公开(公告)号：EP1842228A4

公开(公告)日：2010-03-10

申请号：EP06717860

申请日：2006-01-10

申请人： BIOFORCE NANOSCIENCES INC

发明人： HENDERSON ERIC R ,  MOSHER CURTIS L

IPC分类号： H01L21/302 ,  C12M1/00 ,  G01N15/06

CPC分类号： G03F7/0002 ,  B82Y10/00 ,  B82Y40/00

公开(公告)号：EP1583845A2

公开(公告)日：2005-10-12

申请号：EP03800411.5

申请日：2003-12-30

申请人： Bioforce Nanosciences, Inc.

发明人： HENDERSON, Eric ,  MOSHER, Curtis ,  HUFF, Janice

IPC分类号： C12Q1/68

CPC分类号： G01N33/54373 ,  B01J2219/00387 ,  B01J2219/00605 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N2035/00158 ,  G01Q60/42

摘要： The interrogation of extremely small sample volumes can be accomplished with the present invention. Provided are probes having disposed thereon a plurality of domains forming an array, which is suitably a nanoarray. Also provided are methods of detecting molecules and molecular interaction events, retrieving and analyzing analytes, and delivering substances to cells or tissues using probes of the invention.

公开(公告)号：EP1348113B1

公开(公告)日：2008-07-30

申请号：EP01993149.2

申请日：2001-08-14

申请人： Bioforce Nanosciences, Inc.

发明人： HENDERSON, Eric ,  MOSHER, Curtis

IPC分类号： B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  G01N1/14 ,  G01N15/06 ,  G01N33/543 ,  C12N11/16 ,  C12M1/36

CPC分类号： B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00698 ,  B01J2219/00704 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01L3/0244 ,  B82B3/00 ,  C40B40/06 ,  C40B50/14 ,  Y10S977/924

摘要： The present invention is a dedicated apparatus for the formation of array that includes one or more deposition domains comprised of one or more deposition materials. The present invention may include an X, Y controller, an X, Y translation stage, a loading substrate, a deposition substrate, a Z controller, and a deposition probe. A computer controls all of the relative positions of each of the components. Furthermore, the present invention utilizes a humidity control system to create a capillary bridge between the probe and the substrate for transferring the deposition material between the loading substrate, the deposition probe, and the deposition substrate.

公开(公告)号：EP1748846A2

公开(公告)日：2007-02-07

申请号：EP05779157.6

申请日：2005-04-29

申请人： Bioforce Nanosciences, Inc.

发明人： HENDERSON, Eric, R. ,  XU, Juntao ,  LYNCH, Michael, P. ,  MOSHER, Curtis, L. ,  HUFF, Janice, Lillian ,  NETTIKADAN, Saju, Rappai

IPC分类号： B01L3/02 ,  G01N1/10 ,  B05C5/00

CPC分类号： B01L3/0244 ,  B01J2219/00387 ,  B01J2219/00659 ,  B01L3/0248 ,  B01L2200/12 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/10 ,  B01L2400/02 ,  B01L2400/0406

摘要： Some embodiments of the present invention provide an apparatus and method in which material is deposited upon a surface from an elongated beam (102) having an aperture (104) defined therein through which the material is moved by passive adsorption. The elongated beam can be substantially planar along substantially its entire length, can be oriented at an acute angle with respect to the surface during deposition processes, and can have a length no greater than about 2mm. In some embodiments, the aperture can be elongated, can extend from a material reservoir (106) to a location short of the terminal end of the elongated beam or through the terminal end of the elongated beam, and can have a portion extending through the thickness of the elongated beam.

公开(公告)号：EP1330651A2

公开(公告)日：2003-07-30

申请号：EP01981445.8

申请日：2001-10-10

申请人： Bioforce Nanosciences, Inc.

发明人： HENDERSON, Eric ,  MOSHER, Curtis

IPC分类号： G01N33/543

CPC分类号： C07K16/065 ,  Y10S436/807

摘要： The present invention is a method for selectively removing objects from a surface utilizing a probe. The probe is scanned over the surface utilizing a greater and greater relative amount of force so that a certain number of the objects are removed from the surface. The force required to remove the objects from the surface can be calculated utilizing Hook's law and the spring constant of the probe. After removal of the objects that have a relatively weaker binding affinity with the surface, the remaining objects can be harvested, characterized, and subjected to further study.

公开(公告)号：EP1513954A4

公开(公告)日：2005-10-19

申请号：EP03734244

申请日：2003-05-29

申请人： BIOFORCE NANOSCIENCES INC

发明人： HENDERSON ERIC R ,  NETTIKADAN SAJU R ,  MOSHER CURTIS L

IPC分类号： B05D3/00 ,  C12Q1/02 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/552 ,  G01N33/553 ,  G01N33/554 ,  G01N33/569 ,  G01Q10/00 ,  G01Q30/20 ,  G01Q60/34 ,  G02B26/10 ,  G01N13/10 ,  G01N13/16

CPC分类号： G01N33/553 ,  G01N33/56983 ,  G01N2333/07 ,  Y10S977/853

摘要： The present invention includes a method and apparatus for the detection of a target material. The method and apparatus includes providing a substrate with a surface and forming a domains of deposited materials thereon. The deposited material can be placed on the surface and bound directly and non-specifically to the surface, or it may be specifically or non-specifically bound to the surface. The deposited material has an affinity for a specific target material. The domains thus created are termed affinity domains or deposition domains. Multiple affinity domains of deposited materials can be deposited on a single surface, creating a plurality of specific binding affinity domains for a plurality of target materials. Target materials may include, for example, pathogens or pathogenic markers such as viruses, bacteria, bacterial spores, parasites, prions, fungi, mold or pollen spores. The device thus created is incubated with a test solution, gas or other supporting environment suspected of containing one or more of the target materials. Specific binding interactions between the target materials and a particular affinity domain occurs and is detected by various methods.

公开(公告)号：EP1330536A1

公开(公告)日：2003-07-30

申请号：EP01979651.5

申请日：2001-10-10

申请人： Bioforce Nanosciences, Inc.

发明人： HENDERSON, Eric ,  MOSHER, Curtis

IPC分类号： C12Q1/00 ,  C12M1/34 ,  G01N27/26

CPC分类号： B82Y15/00 ,  C12Q1/001 ,  C12Q1/48 ,  G01N27/041 ,  G01N33/54373 ,  G01N2333/91245

摘要： In the present invention, organic, inorganic, or other molecules or objects that may participate in an interaction event, are physically linked to nanoscale objects, typified, but not limited to, carbon nanotubes, silicon nanotubes, nanobars, and biological structural elements, such as microtubules and actin filaments, to create a signal transduction system that reports events on the micron scale or smaller. A molecular interaction even is monitored utilizing an amp meter or utilizing a scanning tunneling microscope so that when the molecules or objects participate in a molecule interaction event, or some other interaction event, the movement or change in the physical properties of the nanotube is monitored to report the occurrence of the interaction event.

公开(公告)号：EP1622500A4

公开(公告)日：2007-01-24

申请号：EP04750985

申请日：2004-04-30

申请人： BIOFORCE NANOSCIENCES INC

发明人： HENDERSON ERIC R ,  JOHNSON JAMES ,  NETTIKADAN SAJU

IPC分类号： C12Q1/68 ,  G01Q80/00 ,  A61B20060101 ,  G01N1/31 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01Q10/00 ,  G01Q60/00 ,  G01Q60/18 ,  G01Q60/20 ,  G01Q70/18

CPC分类号： C12Q1/6816 ,  G01N33/54366 ,  G01N33/5438 ,  G01N33/6854 ,  G01Q60/20 ,  C12Q2565/501 ,  C12Q2565/601

摘要： Provided are methods of detecting molecular interactions using arrays and near field scanning probe techniques. Also provided are methods of characterizing binding interactions under defined reaction parameters, methods of determining antibody binding specificity, methods of selecting a substrate for an array of immobilized molecules and methods of determining molecular occupancy time with respect to binding interactions.

公开(公告)号：EP1583845A4

公开(公告)日：2006-06-28

申请号：EP03800411

申请日：2003-12-30

申请人： BIOFORCE NANOSCIENCES INC

发明人： HENDERSON ERIC ,  MOSHER CURTIS ,  HUFF JANICE

IPC分类号： C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N35/00 ,  G01Q10/00 ,  G01Q60/24 ,  G01Q60/42 ,  B01J19/00 ,  C12M1/26 ,  C12M3/00 ,  G01B7/34 ,  G01N13/16 ,  G01N33/53

CPC分类号： G01N33/54373 ,  B01J2219/00387 ,  B01J2219/00605 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N2035/00158 ,  G01Q60/42

摘要： The interrogation of extremely small sample volumes can be accomplished with the present invention. Provided are probes having disposed thereon a plurality of domains forming an array, which is suitably a nanoarray. Also provided are methods of detecting molecules and molecular interaction events, retrieving and analyzing analytes, and delivering substances to cells or tissues using probes of the invention.

公开(公告)号：EP1348113A4

公开(公告)日：2006-03-01

申请号：EP01993149

申请日：2001-08-14

申请人： BIOFORCE NANOSCIENCES INC

发明人： HENDERSON ERIC ,  MOSHER CURTIS

IPC分类号： B01J19/00 ,  G01N13/10 ,  B01L3/00 ,  B01L3/02 ,  B82B3/00 ,  C12M1/36 ,  C12N11/16 ,  C40B40/06 ,  C40B50/14 ,  G01N1/14 ,  G01N13/16 ,  G01N15/06 ,  G01N33/543

CPC分类号： B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00698 ,  B01J2219/00704 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01L3/0244 ,  B82B3/00 ,  C40B40/06 ,  C40B50/14 ,  Y10S977/924

摘要： The present invention is a dedicated apparatus for the formation of array that includes one or more deposition domains comprised of one or more deposition materials. The present invention may include an X, Y controller, an X, Y translation stage, a loading substrate, a deposition substrate, a Z controller, and a deposition probe. A computer controls all of the relative positions of each of the components. Furthermore, the present invention utilizes a humidity control system to create a capillary bridge between the probe and the substrate for transferring the deposition material between the loading substrate, the deposition probe, and the deposition substrate.