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公开(公告)号：EP1377574A1
公开(公告)日：2004-01-07
申请号：EP02722110.0
申请日：2002-02-21
发明人： FLOCKERZI, Dieter , GUTTERER, Beate , GRUNDLER, Gerhard , HATZELMANN, Armin , BEUME, Rolf , BUNDSCHUH, Daniela , KLEY, Hans-Peter , NAVE, Rüdiger , ZECH, Karl , REUTTER, Felix
IPC分类号： C07D471/04 , A61K31/47 , A61P11/16
CPC分类号： C07D471/04 , A61K31/47 , Y02A50/409 , Y02A50/411
摘要： Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in the description, are novel effective PDE3/4 Inhibitors.
摘要翻译： 其中R 1，R 2，R 3，R 4和R 5具有说明书中所示含义的式（I）化合物是新型有效的PDE3 / 4抑制剂。
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公开(公告)号：EP1368317A1
公开(公告)日：2003-12-10
申请号：EP02722097.9
申请日：2002-02-19
发明人： MARTIN, Thomas , BÄR, Thomas , STADLWIESER, Josef , ULRICH, Wolf-Rüdiger , DOMINIK, Andreas , BUNDSCHUH, Daniela , ZECH, Karl , SOMMERHOFF, Christian, P.
IPC分类号： C07D213/30 , A61K31/44 , A61P11/00
CPC分类号： C07D213/30
摘要： Compounds of the formula (I), in which M is a central building block selected from the group below in which A1, A2, K1 and K2 are as defined in the description, are novel effective tryptase inhibitors.
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公开(公告)号：EP1303506A1
公开(公告)日：2003-04-23
申请号：EP01962844.5
申请日：2001-07-07
发明人： BUNDSCHUH, Daniela , FLOCKERZI, Dieter , GRUNDLER, Gerhard , HATZELMANN, Armin , KLEY, Hans-Peter , WEINBRENNER, Steffen , GUTTERER, Beate
IPC分类号： C07D401/04 , A61K31/473 , A61P11/06 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
CPC分类号： C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of the formula I, in which Het is an unsubstituted or R6-and/or R7-sustituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrimidinyl, pyrazinyl or pyridazinyl radical, or an unsubstituted or R6-and/or R7-substituted fused bi-or tricyclic ring system comprising at least one aromatic ring and up to 4 heteroatoms-selected from the group consisting of O(oxygen), S(sulphur) or N(nitrogen)-which is bonded to the phenanthridinyl radical via one of the rings comprising one or more heteroatoms, areactive PDE4 inhibitors.
摘要翻译： 其中Het为未取代或R6-和/或R7-取代的吡咯基，呋喃基，噻吩基，吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，噻二唑基，嘧啶基，吡嗪基或哒嗪基的式I化合物， （氧），S（硫）或N（氮） - 的至少一个芳族环和至多4个杂原子的未取代或R 6 - 和/或R 7 - 取代的稠合双或三环环系统 - 其通过包含一个或多个杂原子的区域性PDE4抑制剂中的一个环与菲啶基结合。
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公开(公告)号：EP1228046A1
公开(公告)日：2002-08-07
申请号：EP00977430.8
申请日：2000-10-24
发明人： HATZELMANN, Armin , BUNDSCHUH, Daniela , KLEY, Hans-Peter , VAN DER LAAN, Johanna , TIMMERMANN, Hendrik , STERK, Jan, Geert
IPC分类号： C07D237/32 , A61K31/502 , A61P11/06 , C07D405/04
CPC分类号： C07D405/04 , C07D237/32 , C07D417/10
摘要： The compounds of formula (I) in which R1, R2, A, B and Ar have the meanings as given in the description are novel effective PDe4 inhibitors.
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公开(公告)号：EP1192184A1
公开(公告)日：2002-04-03
申请号：EP00935162.8
申请日：2000-06-02
IPC分类号： C07K14/785 , A61K38/17 , A61P11/00
CPC分类号： C07K14/785 , A61K38/00
摘要： Novel surfactant protein C esters suitable for preparing pharmaceutical compositions for the treatment of infant respiratory distress syndrome and adult respiratory distress syndrome are described.
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6.发明公开3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXY-N-(3,5-DICHLOROPYRID-4-YL)BENZAMIDE IN THE TREATMENT OF MULTIPLE SCLEROSIS 有权3-环丙基甲氧基-4-二氟甲氧基-N-（3,5-二氯吡啶-4-基） - 苯甲酰胺用于治疗多发性硬化
公开(公告)号：EP1161239A2
公开(公告)日：2001-12-12
申请号：EP00910736.8
申请日：2000-03-01
IPC分类号： A61K31/44 , A61K31/4412 , A61P25/00
CPC分类号： A61K31/4412 , A61K31/44 , Y10S514/903
摘要： The invention relates to the novel use of 3-cyclopropylmethoxy-4-difluoromethoxy-N-(3,5-dichloropyrid-4-yl)benzamide, a pharmacologically tolerable salt thereof or its N-oxide in the treatment of multiple sclerosis.
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公开(公告)号：EP1147089A1
公开(公告)日：2001-10-24
申请号：EP00901534.8
申请日：2000-01-12
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann DI , GRUNDLER, Gerhard , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , C07D401/10 , A61P11/08
CPC分类号： C07D401/12 , C07D221/12 , C07D401/10
摘要： Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 has the meanings indicated in the description, are novel active bronchial therapeutics.
摘要翻译： 其中R 1，R 2，R 3，R 31，R 4，R 5，R 51，R 6，R 13和R 20具有说明书中指出的含义的式（I）化合物为新的活性支气管疗法。
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公开(公告)号：EP1127059A1
公开(公告)日：2001-08-29
申请号：EP99953956.2
申请日：1999-10-29
发明人： GRUNDLER, Gerhard , POSTIUS, Stefan , SIMON, Wolfgang-Alexander , KROMER, Wolfgang , SENN-BILFINGER, Jörg
IPC分类号： C07D471/14 , A61K31/44
CPC分类号： C07D471/14
摘要： Compounds of formula (I), in which the substituents are as defined in the description are suitable for preventing and treating gastrointestinal disorders.
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公开(公告)号：EP1115731A2
公开(公告)日：2001-07-18
申请号：EP99942928.5
申请日：1999-08-27
发明人： STADLWIESER, Josef , ULRICH, Wolf-Rüdiger , DOMINIK, Andreas , BUNDSCHUH, Daniela , ELTZE, Manfrid , ZECH, Karl , SOMMERHOFF, Christian , MARTIN, Thomas , BÄR, Thomas
IPC分类号： C07H1/00
CPC分类号： C07H13/12 , C07H15/203
摘要： The invention relates to compounds of formula (I), wherein M, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, B5, B6, K1 and K2 have the meanings given in the description. Said compounds are novel, effective tryptase inhibitors.
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公开(公告)号：EP1070056A1
公开(公告)日：2001-01-24
申请号：EP99914474.4
申请日：1999-03-04
发明人： HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , BEUME, Rolf , KLEY, Hans-Peter , VAN DER LAAN, Ivonne, Johanna , TIMMERMAN, Hendrik , STERK, Geert, Jan , VAN DER MEY, Margaretha
IPC分类号： C07D237/32 , A61K31/50 , C07D417/12 , A61K31/54
CPC分类号： C07D237/32 , C07D417/12
摘要： The compounds of formula (I) in which R1, R2, R3, R4, R5, X and Y have the meanings as given in the description are novel effective bronchial therapeutica.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，X和Y具有如在说明书中给出的含义的式（I）化合物是新型有效的支气管疗法。
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