摘要:
Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.
摘要:
The present invention provides a model that can be use to describe biological processes having a complex spatial geometry, for example, cell signaling processes. The models can also be used to model the pathology underlying diseases characterized by disrupted signaling pathways, and to identify target proteins at an appropriate site in a signal transduction network such that modulation of the target proteins elicits therapeutic effects. Methods of modeling diffusion processes, as well as machine-readable products embodying the methods are also disclosed.
摘要:
A computer assisted knee replacement apparatus and method comprises a total knee replacement application for assisting, guiding, and planning a total knee replacement procedure (40, 12, 22, 28, 18 and 16). The apparatus and method cooperates with a tracking system to determine implant sizing and location. The apparatus and method also cooperates with the tracking system to determine implant size and location. The apparatus and method also cooperates with the tracking system to determine required tibial and femoral preparation corresponding to the implant size and location and provides real-time monitoring of the tibial and femoral surface preparation procedures.
摘要:
A data structure with associated algorithms for representing and reconstructing contaminant transport in realistic complex geometries, e.g. in cities and around buildings, is described (160). The data structure has a pair of two-dimensional matrices compressed and extracted from three-dimensional matrices describing the transport and dispersion of contaminants in complex geometries using full-resolution, time-dependent computational fluid dynamics or compete and detailed experimental data (130). A first matrix (220, 320) has numerical values, in which continuous, monotone, gauge-invariant contours of the same value represent an edge of a family of contaminant clouds transported from one edge of the domain. A second matrix (250, 350) contains numerical values, in which continuous, monotone, gauge-invariant contours of the same value represent an opposite edge of a family of contaminant clouds transported from the other edge of the domain. The dual-matrix data structure may be used by overlapping the two matrices (440, 480) within the domain, and reading the areas between the two edge contours crossing at particular locations of interest.
摘要:
A method and system of transforming a product development process to reduce time in bringing a product to market through high throughput experimentation and advanced statistics and informatics, to transform the product development to a level of higher correlation with engine tests, and to develop better commercial products. This is achieved by modeling in Silico a plurality of component molecular models; deriving in Silico molecular characteristics (descriptors) for each of the plurality of compiled molecular models; creating at least one combinatorial library database record for each of the formulations, the at least one record having a plurality fields for storing information about compositional characteristics; receiving specification requirements for a lubricating oil composition; selecting from a database entries corresponding to compositions having specifications comparable to the received specification requirements; formulating a new lubricating oil composition to comply with received specification requirements; testing the new lubricant oil for compliance with received specification requirements; repeating the selecting, formulating, and testing steps until compliance with received specification requirements is achieved; and correlating the new lubricating oil composition to actual engine performance.
摘要:
The invention relates to numerical simulation of subsurface geological reservoirs (60). More specifically embodiments of the invention are related to computer modeling of the transmission properties, for example the flow of fluids (30, 39, 38)(e.g. hydrocarbon natural resources and water), within subsurface geological reservoirs (60). One embodiment of the invention includes a method of evaluating the transmission property within a subsurface geologic reservir (60) using a graph-theory single source shortest path algorithm (54).
摘要:
A multi-scale finite-volume (MSFV) method to solve elliptic problems with a plurality of spatial scales arising from single or multi-phase flows in porous media is provided. Two sets of locally computed basis functions are employed. A first set of basis functions captures the small-scale heterogeneity of the underlying permeability field, and it is computed to construct the effective coarse-scale transmissibilities. A second set of bases functions is required to construct a conservative fine-scale velocity field. The method efficiently captures the effects of small scales on a coarse grid, is conservative, and treats tensor permeabilities correctly. The underlying idea is to construct transmissibilities that capture the local properties of a differential operator. This leads to a multi-point discretization scheme for a finite-volume solution algorithm. Transmissibilities for the MSFV method are preferably constructed only once as a preprocessing step and can be computed locally. Therefore, this step is well suited for massively parallel computers. Furthermore, a conservative fine-scale velocity field can be constructed from a coarse-scale pressure solution which also satisfies the proper mass balance on the fine scale. A transport problem is ideally solved iteractively in two stages. In the first stage, a fine scale velocity field is obtained from solving a pressure equation. In the second stage, the transport problem is solved on the fine cells using the fine-scale velocity field. A solution may be computed on the coarse cells at an incremental time and properties, such as a mobility coefficient, may be generated for the fine cells at the incremental time. If a predetermined condition is not met for all fine cells inside a dual coarse control volume, then the dual and fine scale basis functions in that dual coarse control volume are reconstructed.
摘要:
A mill roll analysis system is described that includes a user interface module, a structural analysis engine, and an analysis control script (22). The user interface module receives mill roll design data from a remote user via a computer network (9). The analysis control script automatically directs the structural analysis engine to define and evaluate an appropriate analytical model for the mill roll design based on the mill roll design data (4). The mill roll analysis system presents an intuitive web-based interface for capturing the mill roll design data, and may present predefined mill roll applications and mill roll types for selection for the user. As a result, the remote user need not be familiar with the underlying analytical modeling techniques, which may be highly-complex by nature. Consequently, a user may utilize the system to evaluate and improve mill roll design in order to achieve increased product performance.
摘要:
A method for determining dosages received by a product to be exposed to a treatment source at least one defined location from the treatment source. One exemplary method includes defining a point on the product (Fig.3, item 138). Then, fixed zones and variable zones are defined. Next, pre-calculated lengths between the point on the product and the treatment source are identified at each of the at least one defined location (Fig.4, item 158) Then, a dosage of treatment to be received by the point on the product at each of the at least one defined location is calculated (Fig.4, item 160), wherein the calculation uses the pre-calculated lengths. An apparatus for exposing a product to a treatment and a treatment system are also provided.
摘要:
The invention relates to a computer system and method for simulating transport phenomena in a complex system. The computer system comprises a logic interface that enables a user of the computer system to dynamically construct logic to customize simulation of the physical system, a means for converting the constructed logic into corresponding object-oriented code, a means for integrating the object-oriented code with the main simulation system which comprises a simulation data model and simulation algorithms, resulting in an integrated simulation system, and a means for executing the integrated simulation system.