公开(公告)号：EP2855687B1

公开(公告)日：2020-04-22

申请号：EP13800646.5

申请日：2013-06-03

申请人： Genomatica, Inc.

发明人： BURK, Mark, J. ,  PHARKYA, Priti ,  BURGARD, Anthony, P. ,  VAN DIEN, Stephen, J. ,  OSTERHOUT, Robin, E. ,  TRAWICK, John, D. ,  KUCHINSKAS, Michael, P. ,  STEER, Brian

IPC分类号： C12P7/52 ,  C12N1/20 ,  C12N1/21

公开(公告)号：EP2906705A1

公开(公告)日：2015-08-19

申请号：EP13846388.0

申请日：2013-10-14

申请人： Genomatica, Inc.

发明人： OSTERHOUT, Robin, E. ,  BURGARD, Anthony, P.

IPC分类号： C12P7/04 ,  C12P7/40 ,  C12P7/64 ,  C07C53/00 ,  C07C57/00 ,  C07C29/00 ,  C07C31/02 ,  C07C33/00 ,  C07C47/263 ,  C12N1/00

CPC分类号： C12P7/64 ,  C07C31/207 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1217 ,  C12N9/1294 ,  C12N9/13 ,  C12N9/16 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P7/04 ,  C12P7/24 ,  C12P7/6409 ,  C12Y101/01035 ,  C12Y101/01037 ,  C12Y101/05004 ,  C12Y101/05006 ,  C12Y101/99033 ,  C12Y102/01 ,  C12Y102/01002 ,  C12Y102/01003 ,  C12Y102/0101 ,  C12Y102/01015 ,  C12Y102/01018 ,  C12Y102/01027 ,  C12Y102/01042 ,  C12Y102/0105 ,  C12Y102/01076 ,  C12Y102/05001 ,  C12Y103/01044 ,  C12Y103/99012 ,  C12Y203/01008 ,  C12Y203/01016 ,  C12Y203/01054 ,  C12Y203/01174 ,  C12Y203/03008 ,  C12Y207/02001 ,  C12Y207/02007 ,  C12Y207/09002 ,  C12Y208/03003 ,  C12Y301/03001 ,  C12Y301/03002 ,  C12Y301/0302 ,  C12Y301/0306 ,  C12Y401/01 ,  C12Y401/01001 ,  C12Y401/01003 ,  C12Y401/01007 ,  C12Y401/01009 ,  C12Y401/01031 ,  C12Y401/01032 ,  C12Y401/01049 ,  C12Y401/01074 ,  C12Y401/01082 ,  C12Y401/02005 ,  C12Y401/03006 ,  C12Y401/03034 ,  C12Y402/01017 ,  C12Y602/01001 ,  C12Y602/01013 ,  C12Y602/01018 ,  C12Y604/01001

摘要： The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid.

公开(公告)号：EP2558582A1

公开(公告)日：2013-02-20

申请号：EP11769508.0

申请日：2011-04-13

申请人： Genomatica, Inc.

发明人： OSTERHOUT, Robin, E. ,  PHARKYA, Prit ,  BURGARD, Anthony, P.

IPC分类号： C12P7/04 ,  C12N1/21

CPC分类号： C12P7/18 ,  C12N15/52 ,  C12Y101/01029 ,  C12Y101/01077 ,  C12Y101/01081 ,  C12Y104/01 ,  C12Y104/01018 ,  C12Y104/03008 ,  C12Y206/01 ,  C12Y401/01 ,  C12Y401/0104 ,  C12Y401/01073

摘要： The invention provides non-naturally occurring microbial organisms having an ethylene glycol pathway. The invention additionally provides methods of using such organisms to produce ethylene glycol.

摘要翻译： 本发明提供了具有乙二醇途径的非天然存在的微生物。 本发明另外提供了使用这些生物体生产乙二醇的方法。

公开(公告)号：EP2334800A2

公开(公告)日：2011-06-22

申请号：EP09813563.5

申请日：2009-09-09

申请人： Genomatica, Inc.

发明人： BURK, Mark, J. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun

IPC分类号： C12P7/16 ,  C12P1/04

CPC分类号： C12P7/18 ,  B01D3/002 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/12 ,  C12N9/13 ,  C12N9/16 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12N15/52 ,  C12N15/70 ,  C12N15/81 ,  C12Y101/01157 ,  C12Y402/01055

摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.

公开(公告)号：EP2265709A2

公开(公告)日：2010-12-29

申请号：EP09763021.4

申请日：2009-03-27

申请人： Genomatica, Inc.

发明人： BURGARD, Anthony, P. ,  PHARKYA, Priti ,  OSTERHOUT, Robin, E.

IPC分类号： C12N1/21 ,  C12P13/04 ,  C12P7/44

CPC分类号： C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/80 ,  C12N9/88 ,  C12P7/44 ,  C12P7/46 ,  C12P7/62 ,  C12P13/001 ,  C12P13/005 ,  C12P13/02 ,  C12P17/10 ,  C12Y101/01035 ,  C12Y102/0101 ,  C12Y103/01031 ,  C12Y206/01 ,  C12Y402/01

摘要： The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6- aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.

公开(公告)号：EP2427544B1

公开(公告)日：2019-07-17

申请号：EP10772921.2

申请日：2010-05-07

申请人： Genomatica, Inc.

发明人： BURK, Mark, J. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  PHARKYA, Priti

IPC分类号： C12N1/38 ,  C12N15/52 ,  C12P7/40 ,  C12P7/44 ,  C12P13/02 ,  C12P17/10 ,  C12P13/00

公开(公告)号：EP2265709B1

公开(公告)日：2017-11-08

申请号：EP09763021.4

申请日：2009-03-27

申请人： Genomatica, Inc.

发明人： BURGARD, Anthony, P. ,  PHARKYA, Priti ,  OSTERHOUT, Robin, E.

IPC分类号： C12N1/21 ,  C12P13/04 ,  C12P7/44

CPC分类号： C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/80 ,  C12N9/88 ,  C12P7/44 ,  C12P7/46 ,  C12P7/62 ,  C12P13/001 ,  C12P13/005 ,  C12P13/02 ,  C12P17/10 ,  C12Y101/01035 ,  C12Y102/0101 ,  C12Y103/01031 ,  C12Y206/01 ,  C12Y402/01

公开(公告)号：EP2773767A1

公开(公告)日：2014-09-10

申请号：EP12845401.4

申请日：2012-11-02

申请人： Genomatica, Inc.

发明人： BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  PHARKYA, Priti ,  BURK, Mark, J.

IPC分类号： C12P17/02

CPC分类号： C12P17/08 ,  C07D313/04 ,  C08G18/4277 ,  C08G63/08 ,  C12N5/0018 ,  C12N15/52 ,  C12N15/63 ,  C12N15/70 ,  C12P17/02

摘要： The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.

公开(公告)号：EP2475775A1

公开(公告)日：2012-07-18

申请号：EP10816105.0

申请日：2010-09-09

申请人： Genomatica, Inc.

发明人： PHARKYA, Priti ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  BURK, Mark, J. ,  SUN, Jun

IPC分类号： C12P7/04 ,  C12N15/74

CPC分类号： C12P7/40 ,  C12N15/52 ,  C12P7/04 ,  C12P7/18

摘要： The invention provides a non-naturally occurring microbial organism having n-propanol and isopropanol pathways, 1,4-butanediol (14-BDO) and isopropanol pathways, 1,3-butanediol (13- BDO) and isopropanol pathways or methylacrylic acid (MAA) and isopropanolpathways. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in each of the respective n-propanol, 14-BDO, 13-BDO or MAA and isopropanol pathways. The invention additionally provides a method for co-producing n-propanol and isopropanol, 14-BDO and isopropanol, 13-BDO and isopropanol or MAA and isopropanol. The method can include culturing an n-propanol and an isopropanol co-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an n-propanol, an isopropanol, a 14-BDO, a 13-BDO and/or a MAA pathway enzyme in a sufficient amount to produce each of the respective products, under conditions and for a sufficient period of time to produce each of the respective products.

公开(公告)号：EP2427544A1

公开(公告)日：2012-03-14

申请号：EP10772921.2

申请日：2010-05-07

申请人： Genomatica, Inc.

发明人： BURK, Mark, J. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  PHARKYA, Priti

IPC分类号： C12N1/21 ,  C12P13/04 ,  C12P7/44

CPC分类号： C12P17/10 ,  C12N1/38 ,  C12N15/52 ,  C12P7/40 ,  C12P7/44 ,  C12P13/001 ,  C12P13/005 ,  C12P13/02 ,  C12P17/12

摘要： The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.