公开(公告)号：EP1098655A2

公开(公告)日：2001-05-16

申请号：EP99935846.8

申请日：1999-07-22

申请人： METABOLIX, INC.

发明人： MARTIN, David, P. ,  PEOPLES, Oliver, P. ,  WILLIAMS, Simon, F. ,  ZHONG, Luhua

IPC分类号： A61K31/765 ,  A61K31/19 ,  A23L1/30

CPC分类号： A61K31/765 ,  A23K20/105 ,  A23K50/10 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/00 ,  A61K31/19 ,  A23V2250/206 ,  A23V2250/21 ,  A23V2250/30

摘要： Nutritional or therapeutic compositions are provided for increasing ketone body levels in the blood of mammals by providing a source of ketone bodies in the form of linear or cyclic oligomers and/or derivatives of 3-hydroxyacids. The 3-hydroxyacid can be in the form of a linear oligomer of 3-hydroxyacids other than linear homo-oligomers of 3-hydroxybutyric acid if administered in combination with acetoacetate, cyclic oligomers of 3-hydroxyacids, esters of the linear or cyclic oligomers, esters of 3-hydroxyacids other than 3-hydroxybutyric acid, and combinations thereof. An oligomer generally refers to a polymer of three or more hydroxyacids. Preferred 3-hydroxyacids include 3-hydroxybutyrate, 3-hydroxyvalerate, 3-hydroxyhexanoate, and 3-hydroxyheptanoate. Oligomers of odd-carbon number 3-hydroxyacids such as 3-hydroxyvalerate have advantages since they have a higher energy content than oligomers of 3-hydroxyacids having an even-number of carbons. The cyclic oligomers have advantageous properties since they result in a sustained, and/or controlled, ketone blood level over a period of hours. The compositions can be administered orally, for example, as a nutritional or dietary supplement, or intravenously. Increasing blood ketone levels is useful for seizure control, metabolic disease control, reduction of protein catabolism, appetite suppression, parenteral nutrition, increasing cardiac efficiency, treatment of diabetes and insulin resistant states, and treatment of effects of neurodegenerative disorders and epilepsy.

公开(公告)号：EP1014998A4

公开(公告)日：2000-10-25

申请号：EP98933260

申请日：1998-07-08

申请人： LIFE MEDICAL SCIENCES INC

发明人： COHN DANIEL ,  STERN THEODOR ,  LEVI AVRAHAM

IPC分类号： A61K31/765 ,  A61L31/06 ,  A61P17/02 ,  A61P41/00 ,  C08G63/06 ,  C08G63/08 ,  C08G63/664 ,  C08G69/44 ,  C08L67/04

CPC分类号： C08G69/44 ,  A61L31/06 ,  C08G63/08 ,  C08G63/664 ,  C08L67/04 ,  C08L77/12

摘要： The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or preventing adhesion formation subsequent to medical procedures such as surgery, for producing surgical articles including stents and grafts, as coatings, sealants, lubricants, as transient barriers in the body, for materials which control the release of bioactive agents in the body, for wound and burn dressings and producing biodegradable articles, among numerous others.

公开(公告)号：EP0707483A4

公开(公告)日：2000-05-17

申请号：EP94920809

申请日：1994-06-23

申请人： MEDLOGIC GLOBAL CORP

发明人： TIGHE PATRICK J ,  BYRAM MICHAEL M ,  BARLEY LEONARD V JR ,  GREFF RICHARD J

IPC分类号： A61K31/78 ,  A61L26/00 ,  A61K31/765 ,  A61K31/48 ,  A61L15/00

CPC分类号： A61K31/78 ,  A61L26/0014 ,  Y10S514/928 ,  C08L35/04

摘要： A cyanoacrylate adhesive is applied onto intact surface skin areas prone to ulceration so as to inhibit formation of surface skin ulcers.

摘要翻译： 将氰基丙烯酸酯粘合剂施加到易于溃疡的表皮肤区域上，以抑制表面皮肤溃疡的形成。

公开(公告)号：EP0675713B1

公开(公告)日：2000-03-22

申请号：EP94903924.2

申请日：1993-12-28

申请人： LABORATOIRES DOLISOS

发明人： FRANCHIMONT, Paul ,  BASSLEER, Corine 39, quai de l'Ourthe ,  ANGENOT, Luc ,  TITS, Monique

IPC分类号： A61K31/35 ,  A61K31/765 ,  A61K35/78

CPC分类号： A61K31/765 ,  A61K31/35 ,  A61K31/353 ,  A61K36/185

摘要： The use of prodelphinidines to prepare drugs for treating joint diseases related to cartilage damage, especially osteoarthritis, is dislcosed.

公开(公告)号：EP0538313B1

公开(公告)日：1999-04-07

申请号：EP91912537.7

申请日：1991-06-25

申请人： INSITE VISION, INC.

发明人： CHANDRASEKARAN, Santosh, Kumar ,  REENTS, Margaret, J. ,  BABCOCK, John, C. ,  BOWMAN, Lyle, M. ,  ARCHIBALD, Roy, D. ,  ROBINSON, Joseph, R.

IPC分类号： A61F2/14 ,  A61K9/70 ,  A61K31/765 ,  A61K9/64 ,  A61K9/00

CPC分类号： A61K9/0034 ,  A61K9/0048 ,  A61K9/006 ,  A61K31/765 ,  A61K31/78 ,  A61K47/32 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/914 ,  Y10S514/944 ,  Y10S514/953 ,  Y10S514/954 ,  Y10S514/955

摘要： Lightly cross-linked polymer, of which at least about 60 % by weight of the polymer, has been prepared by suspension or emulsion polymerizing at least about 50 % by weight of a carboxyl-containing monoethylenically unsaturated monomer acrylic acid with from about 0.1 % to about 5 % by weight of a non-polyalkenyl polyether difunctional cross-linking agent having a dry particle size of not more than about 30 νm in equivalent spherical diameter, are formulated with water and at least one ophthalmic demulcent, or at least one ophthalmic demulcent and at least one ophthalmic vasoconstrictor, into aqueous suspensions in which the amount of polymer ranges from about 0.1 % to about 6.5 % by weight.

公开(公告)号：EP0601417A3

公开(公告)日：1998-07-01

申请号：EP93119098

申请日：1993-11-26

申请人： HOECHST AG

发明人： STAHL WILHELM DR ,  AHLERS MICHAEL DR ,  WALCH AXEL DR ,  BARTNIK ECKHART DR ,  KRETZSCHMAR GERHARD DR ,  GRABLEY SUSANNE DR ,  SCHLEYERBACH RUDOLF DR

IPC分类号： A61K31/715 ,  A61K31/765 ,  A61K31/785 ,  A61K31/80 ,  A61K47/48 ,  A61K49/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07H15/04 ,  C07H15/203 ,  C08B37/00 ,  C08G63/00 ,  C08G63/06 ,  C08G64/00 ,  C08G64/42 ,  C08G65/16 ,  C08G67/04 ,  C08G69/00 ,  C08G69/10 ,  C08G73/16 ,  A61K31/70 ,  C07H13/04 ,  G01N33/50

CPC分类号： C07H15/203 ,  A61K47/595 ,  A61K47/645 ,  C07H15/04

摘要： Die Erfindung betrifft physiologisch verträgliche und physiologisch abbaubarer Kohlenhydratrezeptorblocker auf Polymerbasis mit einem HLB*-Wert von 10 bis 20 enthaltend:
Kohlenhydratanteil - bifunktionellen Spacer - hydrophiles, biodegradables Polymer - Wirkungsverstärker, wobei der aus 1 bis 20 natürlich vorkommenden gleichen oder verschiedenen Monosaccharidbausteinen bestehende Kohlenhydratanteil via ein oder mehrere bifunktionelle Spacer, der ein natürliches oder synthetisches Molekül ist, an ein hydrophiles, biodegradabeles Polymer gekoppelt ist, wobei das Polymer seinerseits Träger ein oder mehrerer Spacer ist und das hydrophile, biodegradable Polymer außerdem mit dem Wirkungsverstärker verbunden ist, welcher ein Vernetzer, ein oder mehrere Gruppen mit hydrophoben, hydrophilen oder ionischen Eigenschaften oder ein Löslichkeitsverbesserer ist, ein Verfahren zur Herstellung sowie seine in vivo Verwendung für die Blockierung kohlenhydraterkennender Rezeptoren.
Der Kohlenhydratrezeptorblocker ruft in vivo weder in seiner Gesamtheit noch in Form von Abbauprodukten Unverträglichkeitsreaktion hervor.

公开(公告)号：EP0723440A4

公开(公告)日：1997-06-11

申请号：EP94931827

申请日：1994-10-12

申请人： CYTRX CORP

发明人： EMANUELE R MARTIN ,  ALLAUDEEN HAMEEDSULTHAN S ,  KOUSOULAS KONSTANTIN G

IPC分类号： A61K9/00 ,  A61K31/70 ,  A61K31/765 ,  A61K38/50 ,  A61K39/245 ,  A61K47/10 ,  A61K48/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P37/04 ,  A61K31/00

CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K38/50 ,  A61K39/12 ,  A61K39/245 ,  A61K47/10 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/57 ,  A61K2039/6093 ,  C12N2710/16634

公开(公告)号：EP0759301A2

公开(公告)日：1997-02-26

申请号：EP96111163.0

申请日：1996-07-11

申请人： MORRIS A. MANN ,  AUSIMONT S.p.A.

发明人： Mann, Morris A. ,  Pantini, Giovanni

IPC分类号： A61K31/765

CPC分类号： A61K9/0026 ,  A61K31/80

摘要： Use of perfluoropolyethers with non reactive terminals or compositions thereof for the prevention and/or the treatment of topical viral infections, in particular of Herpes Simplex I and II and of Herpes Zoster.

摘要翻译： 使用全氟聚醚的单纯疱疹的非反应端子或其组合物用于预防和/或局部病毒感染的治疗中，特别是I型和II带状疱疹和。

公开(公告)号：EP0570519A4

公开(公告)日：1996-02-21

申请号：EP92906893

申请日：1992-02-05

申请人： PRO NEURON INC

发明人： VON BORSTEL REID WARREN ,  BAMAT MICHAEL KEVIN ,  HILTBRAND BRADLEY MARK ,  BUTLER JAMES CHARLES

IPC分类号： A61K47/00 ,  A61K9/02 ,  A61K9/08 ,  A61K9/10 ,  A61K9/127 ,  A61K9/20 ,  A61K9/28 ,  A61K31/513 ,  A61K31/52 ,  A61K31/522 ,  A61K31/675 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/765 ,  A61K38/00 ,  A61K38/04 ,  A61K38/16 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K38/22 ,  A61K45/00 ,  A61K45/06 ,  A61K47/26 ,  A61K47/34 ,  A61P7/00 ,  A61P7/04 ,  A61P7/06 ,  A61P7/08 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/04 ,  A61P43/00 ,  C07D473/00 ,  C07D473/04 ,  C07D473/06 ,  C07D473/18 ,  C07D473/26 ,  C07D473/30 ,  C07H19/16 ,  C07H19/167 ,  C07H19/173 ,  A61K39/39 ,  C11D1/66

CPC分类号： A61K31/70 ,  A61K31/52 ,  A61K31/765 ,  A61K38/1816 ,  A61K38/193 ,  A61K38/20 ,  A61K45/06 ,  C07D473/00 ,  C07H19/16 ,  A61K2300/00

公开(公告)号：EP0538313A4

公开(公告)日：1994-04-13

申请号：EP91912537

申请日：1991-06-25

申请人： INSITE VISION, INC.

发明人： CHANDRASEKARAN, SANTOSH, KUMAR ,  REENTS, MARGARET, J. ,  BABCOCK, JOHN, C. ,  BOWMAN, LYLE, M. ,  ARCHIBALD, ROY, D. ,  ROBINSON, JOSEPH, R.

IPC分类号： A61F2/14 ,  A61K8/81 ,  A61K9/00 ,  A61K9/10 ,  A61K9/107 ,  A61K31/765 ,  A61K31/78 ,  A61K47/30 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61Q11/00 ,  A61Q19/00

CPC分类号： A61K9/0034 ,  A61K9/0048 ,  A61K9/006 ,  A61K31/765 ,  A61K31/78 ,  A61K47/32 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/914 ,  Y10S514/944 ,  Y10S514/953 ,  Y10S514/954 ,  Y10S514/955

摘要： Lightly cross-linked polymer, of which at least about 60 % by weight of the polymer, has been prepared by suspension or emulsion polymerizing at least about 50 % by weight of a carboxyl-containing monoethylenically unsaturated monomer acrylic acid with from about 0.1 % to about 5 % by weight of a non-polyalkenyl polyether difunctional cross-linking agent having a dry particle size of not more than about 30 νm in equivalent spherical diameter, are formulated with water and at least one ophthalmic demulcent, or at least one ophthalmic demulcent and at least one ophthalmic vasoconstrictor, into aqueous suspensions in which the amount of polymer ranges from about 0.1 % to about 6.5 % by weight.

摘要翻译： 轻度交联的聚合物，其中至少约60重量％的聚合物已通过悬浮或乳液聚合至少约50重量％的含羧基的单烯键式不饱和单体丙烯酸制备，其含量为约0.1重量％至 约5重量％的具有等效球体直径的干粒径不超过约30nm的非聚链烯基聚醚双官能交联剂与水和至少一种眼用缓冲剂或至少一种眼用缓和剂 和至少一种眼用血管收缩剂混合成含水悬浮液，其中聚合物的量为约0.1重量％至约6.5重量％。