-
公开(公告)号：EP2780026A2
公开(公告)日：2014-09-24
申请号：EP12850713.4
申请日：2012-11-09
申请人： Merck Sharp & Dohme Corp. , Merck Canada Inc. , Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L.
发明人： RUDD, Michael, T. , MCCAULEY, John , LIVERTON, Nigel , GRISE-BARD, Christiane , BROUCHU, Marie-Christine , CHARRON, Sylvie , AULAKH, Virender , BACHAND, Benoit , BEAULIEU, Patrick , ZAGHDANE, Helmi , HAN, Yongxin , FERRARA, Marco , HARPER, Steven , SUMMA, Vincenzo , CHACKALAMANNIL, Samuel , VENKATRAMAN, Srikanth , SHAH, Unmesh , VELAZQUEZ, Francisco
IPC分类号： A61K38/12
CPC分类号： C07K5/08 , A61K31/4745 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/005 , A61K38/06 , A61K38/12 , A61K38/21 , C07K5/0804 , C07K5/0808 , C07K5/0812 , C07K5/0821 , A61K2300/00
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
-
公开(公告)号：EP2550011A1
公开(公告)日：2013-01-30
申请号：EP11709969.7
申请日：2011-03-25
发明人： MONACI, Paolo , CARFI, Andrea
CPC分类号： A61K38/482 , A61K39/0005 , A61K2039/53 , C12N9/6408
摘要： The present invention relates to pharmaceutical compositions comprising PCSK9 DNA or PCSK9 proteins or PCSK9 peptides and CpG adjuvant; this composition is used to lower cholesterol levels specifically LDL cholesterol levels.
-
3.发明授权NUCLEOSIDE CYCLIC PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 有权循环核苷氨基磷酸酯FOR RNA-依赖性RNA病毒感染的治疗
-
4.发明公开Combinations containing amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors 有权聚合酶（ADP-核糖） - 聚合酶（PARP） - 聚合酶
公开(公告)号：EP2336120A1
公开(公告)日：2011-06-22
申请号：EP11157369.7
申请日：2008-01-08
IPC分类号： C07D401/10 , A61K31/4439 , A61P35/00 , A61P29/00
CPC分类号： C07D401/10 , A61K31/4439
摘要： The present invention relates to combinations of compounds of formula I:
and other anti-cancer agents which are useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage and skin senescence and UV-induced skin damage.摘要翻译： 本发明涉及式I化合物与其它可用于治疗癌症，炎性疾病，再灌注损伤，缺血性疾病，中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病的抗癌剂的组合 ，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤和皮肤衰老以及紫外线诱发的皮肤损伤。
-
公开(公告)号：EP2398483B1
公开(公告)日：2014-09-24
申请号：EP09840594.7
申请日：2009-12-18
申请人： Merck Sharp & Dohme Corp. , Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. , Indiana University Research&Technology Corporation
发明人： CARRINGTON, Paul, E. , EIERMANN, George, J. , MARSH, Donald, J. , METZGER, Joseph. M. , POCAI, Alessandro , SINHA ROY, Ranabir , BIANCHI, Elisabetta , INGALLINELLA, Paolo , PESSI, Antonello , SANTOPRETE, Alessia , CAPITO, Elena , DIMARCHI, Richard , WARD, Brian
IPC分类号： A61K38/00 , C07K14/605 , C07K14/575
CPC分类号： C07K14/605 , A61K38/00 , C07K14/575
-
公开(公告)号：EP2676673A3
公开(公告)日：2014-03-19
申请号：EP13174153.0
申请日：2009-06-16
申请人： Indiana University Research and Technology Corporation , Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L.
发明人： Dimarchi, Richard D. , Smiley, David L. , Dimarchi, Maria , Chabenne, Joseph , Day, Jonathan , Patterson, James , Ward, Brian, C.
IPC分类号： A61K38/00 , C07K14/605
CPC分类号： C07K14/605
摘要： Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).
-
7.发明授权PHARMACEUTICAL COMPOSITIONS COMPRISING A MACROCYCLIC QUINOXALINE COMPOUND WHICH IS AN HCV NS3 PROTEASE INHIBITOR 有权药物组合物与大环喹喔啉具有HCV NS3蛋白酶抑制剂IS
-
公开(公告)号：EP1755667B1
公开(公告)日：2013-07-17
申请号：EP05804850.5
申请日：2005-05-27
IPC分类号： A61K39/12 , G01N33/68 , C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , G01N2333/16 , G01N2500/02
-
公开(公告)号：EP2121707B1
公开(公告)日：2012-12-05
申请号：EP07848727.9
申请日：2007-12-19
发明人： STANSFIELD, Ian , KOCH, Uwe , HABERMANN, Joerg , NARJES, Frank
IPC分类号： C07D513/04 , C07D513/18 , C07D515/18 , A61K31/407 , A61P31/14
CPC分类号： C07D515/18 , C07D513/04 , C07D513/18
-
公开(公告)号：EP1819700B1
公开(公告)日：2011-11-23
申请号：EP05852840.7
申请日：2005-12-02
IPC分类号： C07D413/12 , A61K31/513 , A61P31/18
CPC分类号： C07D239/557 , C07D313/12 , C07D413/12
摘要： Potassium salts of Compound A disclosed, wherein Compound A is of formula (I). Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.
-
-
-
-
-
-
-
-
-
搜索结果
25 条记录 (耗时 0.028 秒)
