摘要:
The invention relates to novel acylamino-hydroxy-benzamides of formula (I), wherein R 1 is phenyl substituted by phenyl, phenoxy, phenylamino or heteroaryl, all optionally further substituted; bicyclic aryl, monocyclic heteroaryl substituted by optionally substituted phenyl, or bicyclic heteroaryl, R 2 is hydrogen or methyl, and R 3 and R 4 have the meanings indicated in the description. These compounds are useful for the treatment and/or prophylaxis of skeletal muscle atrophy, schizophrenia and Alzheimer's disease, and as cognitive enhancers.
摘要:
The present invention relates to amide compounds of formula I which are EP4 receptor antagonists and useful for treating chronic renal failure and/or diabetic nephropathy.
Ring D is a group of formula II;
V and W are CH; R 45 is -CH 2 -B 5 ; B 5 represents a bicyclic hetero ring which may be substituted with one or more groups selected from the group consisting of halogen and C 1-6 alkyl; R 46 is H, halogen, C 1-6 alkyl which may be substituted with one or more halogens, or -O-C 1-6 alkyl; -NR 1 -YR 2 - is -NH-CH 2 -; Ring E is cyclohexane-1,4-diyl; and -Z-R 3 is -CO 2 H.
摘要翻译:本发明涉及酰胺I哪些是EP4受体拮抗剂和用于治疗慢性肾功能衰竭和/或糖尿病性肾病是有用的化合物。 环D为式II基团的; V和W是CH; :R 45为-CH 2 -B 5; B 5 darstellt双环杂环可被选自卤素和C 1-6烷基中选择的一个或多个基团substituiertem; R 46是H,卤素,C 1-6烷基,可被一个或多个卤素取代,或-O-C 1-6烷基; -NR 1 -Y 2 - 为-NH-CH 2 - ; 环E为环己烷-1,4-二; 和-Z-R 3是CO 2 H.
摘要:
The present application relates to cannabinoid receptor ligands containing compounds of formula (I) wherein A, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要:
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要:
Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.