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公开(公告)号：EP1147089A1
公开(公告)日：2001-10-24
申请号：EP00901534.8
申请日：2000-01-12
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann DI , GRUNDLER, Gerhard , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , C07D401/10 , A61P11/08
CPC分类号： C07D401/12 , C07D221/12 , C07D401/10
摘要： Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 has the meanings indicated in the description, are novel active bronchial therapeutics.
摘要翻译： 其中R 1，R 2，R 3，R 31，R 4，R 5，R 51，R 6，R 13和R 20具有说明书中指出的含义的式（I）化合物为新的活性支气管疗法。
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公开(公告)号：EP1070056A1
公开(公告)日：2001-01-24
申请号：EP99914474.4
申请日：1999-03-04
发明人： HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , BEUME, Rolf , KLEY, Hans-Peter , VAN DER LAAN, Ivonne, Johanna , TIMMERMAN, Hendrik , STERK, Geert, Jan , VAN DER MEY, Margaretha
IPC分类号： C07D237/32 , A61K31/50 , C07D417/12 , A61K31/54
CPC分类号： C07D237/32 , C07D417/12
摘要： The compounds of formula (I) in which R1, R2, R3, R4, R5, X and Y have the meanings as given in the description are novel effective bronchial therapeutica.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，X和Y具有如在说明书中给出的含义的式（I）化合物是新型有效的支气管疗法。
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公开(公告)号：EP0988302A1
公开(公告)日：2000-03-29
申请号：EP98930737.6
申请日：1998-05-27
发明人： GUTTERER, Beate , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , BEUME, Rolf , HÄFNER, Dietrich , BÄR, Thomas , MARTIN, Thomas , KILIAN, Ulrich , ELTZE, Manfrid , BRAND, Ursula , BOSS, Hildegard , KLEY, Hans-Peter , SCHUDT, Christian , GOEBEL, Karl-Josef , FLOCKERZI, Dieter , HATZELMANN, Armin
IPC分类号： C07D471/04 , A61K31/47
CPC分类号： C07D471/04
摘要： The invention concerns the compounds 8,9-Diethoxy-2-methyl-6- [4(p-toluenesulfonamido)phenyl] -1,2,3,4,4a,10b-hexahydrobenzo[c] [1,6]naphthyridine and 9-Ethoxy-8-methoxy-2- methyl-6-[4-(p-toluenesulfonamido) phenyl]-1,2,3,4,4a,10b-hexahydrobenzo [c][1,6]naphthyridine and their therapeutic application.
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公开(公告)号：EP0968211A1
公开(公告)日：2000-01-05
申请号：EP98913621.3
申请日：1998-03-03
发明人： GUTTERER, Beate , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger , MARTIN, Thomas , BÄR, Thomas , HUMMEL, Rolf-Peter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KLEY, Hans-Peter , HÄFNER, Dietrich , GOEBEL, Karl-Josef , FLOCKERZI, Dieter
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： Compounds of formula (I) in which R4 is a phenyl radical substituted by R5, where R5 is a tetrazole-5-yl radical optionally substituted by a radical R6, are novel efficacious PDE3/4 inhibitors.
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公开(公告)号：EP0863899A1
公开(公告)日：1998-09-16
申请号：EP96939829.0
申请日：1996-11-16
发明人： BÄR, Thomas , ZIMMERMANN, Peter , BOER, Rainer , GEKELER, Volker , ISE, Wolfgang , BOSS, Hildegard , ULRICH, Wolf-Rüdiger
CPC分类号： C07D471/04
摘要： The invention concerns compounds of formula (I) in which the substituents and symbols have the meanings given in the description. These compounds are advantageous resistance modulators.
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公开(公告)号：EP0506801A1
公开(公告)日：1992-10-07
申请号：EP91901780.0
申请日：1990-12-19
发明人： ULRICH, Wolf-Rüdiger , ZIMMERMANN, Peter , KLEMM, Kurt , SANDERS, Karl , BOER, Rainer , BELLER, Klaus-Dieter , BOSS, Hildegard
CPC分类号： C07D211/90
摘要： Les dihydropyridines de formule (I), dans laquelle les substituants et les symboles ont la signification indiquée dans la description, sont de nouvelles substances possédant des propriétés pharmacologiques intéressantes.
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公开(公告)号：EP1147087A1
公开(公告)日：2001-10-24
申请号：EP00901089.3
申请日：2000-01-12
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann DI , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , A61P11/08
CPC分类号： C07D221/12
摘要： The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics.
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8.发明公开BENZAMIDE MIT TETRAHYDROFURANYLOXY-SUBSTITUENTEN ALS INHIBITOREN DER PHOSPHODIESTERASE 4 有权与四氢呋喃氧基取代基苯甲酰作为抑制剂磷酸二酯酶4
公开(公告)号：EP1086096A1
公开(公告)日：2001-03-28
申请号：EP99926441.9
申请日：1999-05-27
发明人： MARTIN, Thomas , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , GUTTERER, Beate , FLOCKERZI, Dieter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KILIAN, Ulrich , KLEY, Hans-Peter , BÄR, Thomas
IPC分类号： C07D405/12 , A61K31/44 , A61K31/34 , A61K31/35 , C07D493/10 , C07D307/20 , C07D309/10
CPC分类号： C07D405/12 , C07D493/10
摘要： Compounds of formula (I), wherein R1, R2, R3, R4, R5, m and n have the meanings cited in the description, are novel and effective PDE inhibitors.
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公开(公告)号：EP1075476A1
公开(公告)日：2001-02-14
申请号：EP99920814.3
申请日：1999-04-29
发明人： MARTIN, Thomas , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , GUTTERER, Beate , FLOCKERZI, Dieter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KILIAN, Ulrich , KLEY, Hans-Peter , BÄR, Thomas
IPC分类号： C07D413/00 , A61K31/42 , A61K31/415 , C07D405/04 , C07D413/04 , C07D413/14
CPC分类号： C07D405/04 , C07D413/04 , C07D413/14
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and Y have the meanings given in the description. Said compounds are novel active bronchial therapeutic agents.
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公开(公告)号：EP0920426A1
公开(公告)日：1999-06-09
申请号：EP97940080.0
申请日：1997-08-13
发明人： AMSCHLER, Hermann , MARTIN, Thomas , FLOCKERZI, Dieter , GUTTERER, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , BEUME, Rolf , BÄR, Thomas , ULRICH, Wolf-Rüdiger
CPC分类号： C07D417/04 , C07D417/14
摘要： Compounds having the formula (I), in which R1, R2, R3, R4 and n have the meanings given in the description, are new effective bronchotherapeutic agents (phosphodiesterase IV inhibitors).
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