公开(公告)号：EP4419657A1

公开(公告)日：2024-08-28

申请号：EP22884651.5

申请日：2022-10-18

申请人： Genomatica, Inc.

发明人： SHAH, Amit Mahendra ,  COLQUITT, Justin Robert ,  WARNER, Joseph Roy ,  SCHMIDT, Nathan ,  PRAVESCHOTINUNT, Pichet

IPC分类号： C12N9/04 ,  C12N15/52

CPC分类号： C12N15/52 ,  C12N9/0008 ,  C12R2001/14520210501 ,  C12P7/24 ,  C12P7/18 ,  C12R2001/1920210501 ,  C12Y102/01003

公开(公告)号：EP4405326A1

公开(公告)日：2024-07-31

申请号：EP22793384.3

申请日：2022-09-19

申请人： Covestro Deutschland AG ,  Genomatica, Inc.

发明人： MERKEL, Michael

IPC分类号： C07C209/84 ,  C07C211/12 ,  C07C211/09 ,  C07C263/10 ,  C07C265/14 ,  C12P13/00 ,  C08G18/00

CPC分类号： C07C209/84 ,  C07C263/10 ,  C07C209/00 ,  C07C211/09 ,  C07C211/12 ,  C07C265/14 ,  C12P13/001

公开(公告)号：EP3611254B1

公开(公告)日：2023-07-05

申请号：EP19186319.0

申请日：2010-05-07

发明人： BURK, Mark J. ,  BURGARD, Anthony P. ,  OSTERHOUT, Robin E. ,  PHARKYA, Priti

IPC分类号： C12N1/38 ,  C12N15/52 ,  C12P7/40 ,  C12P7/44 ,  C12P13/02 ,  C12P17/10 ,  C12P13/00

公开(公告)号：EP2129785B2

公开(公告)日：2021-11-17

申请号：EP08744695.1

申请日：2008-03-28

发明人： HU, Zhihao ,  VALLE, Fernando

IPC分类号： C12P7/64 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/16 ,  C10L1/02 ,  C12N1/19 ,  C12N1/21

公开(公告)号：EP3739057A1

公开(公告)日：2020-11-18

申请号：EP20171012.6

申请日：2015-04-10

申请人： Genomatica, Inc.

发明人： DEL CARDAYRE, Stephen, B. ,  SCHIRMER, Andreas, W. ,  KO, Myong ,  WANG, Haibo

IPC分类号： C12P7/42 ,  C12P7/44 ,  C07C45/45 ,  C07C45/62 ,  C07C45/65 ,  C12P17/04

摘要： The present disclosure relates to processes that combine microbial production of organic intermediates and subsequent synthetic transformation to provide compounds of industrial value, including compounds used in fragrances.

公开(公告)号：EP3739042A1

公开(公告)日：2020-11-18

申请号：EP20179698.4

申请日：2014-09-12

申请人： Genomatica, Inc.

发明人： GREENFIELD, Derek L. ,  TRIMBUR, Donald E. ,  SCHIRMER, Andreas ,  CHANG, Cindy ,  BEHROUZIAN, Behnaz ,  WINGER, Jessica

IPC分类号： C12N9/00 ,  C12P7/64

摘要： The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

公开(公告)号：EP3690035A3

公开(公告)日：2020-10-21

申请号：EP20160184.6

申请日：2015-06-16

申请人： Genomatica, Inc.

发明人： ZHU, Baolong ,  SCHIRMER, Andreas W ,  CHANG, Cindy

IPC分类号： C12N9/02 ,  C07K19/00 ,  C12P7/42 ,  C12P7/64

摘要： The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：EP2888369B1

公开(公告)日：2020-07-15

申请号：EP13832246.6

申请日：2013-08-27

申请人： Genomatica, Inc.

发明人： BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  VAN DIEN, Stephen, J. ,  TRACEWELL, Cara, Ann ,  PHARKYA, Priti ,  ANDRAE, Stefan

IPC分类号： C12P7/18 ,  C12N1/21 ,  C12N9/04 ,  C12N9/06 ,  C12N9/10 ,  C12N9/88

公开(公告)号：EP3647430A1

公开(公告)日：2020-05-06

申请号：EP19198410.3

申请日：2014-12-05

申请人： Genomatica, Inc.

发明人： DEL CARDAYRE, Stephen B. ,  HOM, Louis G.

IPC分类号： C12P13/00 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N9/02 ,  C12N9/06 ,  C12N9/16 ,  C12N1/21

摘要： The disclosure relates to recombinant microorganisms for the production of fatty amines and derivatives thereof. Further contemplated are cultured recombinant host cells as well as methods of producing fatty amines by employing these host cells.

公开(公告)号：EP3368548A1

公开(公告)日：2018-09-05

申请号：EP16791508.1

申请日：2016-10-27

申请人： Genomatica, Inc.

发明人： BARTON, Nelson R. ,  LI, Jingyi ,  WARNER, Joseph R. ,  PHARKYA, Priti

IPC分类号： C07K14/195 ,  C12N15/62 ,  C12N5/00

CPC分类号： C12Y503/01027 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y401/02043

摘要： Described herein are fusion proteins including methanol dehydrogenase (MeDH) and at least one other polypeptide such as 3-hexulose-6-phosphate dehydrogenase (HPS) or 6-phospho-3-hexuloisomerase (PHI), such as DHAS synthase or fructose-6-Phosphate aldolase or such as DHA synthase or DHA kinase. In a localized manner, the fusion protein can promote the conversion of methanol to formaldehyde and then to a ketose phosphate such as hexulose 6-phosphate or then to DHA and G3P. When expressed in cells, the fusion proteins can promote methanol uptake and rapid conversion to the ketose phosphate or to the DHA and D3P, which in turn can be used in a pathway for the production of a desired bioproduct. Beneficially, the rapid conversion to the ketose phosphate or to the DHA and G3P can avoid the undesirable accumulation of formaldehyde in the cell. Also described are engineered cells expressing the fusion protein, optionally include one or more additional metabolic pathway transgene(s), methanol metabolic pathway genes, target product pathway genes, cell culture compositions including the cells, methods for promoting production of the target product or intermediate thereof from the cells, compositions including the target product or intermediate, and products made from the target product or intermediate.