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    Analogs of SHK toxin and their uses in selective inhibition of KV1.3 potassium channels
    81.
    发明公开
    Analogs of SHK toxin and their uses in selective inhibition of KV1.3 potassium channels 有权
    Analoga von ShK-Toxin und dessen Verwendung bei der selektiven Inhibition von KV1.3-Kaliumkanälen

    公开(公告)号：EP2474316A1

    公开(公告)日：2012-07-11

    申请号：EP12152320.3

    申请日：2005-10-07

    申请人： The Regents of the University of California ,  Bachem Biosciences, Inc

    发明人： Chandy, K., George ,  Beeton, Christine ,  Pennington, Michael

    IPC分类号： A61K38/00

    CPC分类号： A61K38/1767 ,  A61K47/48038 ,  A61K47/48261 ,  A61K47/542 ,  A61K47/6415 ,  G01N33/68 ,  G01N2015/149

    摘要： Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety, etc.) that has an anionic charge. In some embodiments the chemical entity attached to the ShK toxin may comprise an amino acid residue. The ShK analogs may be administered to human or non-human animal subjects to cause inhibition of potassium channels or to otherwise treat diseases or disorders. In some embodiments, the chemical entity to which the ShK toxin is attached may be chosen to provide selective inhibition of certain potassium channels (e.g., Kv1.3 channels) over other potassium channels (e.g., Kv1.1 channels). In come embodiments, the chemical entity to which the ShK toxin is attached may include a fluorophore, thereby providing a fluorophore tagged ShK analog. Such fluorophore tagged ShK analogs may be used in flow cytometry alone, or in conjunction with class II tetramers that can detect autoreactive cells.

    摘要翻译： ShK毒素的类似物和使用这种ShK类似物的方法。 ShK类似物通常包含与具有阴离子电荷的化学实体（例如原子，分子，基团，残基，化合物，部分等）连接的ShK毒素。 在一些实施方案中，连接至ShK毒素的化学实体可以包含氨基酸残基。 可以向人类或非人类动物受试者施用ShK类似物以引起钾通道的抑制或以其它方式治疗疾病或病症。 在一些实施方案中，可以选择与其连接的ShK毒素的化学实体以提供对其它钾通道（例如，Kv1.1通道）的某些钾通道（例如，Kv1.3通道）的选择性抑制。 在实施方案中，ShK毒素所连接的化学实体可以包括荧光团，从而提供荧光标记的ShK类似物。 这种荧光标记的ShK类似物可以单独用于流式细胞术，或与可检测自身反应性细胞的II类四聚体结合使用。

    Device for selectively targeting cells within a three-dimensional specimen
    85.
    发明公开
    Device for selectively targeting cells within a three-dimensional specimen 审中-公开
    探测器中的Vorrichtung zur gezielten Bestimmung von Zellen在einer dreidimensionalen

    公开(公告)号：EP2363828A1

    公开(公告)日：2011-09-07

    申请号：EP11001625.0

    申请日：2001-10-24

    申请人： Cyntellect, Inc.

    发明人： Eisfeld, Timothy M. ,  Palsson, Bernhard O. ,  Koller, Manfred R.

    IPC分类号： G06K9/00 ,  G01N15/14

    CPC分类号： G06K9/00127 ,  A61N5/062 ,  A61N5/1069 ,  A61N2005/067 ,  G01N15/1468 ,  G01N15/1475 ,  G01N2015/1415 ,  G01N2015/144 ,  G01N2015/1443 ,  G01N2015/1445 ,  G01N2015/1452 ,  G01N2015/1472 ,  G01N2015/149

    摘要： The invention relates to an apparatus for electromagnetically affecting a particle of interest in a specimen, comprising (a) a stage capable of supporting the specimen; (b) a detector capable of resolving a particle of interest within the specimen, wherein the detector comprises a camera viewing a shallow focal planar region and wherein the focal planar region can be refocused on different sections of the specimen; or wherein the detector comprises a camera viewing a shallow depth of field and wherein the detector can be automatically refocused to obtain different sectional images of the specimen; (c) a means for locating the particle of interest in three dimensions; (d) a means for focusing electromagnetic radiation to a focal volume within the specimen; and (e) a means for adjusting the relative positions of the stage and electromagnetic radiation focusing means, thereby positioning the particle of interest within the focal volume.

    摘要翻译： 本发明涉及一种用于电磁影响样品中感兴趣的颗粒的装置，包括：（a）能够支撑样品的载物台; （b）能够在样本内分辨感兴趣的颗粒的检测器，其中所述检测器包括观察浅焦平面区域的相机，并且其中所述焦平面区域可以重新聚焦在所述样本的不同部分上; 或其中所述检测器包括观察浅景深的照相机，并且其中所述检测器可被自动重新聚焦以获得所述样本的不同截面图像; （c）用于在三维中定位感兴趣的颗粒的装置; （d）用于将电磁辐射聚焦到样本内的焦点体积的装置; 和（e）用于调整舞台和电磁辐射聚焦装置的相对位置的装置，从而将感兴趣的颗粒定位在聚焦体积内。