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1622 条记录 (耗时 0.038 秒)

    Quinazoline derivatives as kinase inhibitors
    1.
    发明公开
    Quinazoline derivatives as kinase inhibitors 审中-公开
    Quinazolinderivate als Kinasehemmer

    公开(公告)号：EP2277877A1

    公开(公告)日：2011-01-26

    申请号：EP10182322.7

    申请日：2001-08-17

    申请人： MILLENNIUM PHARMACEUTICALS, INC. ,  Kyowa Hakko Kogyo Co., Ltd

    发明人： Pandey, Anjali ,  Scarborough, Carroll ,  Matsuno, Kenji ,  Ichimura, Michio ,  Nomoto, Yuji ,  Ide, Schinichi ,  Tsukuda, Eiji ,  Irie, Junko ,  Oda, Shoji

    IPC分类号： C07D403/12 ,  C07D239/94 ,  C07D401/12 ,  A61P35/00 ,  A61K31/517

    CPC分类号： C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D403/12

    摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinase and treating disese states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

    摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制激素和治疗哺乳动物中的二恶烷状态的方法。 在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化，血管 重建，癌症和肾小球硬化。

    PROCESS FOR PRODUCING GALACTOSE-CONTAINING COMPLEX SUGAR
    4.
    发明授权
    PROCESS FOR PRODUCING GALACTOSE-CONTAINING COMPLEX SUGAR 有权
    VERFAHREN ZUR HERSTELLUNG VON GALACTOSEHALTIGEM KOMPLEXEM ZUCKER

    公开(公告)号：EP1449924B1

    公开(公告)日：2008-12-24

    申请号：EP02800244.2

    申请日：2002-09-26

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： ENDO, Tetsuo ,  KOIZUMI, Satoshi, c/o Tokyo Research Laboratories

    IPC分类号： C12N15/54 ,  C12P21/02 ,  C12P19/18 ,  C12N9/10

    CPC分类号： C12P19/18 ,  C12N9/1051 ,  C12P19/26

    摘要： A process for producing a protein having an α1,4-galactosyltransferase activity with the use of a transformant containing a recombinant DNA having a DNA encoding a protein having an α1,4-galactosyltransferase activity originating in a microorganism belonging to the genus Pasteurella, and a galactose-containing complex sugar with the use of a transformant producing a protein having an α1,4-galactosyltransferase activity originating in a microorganism.

    摘要翻译： 本发明可以提供一种使用包含编码具有来源于巴斯德氏菌属的微生物的具有α1.4-半乳糖基转移酶活性的蛋白质的DNA的转化体的产生具有α1.4-半乳糖基转移酶活性的蛋白质的方法和含有半乳糖的 使用能够产生衍生自微生物的具有α-1.4-半乳糖基转移酶活性的蛋白质的转化体的复合碳水化合物。

    Process for producing dipeptides
    5.
    发明公开
    Process for producing dipeptides 审中-公开
    Reaktionsgemische zur Herstellung von Dipeptiden

    公开(公告)号：EP1983059A2

    公开(公告)日：2008-10-22

    申请号：EP08001323.8

    申请日：2003-12-29

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Hashimoto, Shin-ichi ,  Tabata, Kazuhiko ,  Hada, Aya ,  Ikeda, Hajime

    IPC分类号： C12P21/02 ,  C07K14/32 ,  C12N15/75

    CPC分类号： C12P21/02 ,  C12N9/00 ,  C12N9/54

    摘要： The present invention provides a protein having the activity to synthesize a dipeptide different from L-Ala-L-Ala and a protein for synthesis of the dipeptide, a process for producing the protein having the dipeptide-synthesizing activity, a process for producing the dipeptide using the protein having the dipeptide-synthesizing activity or the protein for the dipeptide synthesis, and a process for producing the dipeptide using a culture of a microorganism producing the protein having the dipeptide-synthesizing activity or the protein for the dipeptide synthesis or the like as an enzyme source.

    摘要翻译： 本发明提供了用于产生除了L-Ala-L-Ala之外的二肽的反应混合物，其包含a）蛋白质b）至少两种± - 氨基酸，和c）ATP。

    PROCESS FOR PRODUCING USEFUL SUBSTANCE
    7.
    发明公开
    PROCESS FOR PRODUCING USEFUL SUBSTANCE 审中-公开
    VERFAHREN ZUR HERSTELLUNG EINERNÜTZLICHENSUBSTANZ

    公开(公告)号：EP1939301A1

    公开(公告)日：2008-07-02

    申请号：EP06810702.8

    申请日：2006-09-28

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： HARA, Kiyotaka ,  KATO, Makiko ,  MORI, Hideo

    IPC分类号： C12P1/04 ,  C12N15/09

    CPC分类号： C12N1/00 ,  C12P7/00 ,  C12P13/04 ,  C12P19/34 ,  C12P21/00

    摘要： The present invention provides processes of producing useful substances, which include the steps of culturing in a medium microorganisms that lack from their chromosomal DNA all or part of a gene encoding a protein having the amino acid sequence shown in SEQ ID NO: 1 or a gene encoding a protein that is 80% or more homologous to the amino acid sequence shown in SEQ ID NO: 1 so as to produce and accumulate the useful substances in the culture, and recovering the useful substances from the culture.

    摘要翻译： 本发明提供生产有用物质的方法，其包括以下步骤：在培养基中缺乏染色体DNA的微生物全部或部分编码具有SEQ ID NO：1所示氨基酸序列的蛋白质的基因或基因 编码与SEQ ID NO：1所示的氨基酸序列同源的80％以上的蛋白质，以在培养物中产生和积累有用物质，并从培养物中回收有用物质。