公开(公告)号：EP2467169A1

公开(公告)日：2012-06-27

申请号：EP10810675.8

申请日：2010-08-20

申请人： Gilead Biologics, Inc.

发明人： MARSHALL, Derek ,  SMITH, Victoria

IPC分类号： A61K49/00

CPC分类号： A61K49/0008 ,  A61K49/0047 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24

摘要： Disclosed herein are methods and compositions for preventing and treating pulmonary fibrotic disorders, and for reducing or reversing the symptoms of pulmonary fibrotic disorders, such as idiopathic pulmonary fibrosis. The compositions include inhibitors of the LOXL2 protein, and the methods include methods for making and using the inhibitors.

公开(公告)号：EP2426142A3

公开(公告)日：2012-06-13

申请号：EP11183725.8

申请日：2007-10-16

申请人： Genelux Corporation

发明人： Frentzen, Alexa ,  Chen, Nanhai ,  Zhang, Qian ,  Yu, Yong ,  Szalay, Aladar

IPC分类号： C07K14/54 ,  C07K14/715 ,  C12N7/04 ,  C12N15/863 ,  A61K35/76 ,  A61K39/39 ,  A61K48/00

CPC分类号： C12N7/00 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/7068 ,  A61K33/24 ,  A61K35/76 ,  A61K38/1709 ,  A61K38/1793 ,  A61K38/20 ,  A61K38/204 ,  A61K38/36 ,  A61K38/484 ,  A61K39/12 ,  A61K39/285 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K48/0058 ,  A61K49/0008 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0097 ,  A61K49/14 ,  A61K49/1896 ,  A61K2039/523 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K14/47 ,  C07K14/54 ,  C07K14/5412 ,  C07K14/7155 ,  C07K16/22 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/60 ,  C07K2319/61 ,  C07K2319/74 ,  C12N15/86 ,  C12N2710/14171 ,  C12N2710/24121 ,  C12N2710/24122 ,  C12N2710/24132 ,  C12N2710/24141 ,  C12N2710/24143 ,  C12N2710/24162 ,  C12Q1/04 ,  G01N33/574 ,  G01N33/585

摘要： Modified or attenuated viruses and methods for preparing the modified viruses and modulating attenuation are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The viruses also can be used in diagnostic methods.

公开(公告)号：EP2130837A4

公开(公告)日：2010-08-04

申请号：EP08738644

申请日：2008-03-06

申请人： JAPAN GOVERNMENT

发明人： ISHIZAKA YUKIHITO ,  HASEGAWA MASAKATSU ,  NOHARA SATOSHI

IPC分类号： C07K7/08 ,  A61K41/00 ,  A61K47/48 ,  C07K7/06 ,  C07K9/00 ,  C07K14/16

CPC分类号： C07K14/005 ,  A61K47/64 ,  A61K49/0047 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/14 ,  A61K49/1863 ,  A61K49/1869 ,  B82Y5/00 ,  C07K7/08 ,  C07K2319/10 ,  C12N15/87 ,  C12N2740/16322

公开(公告)号：EP2167956A4

公开(公告)日：2010-07-14

申请号：EP08741964

申请日：2008-05-02

申请人： AGENCY SCIENCE TECH & RES

发明人： ZHUO LANG ,  HO GIDEON ,  KUMAR SARAVANA

IPC分类号： G01N33/48 ,  A61K49/00 ,  C12N15/85

CPC分类号： A61K49/0008 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0393 ,  A61K49/0047 ,  C12N15/8509 ,  G01N2800/164

公开(公告)号：EP1914316B1

公开(公告)日：2009-12-16

申请号：EP07018460.1

申请日：2002-07-31

申请人： Genelux Corporation

发明人： Szalay, Aladar A. ,  Yu, Yong A. ,  Shabahang, Shahrokh ,  Timirysova, Tatyana

IPC分类号： C12Q1/66 ,  C12Q1/02 ,  A61K49/00 ,  C12N15/03

CPC分类号： G01N33/574 ,  A61K47/6901 ,  A61K49/0013 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0097 ,  G01N2333/07

公开(公告)号：EP2097517A2

公开(公告)日：2009-09-09

申请号：EP07872632.0

申请日：2007-10-16

申请人： Genelux Corporation

发明人： FRENTZEN, Alexa ,  CHEN, Nanhai ,  ZHANG, Qian ,  YU, Yong, A. ,  SZALAY, Aladar, A.

IPC分类号： C12N7/04 ,  C12N15/863 ,  C07K14/07 ,  A61K35/76 ,  A61K39/285 ,  A61K48/00

CPC分类号： C12N7/00 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/7068 ,  A61K33/24 ,  A61K35/76 ,  A61K38/1709 ,  A61K38/1793 ,  A61K38/20 ,  A61K38/204 ,  A61K38/36 ,  A61K38/484 ,  A61K39/12 ,  A61K39/285 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K48/0058 ,  A61K49/0008 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0097 ,  A61K49/14 ,  A61K49/1896 ,  A61K2039/523 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K14/47 ,  C07K14/54 ,  C07K14/5412 ,  C07K14/7155 ,  C07K16/22 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/60 ,  C07K2319/61 ,  C07K2319/74 ,  C12N15/86 ,  C12N2710/14171 ,  C12N2710/24121 ,  C12N2710/24122 ,  C12N2710/24132 ,  C12N2710/24141 ,  C12N2710/24143 ,  C12N2710/24162 ,  C12Q1/04 ,  G01N33/574 ,  G01N33/585

摘要： Modified or attenuated viruses and methods for preparing the modified viruses and modulating attenuation are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The viruses also can be used in diagnostic methods.

公开(公告)号：EP2049686A2

公开(公告)日：2009-04-22

申请号：EP07800086.6

申请日：2007-08-10

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  UNIVERSITY OF CHICAGO

发明人： POPKO, Brian ,  BALABANOV, Roumen ,  WATKINS, Trent

IPC分类号： C12Q1/68

CPC分类号： G01N33/56966 ,  A61K49/0008 ,  A61K49/0045 ,  A61K49/0047 ,  G01N33/5058

摘要： The invention relates to the generation of an animal model that exhibits neural cell-specific expression of a marker gene that correlates to remyelination or myelin repair. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders, particularly in identifying compounds that promote or inhibit remyelination.

公开(公告)号：EP1795604A4

公开(公告)日：2008-08-27

申请号：EP05790164

申请日：2005-09-28

申请人： ONCOLYS BIOPHARMA INC

发明人： FUJIWARA TOSHIYOSHI ,  TANAKA NORIAKI ,  KYO SATORU ,  MIZUGUCHI HIROYUKI ,  HAYAKAWA TAKAO

IPC分类号： A61K49/00 ,  A61K35/76 ,  C07K14/47 ,  C07K14/705 ,  G01N33/576

CPC分类号： C12N15/86 ,  A61K49/0047 ,  C07K14/4702 ,  C07K14/70575 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2840/203 ,  G01N33/574

摘要： It is intended to provide a regent for detecting cancer cells or diagnosing cancer. More specifically speaking, a reagent for detecting cancer cells containing a recombinant virus in which a replication cassette having a human telomerase promoter, E1A gene, IRES sequence and E1B gene in this order is integrated into the E1 region of the virus genome while a labeling cassette having a gene encoding a labeled protein and a promoter capable of regulating the expression of the gene is integrated into the E3 region of the virus genome.

公开(公告)号：EP1668120A4

公开(公告)日：2007-01-10

申请号：EP04816108

申请日：2004-08-17

申请人： UNIV NEW YORK

发明人： MERUELO DANIEL ,  TSENG JEN-CHIEH

IPC分类号： C12N15/09 ,  A61K20060101 ,  A61K48/00 ,  A61K49/00 ,  A61K51/00 ,  A61M36/14 ,  C12N7/00 ,  C12N15/63 ,  C12Q1/70

CPC分类号： A61K49/0047 ,  A61K47/6901 ,  A61K49/0013 ,  A61K49/0097 ,  C12N2770/32132 ,  C12N2770/36143

公开(公告)号：EP1668120A2

公开(公告)日：2006-06-14

申请号：EP04816108.7

申请日：2004-08-17

申请人： NEW YORK UNIVERSITY

发明人： MERUELO, Daniel ,  TSENG, Jen-Chieh

IPC分类号： C12N7/00 ,  C12N15/63 ,  A61K48/00

CPC分类号： A61K49/0047 ,  A61K47/6901 ,  A61K49/0013 ,  A61K49/0097 ,  C12N2770/32132 ,  C12N2770/36143

摘要： Disclosed herein are methods for identifying cancer cells and monitoring anticancer therapy in the body of a mammal by systemically delivering Sindbis viral vectors. The vector can specifically target and identify tumor cells in mice growing subcutaneously, intraperitoneally, intrapancreatically, or in the lungs. These findings demonstrate the remarkable specificity of the Sindbis vector system that is relatively safe and can specifically target tumor cells throughout the body via the bloodstream.