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公开(公告)号：EP1543034A2
公开(公告)日：2005-06-22
申请号：EP03764649.4
申请日：2003-07-14
发明人： CHEN, Lieping , FU, Yang-Xin
CPC分类号： C07K16/2878 , A61K39/39541 , A61K2039/505 , C07K2317/73 , C07K2319/30 , A61K2300/00
摘要： Material and method for using 4-1BB agonizes to treat or prevent autoimmune disorders, lymphoproliferative diseases, and allergies are provided.
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公开(公告)号：EP1455669A2
公开(公告)日：2004-09-15
申请号：EP02789599.4
申请日：2002-11-13
发明人： FRIEDMAN, Paul, A.
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/00375 , A61B2090/3782
摘要： The invention provides for a tissue ablation device and methods of using such a tissue ablation device (1) for treating cardiac arrhythmias.
摘要翻译： 本发明提供了一种组织消融装置和使用这种组织消融装置（1）来治疗心脏心律不齐的方法。
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公开(公告)号：EP1385989A2
公开(公告)日：2004-02-04
申请号：EP02731168.7
申请日：2002-03-27
IPC分类号： C12Q1/02
CPC分类号： G01N33/57407 , A61K38/1793 , A61K38/20 , A61K2039/505 , C07K16/245 , G01N33/6869 , G01N2333/5412 , G01N2333/545
摘要： Diagnostic methods for the detection of multiple myeloma (MM) and the identification of high-risk patients with multiple myeloma-related plasma proliferative disorders, such as monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM), likely to progress to active MM are described. The diagnosis is based on the determination of concentrations of bioactive IL-1ß produced by bone marrow plasma cells of these patients. Also described are therapeutic methods for the treatment of MM and for the chemoprevention of the progression from disorders such as MGUS and SMM to active MM, involving the administration of inhibitors of IL-1ß.
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4.发明公开TRANSCOBALAMIN BINDING CONJUGATES USEFUL FOR TREATING ABNORMAL CELLULAR PROLIFERATION 审中-公开钴胺约束力偶联物治疗异常细胞增殖
公开(公告)号：EP1334114A2
公开(公告)日：2003-08-13
申请号：EP01989335.3
申请日：2001-10-25
CPC分类号： C07H23/00 , A61K47/551
摘要： An agent, composition and method for the treatment, prophylaxis and/or diagnosis of proliferative disorders, which is highly and efficiently absorbed at the site of abnormal cellular proliferation is disclosed.
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公开(公告)号：EP1284729A1
公开(公告)日：2003-02-26
申请号：EP01930491.4
申请日：2001-04-12
IPC分类号： A61K31/40 , A61K31/24 , A61K31/195 , A61K31/165
CPC分类号： G01N33/6896 , A61K31/165 , A61K31/192 , A61K31/195 , A61K31/24 , A61K31/40 , A61K49/0008 , G01N2500/00 , G01N2800/2821
摘要： The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ42 lowering agent to a mammal under conditions in which levels of Aβ42 are selectively reduced, levels of Aβ38 are increased, and levels of Aβ40 are unchanged. The invention provides methods and materials for developing and identifying Aβ42 lowering agents. In addition, the invention provides methods for identifying agents that increase the risk of developing, or hasten progression of, Alzheimer's disease. The invention also provides compositions of Aβ42 lowering agents and antioxidants, Aβ42 lowering agents and non-selective secretase inhibitors, as well as Aβ42 lowering agents and acetylcholinesterase inhibitors. The invention also provides kits containing Aβ42 lowering agents, antioxidants, non-selective secretase inhibitors, and/or acetylcholinesterase inhibitors as well as instructions related to dose regimens for Aβ42 lowering agents, antioxidants, non-selective secretase inhibitors, and acetylcholinesterase inhibitors.
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公开(公告)号：EP1108212A1
公开(公告)日：2001-06-20
申请号：EP99943950.8
申请日：1999-08-27
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/5091 , G01N33/6893 , G01N2800/324
摘要： The invention provides methods and materials for diagnosing an angina condition in a patient. Specifically, the invention provides methods and materials for classifying an angina condition as either stable or unstable. In addition, the invention provides methods and materials for determining an individual's predisposition to have a stable or unstable angina condition. The invention also provides kits for classifying an angina condition as either stable or unstable as well as kits for determining an individual's predisposition to have a stable or unstable angina condition.
摘要翻译： 本发明提供了用于诊断患者的心绞痛状况的方法和材料。 具体而言，本发明提供了用于将心绞痛病症分类为稳定或不稳定的方法和材料。 此外，本发明提供了用于确定个体倾向于具有稳定或不稳定的心绞痛症状的方法和材料。 本发明还提供用于将心绞痛病症分类为稳定或不稳定的试剂盒以及用于确定个体具有稳定或不稳定心绞痛病症的试剂盒的试剂盒。
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7.发明公开USE OF GENETICALLY ENGINEERED ANTIBODIES TO CD38 TO TREAT MULTIPLE MYELOMA 审中-公开使用遗传方式设计抗体CD38多发性骨髓瘤的治疗
公开(公告)号：EP1085882A2
公开(公告)日：2001-03-28
申请号：EP99927226.3
申请日：1999-06-04
CPC分类号： C07K16/2896 , A61K38/00 , A61K39/395 , A61K47/6849 , A61K2039/505 , C07K14/46 , C07K2317/24 , C07K2317/622 , C07K2319/00 , A61K2300/00
摘要： A fusion polypeptide comprising an antibody or a fragment thereof is provided. The fusion polypeptide is useful in a therapeutic composition to treat multiple myeloma.
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8.发明公开
公开(公告)号：EP1042349A1
公开(公告)日：2000-10-11
申请号：EP98953610.7
申请日：1998-10-16
发明人： RICHELSON, Elliott , TYLER, Beth, Marie , McCORMICK, Daniel, J. , CUSACK, Bernadette, Marie , HOSHALL, Clark, V. , DOUGLAS, Christopher, Lee , JANSEN, Karen
CPC分类号： C07K14/003 , A61K38/00 , A61K2123/00 , C12N15/1138 , C12N2310/3181
摘要： The invention provides methods of treating living cells with PNA oligomers such that the oligomers cross a biological barrier and engender a biological response. The invention provides methods for screening potential PNA oligomers for the ability to engender a sequence specific biological response. The invention also provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.
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9.发明公开COMBINATION OF AN ATP-COMPETITIVE INHIBITOR OF BCR/ABL KINASE ACTIVITY AND A TYRPHOSTIN ANALOG 有权联合BCR / ABL激酶的ATP COMPETITIVEN抑制剂和一酪氨酸磷酸化抑制剂模拟
公开(公告)号：EP1441717A1
公开(公告)日：2004-08-04
申请号：EP02783345.8
申请日：2002-10-25
发明人： KAUFMANN, Scott, H. , MOW, Benjamin
IPC分类号： A61K31/245 , A61K31/495 , A61P35/02
CPC分类号： A61K31/245 , A61K45/06
摘要： The present invention relates to a combination of (a) an ATP-competitive inhibitor of Bcr/abl kinase activity and (b) a tyrphostin analog, and the use of said combination or product for the treatment of bcr/abl-related diseases.
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公开(公告)号：EP1434596A1
公开(公告)日：2004-07-07
申请号：EP02802551.8
申请日：2002-10-09
发明人： CHEN, Lieping , STROME, Scott, E.
IPC分类号： A61K38/16 , A61K38/17 , A61K39/395
CPC分类号： A61K39/39 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K2039/505 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55516 , A61K2039/55522 , A61K2039/585 , C07K16/2878 , C12N2710/20034
摘要： This invention features methods of enhancing immune responses in mammalian subjects and in vitro methods of enhancing the response of a T cell. Also embodied by the invention are methods of receiving and preventing the induction of energy in T cells.
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