日：2009-11-11
申请号：EP08708723.5
申请日：2008-02-05
申请人： Glaxo Group Limited , Astech Projects Ltd , Boehringer Ingelheim International GmbH , Boehringer Ingelheim Pharma GmbH & Co. KG
发明人： HANSFORD, Christopher Ian , HARVEY, Dominic Ewan , KUMB, Willi Juergen , MORAN, Anthony Michael , ROBERTS, William Leroy
IPC分类号： G01N15/02
CPC分类号： G01N15/0255 , B01L99/00 , G01N2015/0261
摘要： One aspect of the invention provides an automated system for performing repeated testing using an impactor which comprises a cup manifold defining multiple impaction cups, an impactor head defining transfer passages, and a nozzle manifold which defines multiple nozzles and is disposable between the cup manifold and the impactor head, so that in the assembled impactor a route is defined for through-flow via the impaction cups, the nozzles and the transfer passages. The system comprises an impaction station for performing impaction testing using the assembled impactor; a cup manifold recovery station for recovering sample material from the impactor cups in a solvent; an impactor head cleaning station; and at least one handling system for assembling the impactor for impaction, and for subsequently disassembling the impactor and delivering the cup manifold and the impactor head to their respective stations.
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82.发明公开PROCESS FOR THE SYNTHESIS OF DERIVATIVES OF 3-AMINO-TETRAHYDROFURAN-3-CARBOXYLIC ACID AND USE THEREOF AS MEDICAMENTS 审中-公开方法合成3-氨基 - 四氢呋喃-3-羧酸衍生物的和它们作为药物使用
公开(公告)号：EP2114909A2
公开(公告)日：2009-11-11
申请号：EP07866298.8
申请日：2007-12-21
发明人： HAN, Zhengxu , GERLACH, Kai , KRISHNAMURTHY, Dhileepkumar , MATTHES, Burkhard , NAR, Herbert , PRIEPKE, Henning , SCHULER-METZ, Annette , SENANAYAKE, Chris H. , SIEGER, Peter , TANG, Wenjun , WIENEN, Wolfgang , XU, Yibo , YEE, Nathan K.
IPC分类号： C07D307/24 , C07D409/14 , C07D413/14
CPC分类号： C07D409/14 , C07D307/24 , C07D413/14
摘要： The present invention relates to a process for the manufacturing of substituted 3- amino-tetrahydrofuran-3-carboxylic acid amides of general formula (I) and their precursors in high optical purity to the precursors of the synthesis of substituted S-Amino-tetrahydrofuran-S-carboxylic acid amides of general formula (I) in high optical purity, and to the tautomers, enantiomers, diastereomers, mixtures and salts of substituted 3-amino- tetrahydrofuran-3-carboxylic acid amides of general formula (I) in high optical purity, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
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83.发明公开Polymorphe von 3-[(2-{[4-(hexyloxycarbonylamino- imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsaeure-ethylester 审中-公开Polymorphe von 3 - [（2 - {[4-（己氧基羰基氨基 - 亚氨基 - 甲基） - 苯基氨基] - 甲基} -1-甲基-1-苯并咪唑-5-羰基） - 吡啶-2-基 - 氨基] 乙酯
公开(公告)号：EP2088146A3
公开(公告)日：2009-10-28
申请号：EP09157302.2
申请日：2006-06-01
发明人： Sieger, Peter , Hauel, Norbert , Schmid, Rolf , Sobotta, Rainer
IPC分类号： C07D401/12 , A61K31/4402 , A61K31/4184
CPC分类号： C07D401/12
摘要： Die Erfindung betrifft neue Polymorphe des Wirkstoffs 3-[(2-{[4-(Hexyloxycarbonyl-amino-imino-methyl)-phenylamino]-methyl}-1-methyl-1 H -benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester, deren Herstellung und deren Verwendung als Arzneimittel.
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84.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：EP2102170A2
公开(公告)日：2009-09-23
申请号：EP07864855.7
申请日：2007-11-29
IPC分类号： C07D231/56 , C07D401/14 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , A61K31/437 , A61K31/416 , A61P5/44 , A61P5/46
CPC分类号： C07D417/06 , C07D231/56 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D407/14 , C07D409/06 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
摘要： Compounds of Formula (IA), and Formula (IB), wherein R1, R2, R3, A, B, C, D, E, G, X, Y, and Z are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R 1，R 2，R 3，A，B，C，D，E，G，X，Y和Z如本文所定义的式（IA）和式（IB）化合物或其互变异构体，前药，溶剂化物 或其盐; 含有这些化合物的药物组合物以及调节糖皮质激素受体功能的方法以及使用这些化合物治疗患者的糖皮质激素受体功能介导的疾病状态或病症或以炎症，变应原或增殖过程为特征的方法。
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85.发明公开SULFATED BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE RECEPTOR AFFINITY 有权具有混合血清素受体的亲和力苯并咪唑酮硫酸酯衍生物
公开(公告)号：EP2097389A1
公开(公告)日：2009-09-09
申请号：EP07857748.3
申请日：2007-12-18
发明人： VOLZ, Astrid , LOTZ, Ralf , FABIO, PALEARI
IPC分类号： C07D235/26 , A61K31/4184 , A61P15/00
CPC分类号： C07D235/26
摘要： The present invention pertains to compounds of general formula (I) wherein R1, R2, R3, and R4 denote hydrogen or sulfate monoester with the proviso that R1, R2, R3, and R4 cannot simultaneously represent hydrogen, processes for their preparation and their use as pharmaceuticals.
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公开(公告)号：EP2091518A1
公开(公告)日：2009-08-26
申请号：EP07822344.3
申请日：2007-11-08
发明人： SCHULTZ-FADEMRECHT, Torsten , ZIMONTKOWSKI, Sandra , GARIDEL, Patrick , KERN, Hans-Joachim , STEFFENS, Klaus-Jürgen
CPC分类号： A61K9/0075 , A61K9/1623 , B01J2/04
摘要： The invention relates to a method for preparing powder mixtures, one component consisting of spray-dried powder. The invention also relates to a method for coating spray-dried particles with nanoscale particles, a method for mixing spray-dried powder with microscale particles and a method for covering carrier substances with spray-dried particles.
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87.发明公开Pyrimidinderivate, Arzneimittel enthaltend diese Verbindungen, deren Verwendung und Verfahren zu ihrer Herstellung 有权嘧啶衍生物，包含这些化合物，它们的用途和它们的制备方法的药物
公开(公告)号：EP2090571A1
公开(公告)日：2009-08-19
申请号：EP08163784.5
申请日：2002-10-14
申请人： Boehringer Ingelheim Pharma GmbH & Co. KG , Boehringer Ingelheim Pharmaceuticals, Inc. , BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人： Dahmann, Georg , Himmelsbach, Frank , Wittneben, Helmut , Pautsch, Alexander , Prokopowicz, Anthony S. , Krist, Bernd , Schnapp, Gisela , Steegmaier, Martin , Lenter, Martin , Schoop, Andreas , Steurer, Steffen , Spevak, Walter
IPC分类号： C07D239/48 , C07D403/12 , C07D471/04 , C07D401/12 , C07D413/12 , A61K31/505 , A61K31/506 , A61P35/00 , C07D235/00 , C07D221/00
CPC分类号： C07D239/48 , C07D231/12 , C07D233/56 , C07D239/50 , C07D239/80 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10
摘要： Die vorliegende Erfindung betrifft trisubstituierte Pyrimidine der Formel (I)
worin
R a bis R e wie im Anspruch 1 definiert sind, welche zur Behandlung von Krankheiten, die durch exzessive oder anomale Zellproliferation charakterisiert sind, geeignet sind, deren Verwendung zur Herstellung eines Arzneimittels mit den vorstehend erwähnten Eigenschaften, und Verfahren zu ihrer Herstellung.摘要翻译： 本发明涉及三取代的式（I），其中R如权利要求1中限定的至R E，其适合于治疗疾病为特征的过度或异常细胞增殖的嘧啶，它们的使用用于制备具有所述的药物组合物 上述特征，以及它们的制备方法。
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88.发明公开
公开(公告)号：EP2085396A2
公开(公告)日：2009-08-05
申请号：EP09157096.0
申请日：2006-04-21
IPC分类号： C07D451/10 , A61K31/46 , A61P11/06
CPC分类号： C07D451/10
摘要： The invention relates to a new crystalline forms of tiotropium bromide, processes for preparing them and their use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
摘要翻译： 本发明涉及噻托溴铵的新结晶形式，其制备方法及其用于制备用于治疗呼吸道疾病，特别是用于治疗COPD（慢性阻塞性肺疾病）和哮喘的药物组合物的用途。
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89.发明公开
公开(公告)号：EP2083007A1
公开(公告)日：2009-07-29
申请号：EP09157299.0
申请日：2004-10-29
IPC分类号： C07D451/10 , A61K31/46 , A61P11/00
CPC分类号： C07D451/10
摘要： Die Erfindung betrifft neue Tiotropiumsalze, Verfahren zu deren Herstellung, diese enthaltende Arzneimittelformulierungen sowie deren Verwendung zur Herstellung eines Arzneimittels zur Behandlung von Atemwegserkrankungen, insbesondere zur Behandlung von COPD (chronic obstructive pulmonary disease = chronisch obstruktive Lungenerkrankung) und Asthma.
摘要翻译： 本发明涉及新的噻托铵盐，它们的制备方法，含有它们的其用于呼吸系统疾病，特别是用于治疗COPD（慢性阻塞性肺病=慢性阻塞性肺病）和哮喘的治疗的药物中的用途的药物制剂。
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公开(公告)号：EP2081905A2
公开(公告)日：2009-07-29
申请号：EP07813203.2
申请日：2007-07-23
发明人： BERRY, Angela , CIRILLO, Pier Francesco , HICKEY, Eugene Richard , RIETHER, Doris , THOMSON, David S. , ERMANN, Monika , JENKINS, James Edward , MUSHI, Innocent , TAYLOR, Malcolm , CHOWDHURY, Chandana , PALMER, Christopher Francis , BLUMIRE, Nigel
IPC分类号： C07D215/38 , C07D217/22 , C07D213/75 , C07D231/40 , C07D233/88 , C07D235/30 , C07D261/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D277/56 , C07D277/60 , C07D277/62 , C07D285/08
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
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