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公开(公告)号：EP3579864B1
公开(公告)日：2023-04-12
申请号：EP18708005.6
申请日：2018-02-09
IPC分类号： A61K38/16 , C07K14/285 , A61P31/04 , G01N33/68 , G01N33/569 , A61K39/40 , A61K39/102 , A61K39/00
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公开(公告)号：EP0749321B1
公开(公告)日：2007-01-24
申请号：EP95911683.1
申请日：1995-02-09
申请人： Epitopix LLC
IPC分类号： A61K39/00 , A61K39/38 , A61K39/40 , A61K39/102 , A61K39/108 , A61K39/395 , A61K39/112 , A61K39/104 , C07K16/12
CPC分类号： C07K14/245 , A61K39/0258 , A61K39/0275 , A61K39/102 , G01N33/56911 , G01N33/56916 , Y02A50/474 , Y02A50/482 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S530/825
摘要： The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.
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3.发明授权IMMUNIZING COMPOSITIONS AND METHODS OF USE 有权ZUSAMMENSETZUNGEN ZUR IMMUNISIERUNG SOWIE DEREN VERWENDUNG
公开(公告)号：EP1353689B9
公开(公告)日：2006-06-28
申请号：EP02705685.2
申请日：2002-01-03
申请人： Epitopix LLC
IPC分类号： A61K39/108 , A61K39/112 , A61P37/04
CPC分类号： A61K39/0275 , A61K31/739 , A61K39/085 , A61K39/39 , A61K2039/552 , A61K2039/55572 , C07K14/24 , G01N33/53 , Y02A50/482 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/827 , Y10S424/828 , Y10S424/829
摘要： The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
摘要翻译： 本发明提供了包含来自革兰氏阴性微生物的铁载体受体多肽和孔蛋白的组合物，优选浓度不超过约10.0内毒素单位/毫升的脂多糖。 本发明还提供了制备方法和使用这些组合物的方法。
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4.发明授权POLYPEPTIDES AND IMMUNIZING COMPOSITIONS CONTAINING GRAM POSITIVE POLYPEPTIDES AND METHODS OF USE 有权含有GRP阳性多肽的多肽和免疫组合物及使用方法
公开(公告)号：EP2411046B1
公开(公告)日：2017-12-06
申请号：EP10756718.2
申请日：2010-03-23
申请人： Epitopix, LLC
IPC分类号： A61K39/085 , A61K39/38 , C07K14/31
CPC分类号： C07K14/31 , A61K38/00 , A61K39/085
摘要： The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
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公开(公告)号：EP1853306B1
公开(公告)日：2016-06-15
申请号：EP06734951.4
申请日：2006-02-14
申请人： Epitopix, LLC
IPC分类号： A61K39/085 , A61K39/40 , C07K14/31 , G01N33/569
CPC分类号： A61K39/085 , A61K38/00 , A61K38/164 , A61K39/00 , A61K2039/505 , A61K2039/575 , C07K7/06 , C07K7/08 , C07K14/31 , C07K16/1271 , C07K16/1275 , C07K16/1285 , C07K16/1289 , C07K2317/14 , C07K2317/34 , C07K2317/76 , G01N33/56938 , Y10S530/825
摘要： The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compostions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
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公开(公告)号：EP1784417B1
公开(公告)日：2016-05-18
申请号：EP05792876.4
申请日：2005-08-25
申请人： Epitopix, LLC
IPC分类号： C07K14/195
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , A61K39/39 , A61K2039/505 , C12N1/20 , C12P21/00 , C12R1/01
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公开(公告)号：EP2361926A2
公开(公告)日：2011-08-31
申请号：EP11075020.5
申请日：2006-01-20
申请人： Epitopix, LLC
CPC分类号： A61K39/0291 , A61K39/00 , A61K39/025 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/575 , C07K14/24 , C07K16/1228 , A61K2300/00
摘要： The present invention provides isolated Polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the Polypeptides, and methods for making and methods for using the Polypeptides.
摘要翻译： 本发明提供了从耶尔森氏菌属物种分离的分离的多肽。 本发明还提供了包含一种或多种多肽的组合物，以及制备方法和使用该多肽的方法。
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8.发明公开
公开(公告)号：EP3579864A1
公开(公告)日：2019-12-18
申请号：EP18708005.6
申请日：2018-02-09
申请人： Epitopix, LLC
IPC分类号： A61K38/16 , A61K39/102 , A61K39/40 , G01N33/569 , G01N33/68 , A61P31/04 , C07K14/285
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公开(公告)号：EP3319628A2
公开(公告)日：2018-05-16
申请号：EP16745287.9
申请日：2016-07-08
申请人： Epitopix, LLC
IPC分类号： A61K39/02 , A61K39/108
CPC分类号： A61K39/0266 , A61K2039/552 , A61K2039/55566 , C07K14/26
摘要： Provided herein are isolated proteins isolatable from a Klebsiella spp. Also provided are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.
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10.发明公开
公开(公告)号：EP1678316A2
公开(公告)日：2006-07-12
申请号：EP04784662.1
申请日：2004-09-20
申请人： Epitopix LLC
IPC分类号： C12Q1/00
CPC分类号： A61K39/0258 , A61K39/0275 , A61K39/105 , A61K2039/54 , A61K2039/542 , A61K2039/545 , A61K2039/55 , A61K2039/552 , C07K14/205 , C07K14/245 , C07K14/255 , Y10S530/825
摘要： The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.
摘要翻译： 本发明提供了包含具有由参考微生物如大肠杆菌或沙门氏菌表达的多肽特征的多肽的组合物。 可以使用的沙门氏菌属菌株的实例包括例如肠杆菌血清型Newport，肠杆菌肠炎沙门氏菌，肠炎沙门氏菌血清型鼠伤寒沙门氏菌和肠氏乳杆菌血清型都柏林。 还提供了包括具有特定分子量的多肽和包括具有特定质量组的多肽片段的质量指纹的组合物，或具有与氨基酸序列具有至少约95％同一性的氨基酸序列的多肽，其中多肽具有 血清活性。 本发明还提供了制备方法和使用这些组合物的方法。
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