Abstract:
The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
Abstract:
The invention relates to a device for identifying rain on a pane (2). The device comprises a camera (1) and an electrically drivable film (3) that actively emits light (h). The emitted light (h) emerges as light sheet (s) from the film (3). The camera (1) and the film (3) are designed and arranged in such a way that the camera (1) can detect a signal from the light (h) or an imaging (i1, i2) of the light sheet (s) which is emitted by the film (3), impinges on the pane (2) and is reflected by the pane. In particular, in this case, the signal detected by the camera (1) or the light sheet(s) (i1, i2) correlate(s) with light which is emitted by the film (3) and reflected or scattered at the inner side (2.1) and/or outer side (2.2) of the pane and/or at a raindrop.
Abstract:
The present invention relates to a device (100) and a method for optically controlling a chemical reaction in a reaction chamber (149) comprising a reagent fluid (114). In a preferred embodiment, the chemical reaction comprises a nucleic acid sequencing on a wiregrid. Based on strong optical confinement of excitation light (110) and of cleavage light (112), the sequencing reaction can be read-out. Stepwise sequencing is achieved by using nucleotides with optically cleavable blocking moieties. After read-out the built in nucleotide is deblocked by cleavage light through the same substrate. This ensures that only bound nucleotides will be unblocked. In order to avoid overheating by cleavage light, the reagent fluid is circulated along the surface of the substrate (101).
Abstract:
An optical system includes a lens assembly and a light source. The lens assembly includes an optical lens positioned to transmit and refract light provided by the light source, and a lens holder coupled to the optical lens and maintaining a position of the optical lens relative to the light source. The optical lens is coupled to the lens holder with a bonding agent arranged in an interrupted configuration at positions proximate to a circumference of the optical lens. The light source provides light to the optical lens of the lens assembly. The light provided to the optical lens has an optical footprint that includes a plurality of high-intensity regions separated from one another by low-intensity regions and the bonding agent is positioned in a circumferential orientation relative to the light source such that the bonding agent is spaced apart from the high-intensity regions of the optical footprint of the light.
Abstract:
The present invention relates to a substrate inspecting apparatus which is capable of reducing an inspection time of a substrate having a plurality of inspection regions and improving convenience of a user. The substrate inspecting apparatus according to an embodiment of the present invention includes an inspection unit inspecting inspection regions of a substrate according to an inspection sequence to obtain image data of the inspection regions, a control unit comprising a plurality of data processing parts processing the image data of the inspection regions, which is transmitted by the inspection unit, and an optimization module optimizing the inspection sequence of the inspection regions and a data processing sequence of the data processing parts, and a user interface displaying an optimization-oriented information relating the inspection sequence and the data processing sequence optimized by the optimization module.
Abstract:
The invention relates to a device and to a method for detecting at least partially reflective surfaces. Said device comprises a detection surface and an illumination device which is designed to project a pattern by reflecting over the at least partially reflective surface to the detection surface.
Abstract:
An automatic analyzer which can reduce the effort necessary for conducting a test of limit of detection/limit of quantification properties and managing the test results is provided. Operation condition-setting means for conducting an evaluation test for at least one of a limit of detection and a limit of quantification for each measurement item, determination condition-setting means for setting a determination condition of the evaluation test, and a calculation unit for obtaining a measurement result of a dilution series containing different dilution concentrations by controlling the sample-dispensing mechanism, the reagent-dispensing mechanism and the measurement unit based on the set operation condition, and calculating a test result of the evaluation test from the measurement result of the dilution series based on the set determination condition are disposed.
Abstract:
A method and instrument for detecting the presence or absence of a target organism in a test sample is provided. The instrument includes a carousel, a light source, alight detector, and a control system. The carousel is configured to hold a plurality of test sample containers, with each container held by the carousel at a container position. Each of the containers holds an admixture of a test mixture inoculated with the test sample. The light detector is operable to detect light emitted by the light source that has passed through the test sample disposed within the test container. The control system includes a processor. The control system is adapted to produce information indicative of the presence or absence of the target organism in the test sample using signals produced by the light detector.