公开(公告)号：EP2131878A4

公开(公告)日：2012-12-26

申请号：EP08712858

申请日：2008-02-29

申请人： DOXA AB

发明人： HERMANSSON LEIF ,  ENGQVIST HAAKAN

IPC分类号： A61L24/02 ,  A61K6/06 ,  A61L24/00 ,  A61L27/10 ,  A61L27/42 ,  A61L27/44

CPC分类号： A61L24/02 ,  A61K6/0008 ,  A61K6/0088 ,  A61K6/024 ,  A61K6/0612 ,  A61K6/0631 ,  A61L24/0068 ,  A61L24/0089 ,  A61L27/10 ,  A61L27/105 ,  A61L27/427 ,  A61L27/446 ,  A61L2400/06 ,  A61K6/087 ,  C08L69/00 ,  A61K6/097 ,  C08L1/28

公开(公告)号：EP2182912A1

公开(公告)日：2010-05-12

申请号：EP07794184.7

申请日：2007-08-23

申请人： Doxa AB

发明人： HERMANSSON, Leif ,  LÖÖF, Jesper ,  ENGQVIST, Håkan

IPC分类号： A61K6/06

CPC分类号： A61K6/0008 ,  A61K6/0023 ,  A61K6/0631 ,  A61K6/0675 ,  C08L33/08 ,  A61K6/0835

摘要： A dental cement system, comprising an aqueous hydration liquid and a powdered material that essentially consists of an inorganic cement system, which powdered material has the capacity to form a complex, chemically bonded material with inorganic as well as organic phases with properties suitable for cementation of implant to another implant and/or to tooth or bone tissue. The invention relates to the powdered material and the hydration liquid, respectively, as well as the formed ceramic material and a kit comprising the system.

公开(公告)号：EP1795171B1

公开(公告)日：2014-11-19

申请号：EP05111859.4

申请日：2005-12-08

申请人： Doxa AB

发明人： Hermansson, Leif ,  Engqvist, Håkan

IPC分类号： A61K6/06 ,  A61K6/083 ,  A61L24/00 ,  A61L27/42 ,  C04B22/10 ,  C04B22/08 ,  C04B22/14 ,  C04B22/12 ,  C04B22/16 ,  C04B12/04 ,  C04B28/18

CPC分类号： C04B28/06 ,  A61K6/0008 ,  A61K6/0067 ,  A61K6/0215 ,  A61K6/0612 ,  A61K6/0631 ,  A61K6/0675 ,  A61L24/0068 ,  A61L27/427 ,  C04B20/107 ,  C04B2111/00836 ,  C04B7/00 ,  C04B22/16 ,  C04B20/002 ,  C04B22/14 ,  C04B22/126 ,  C04B22/10

公开(公告)号：EP2059270B1

公开(公告)日：2013-06-12

申请号：EP07794211.8

申请日：2007-08-31

申请人： Doxa AB

发明人： HERMANSSON, Leif ,  PERSSON, Tobias ,  ENGQVIST, Håkan

IPC分类号： A61L27/30 ,  A61L31/08 ,  A61L33/02

CPC分类号： A61L31/088 ,  A61L27/306 ,  A61L33/027

公开(公告)号：EP2139531A4

公开(公告)日：2013-01-09

申请号：EP08724310

申请日：2008-03-28

申请人： DOXA AB

发明人： HERMANSSON LEIF ,  ENGQVIST HAAKAN

IPC分类号： A61L27/10 ,  A61K6/06 ,  A61K9/22 ,  A61K47/02 ,  C04B7/32

CPC分类号： A61K9/1611 ,  A61K9/0024 ,  A61L27/10 ,  A61L27/105 ,  A61L27/12 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/602 ,  C04B18/021 ,  C04B28/06 ,  C04B28/18 ,  C04B2111/00215 ,  C04B2111/00836 ,  C04B2111/23 ,  C04B2111/27 ,  C04B14/303 ,  C04B14/322 ,  C04B14/325 ,  C04B18/027 ,  C04B20/10 ,  C04B14/324 ,  C04B14/366 ,  C04B16/08 ,  C04B38/0074 ,  C04B14/22 ,  C04B14/328 ,  C04B14/365

摘要： The present invention relates to chemically bonded ceramic precursor material of aluminates and silicates exhibiting a controlled release rate and properties that make the material suitable as a carrier material used in drug delivery. According to the invention, this is accomplished by selecting a microstructure based on pre-reacted phases and/or reacting phases, which contains the drugs. The present invention also relates to a cured ceramic material and a method of manufacturing said cured material. The precursor and the cured ceramic material according to the present invention can suitably be used for different types of drug intake and delivery.

摘要翻译： 本发明涉及化学键合的铝酸盐和硅酸盐的陶瓷前体材料，其表现出控制释放速率和性质，使材料适合作为药物递送中使用的载体材料。 根据本发明，这是通过选择基于预反应相的微观结构和/或反应含有药物的相来完成的。 本发明还涉及固化的陶瓷材料和制造所述固化材料的方法。 根据本发明的前体和固化陶瓷材料可适用于不同类型的药物摄取和输送。

公开(公告)号：EP2485776A1

公开(公告)日：2012-08-15

申请号：EP09740546.8

申请日：2009-10-09

申请人： Doxa AB

发明人： HERMANSSON, Leif ,  LÖÖF, Jesper ,  FARIS, Adam

IPC分类号： A61L24/00 ,  A61L27/10 ,  A61L27/44 ,  A61K6/06 ,  C04B24/04 ,  C04B28/00

CPC分类号： A61L27/446 ,  A61K6/0205 ,  A61K6/0835 ,  A61L24/0089 ,  A61L27/10 ,  C04B28/06 ,  C04B2111/00836 ,  C04B7/02 ,  C04B14/22 ,  C04B20/008 ,  C04B22/124 ,  C04B24/04 ,  C04B24/2641

摘要： The present invention generally relates to chemically bonded ceramic biomaterials, preferably a dental material or an implant material, comprising two binder systems. The main binder system forms a chemically bonded ceramic upon hydration thereof, and comprises powdered calcium aluminate and, optionally, minor amounts of calcium silicate. The second binder system is a cross-linking organic binder system which provides for initial crosslinking of the freshly mixed paste forming the biomaterial. The biomaterial also comprises inert filler particles. The inventive biomaterial is free from reactive glass and thus provides for a simplified two binder systems biomaterial with a reduced number of required reactive components The invention relates to a powdered composition for preparing the inventive chemically bonded ceramic biomaterial, and a paste from which the biomaterial is formed, as well as a kit comprising the powdered composition and hydration liquid, as well as methods and use of the biomaterial in dental and implant applications.

公开(公告)号：EP1465580B1

公开(公告)日：2011-11-16

申请号：EP02793697.0

申请日：2002-12-19

申请人： Doxa AB

发明人： AXEN, Niklas ,  HERMANSSON, Leif ,  JOHANSSON, Erik ,  PERSSON, Tobias

IPC分类号： A61K6/06 ,  A61L27/30 ,  C23C24/00

CPC分类号： A61L27/30 ,  A61L31/082 ,  C23C10/18 ,  C23C24/08

摘要： Surface coating method for deposition of a chemically bonded ceramic coating on a substrate, comprising the steps of preparing a curable coating slurry, depositing a coating of the slurry on at least a section of the substrate surface, and hardening the slurry. According to the invention the step of preparing a curable coating slurry comprises mixing calcium aluminate powder with water and at least one water-reducing-agent, such that a water-to-cement ratio in the range of 0.1 to 0.9 is achieved. The invention further relates to a biocompatible surface coating with a binder phase of calcium aluminate hydrate and a device coated with such a biocompatible surface coating.

公开(公告)号：EP1778163A4

公开(公告)日：2010-02-24

申请号：EP05774832

申请日：2005-08-17

申请人： DOXA AB

发明人： ENGQVIST HAAKAN ,  HERMANSSON LEIF ,  LOEOEF JESPER ,  SPENGLER HAAKAN

IPC分类号： A61K6/06 ,  A61L20060101 ,  A61L27/10 ,  A61L27/42 ,  C04B28/02 ,  C04B28/06 ,  C04B28/34 ,  C04B35/80 ,  C04B35/82

CPC分类号： A61L27/42 ,  A61K6/0008 ,  A61K6/0085 ,  A61K6/0091 ,  A61K6/0612 ,  A61K6/0643 ,  A61K6/0668 ,  A61K6/0675 ,  A61L27/105 ,  C04B28/02 ,  C04B28/06 ,  C04B28/34 ,  C04B2111/00836 ,  C04B20/0048 ,  C04B24/2641 ,  C04B14/42 ,  A61K6/083 ,  C08L33/08

公开(公告)号：EP2073855A4

公开(公告)日：2012-11-21

申请号：EP07835330

申请日：2007-10-16

申请人： DOXA AB

发明人： HERMANSSON LEIF ,  ENGQVIST HAAKAN

IPC分类号： A61L24/02 ,  A61K6/06 ,  A61L27/10

CPC分类号： A61L24/0042 ,  A61L24/02 ,  A61L27/306 ,  A61L27/58 ,  A61L2400/06 ,  C04B28/344 ,  C04B2111/00836 ,  C04B11/28 ,  C04B14/043 ,  C04B14/366 ,  C04B22/143

公开(公告)号：EP1796749A4

公开(公告)日：2011-08-17

申请号：EP05779214

申请日：2005-09-09

申请人： DOXA AB

发明人： HERMANSSON LEIF ,  ENGQVIST HAAKAN

IPC分类号： A61L27/10 ,  A61K47/02 ,  A61L20060101 ,  A61L27/12 ,  A61L27/42 ,  A61L27/58

CPC分类号： C04B28/06 ,  A61K6/0085 ,  A61K6/0091 ,  A61K6/024 ,  A61K6/0612 ,  A61K6/0675 ,  A61K6/0681 ,  A61L27/12 ,  A61L27/425 ,  A61L27/58 ,  C04B28/02 ,  C04B28/025 ,  C04B28/145 ,  C04B28/344 ,  C04B2111/00836 ,  Y02P40/148 ,  C04B22/143 ,  C04B7/02 ,  C04B7/32 ,  A61K6/083 ,  C08L33/08

摘要： Ceramic precursor compositions and chemically bonded ceramic (CBC) materials, especially Ca-based, and a composite biomaterial suitable for orthopaedic applications. The CBC-system includes a binding phase (chemical cement) and additional phases with specified chemistry imparting to the biomaterial the ability of initial strength followed by interaction with the body tissue including body liquid, to form a resorbable or partly resorbable biomaterial. The ceramic precursor composition includes at least one silicate with Ca as the main cation with a resorption rate less or equal to that of the bone in-growth rate. The silicate will form the binding phase of the cured material. Implants and surface coated devices are also disclosed. The cured material exhibits a compressive strength exceeding 100 MPa.