公开(公告)号：EP3349238B1

公开(公告)日：2021-09-01

申请号：EP16844489.1

申请日：2016-09-09

发明人： MIYAKE, Hideto

IPC分类号： H01L21/20 ,  C23C16/18 ,  C23C16/34 ,  C30B29/38 ,  H01L21/205 ,  H01L21/324

公开(公告)号：EP3081081B1

公开(公告)日：2018-05-23

申请号：EP14869059.7

申请日：2014-12-10

申请人： Mie University

发明人： ESTEBAN C. Gabazza ,  TAGUCHI, Osamu ,  KOBAYASHI, Tetsu

IPC分类号： A01K67/027 ,  C12N15/09 ,  C12N9/64 ,  C12N15/85

CPC分类号： A01K67/0278 ,  A01K67/027 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/035 ,  A01K2267/0368 ,  C12N9/6416 ,  C12N9/6491 ,  C12N15/09 ,  C12N15/8509 ,  C12N2015/8527 ,  C12N2830/15 ,  C12Y304/24024

摘要： [Problem to be solved] To provide a transgenic (TG) non-human mammal expressing human matrix metalloproteinase 2 (hMMP2) in whole body tissues, and a model animal developing COPD. [Solution] The objective is solved by development of an hMMP2-expressing TG non-human mammal characterized by the inclusion of a promoter to induce gene expression, and by the expression of the whole hMMP2 gene region placed on the downstream of the promoter that can induce systemic expression of the gene. The promoter for gene expression is preferably abeta-actin promoter, and the non-human mammal is preferably a mouse. Chronic obstructive pulmonary disease (COPD) can be induced by exposing the TG non-human mammal to inhalation of cigarette smoke extract.

公开(公告)号：EP2765193B1

公开(公告)日：2017-08-09

申请号：EP12838701.6

申请日：2012-10-05

申请人： Mie University ,  Takara Bio Inc.

发明人： SHIKU, Hiroshi ,  ORITO, Yuki ,  MINENO, Junichi ,  OKAMOTO, Sachiko ,  AMAISHI, Yasunori

IPC分类号： C12N15/09 ,  C07K14/705 ,  C07K19/00 ,  C12N5/10

CPC分类号： C12N15/85 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/70596 ,  C07K16/30 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/30

公开(公告)号：EP3053592A1

公开(公告)日：2016-08-10

申请号：EP14850811.2

申请日：2014-10-01

申请人： Mie University ,  Kyoto University

发明人： SHIKU, Hiroshi ,  HARADA, Naozumi ,  MURAOKA, Daisuke ,  AKIYOSHI, Kazunari

IPC分类号： A61K39/00 ,  A61K47/36 ,  A61K48/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07K14/00

CPC分类号： A61K39/0011 ,  A61K9/0019 ,  A61K39/015 ,  A61K39/12 ,  A61K47/36 ,  A61K2039/55583 ,  A61K2039/6087 ,  C12N2710/16122 ,  C12N2710/16134

摘要： The purpose of the present invention is to provide an interepitope sequence that effectively induces antigen presentation of each epitopes in a long-chain peptide antigen having a plurality of epitopes. A vaccine for the purpose contains a long-chain peptide antigen having a plurality of epitopes, said vaccine being characterized in that a sequence between the individual epitopes is one sequence selected from the group consisting of two to ten consecutive tyrosines, two to ten consecutive threonines, two to ten consecutive alanines, two to ten consecutive histidines, two to ten consecutive glutamines and two to ten consecutive asparagines. It is preferred that the vaccine is one selected from the group consisting of an anticancer vaccine, an antibacterial vaccine and an antiviral vaccine. It is also preferred that the vaccine is at least one selected from the group consisting of a peptide vaccine, a DNA vaccine, an mRNA vaccine and a dendritic cell vaccine.

摘要翻译： 本发明的目的是提供一种有效地诱导具有多个表位的长链肽抗原中每个表位的抗原呈递的相互联系的序列。 用于该目的的疫苗包含具有多个表位的长链肽抗原，所述疫苗的特征在于，各个表位之间的序列是选自二至十个连续酪氨酸，二至十个连续苏氨酸的一个序列 连续两至十次丙烯腈，连续二至十次组氨酸，连续二至十次戊二胺，连续两至十次天冬酰胺。 疫苗优选为选自抗癌疫苗，抗菌疫苗和抗病毒疫苗的疫苗。 还优选疫苗是选自肽疫苗，DNA疫苗，mRNA疫苗和树突状细胞疫苗中的至少一种。

公开(公告)号：EP1992688B1

公开(公告)日：2016-06-22

申请号：EP07714229.7

申请日：2007-02-15

申请人： Mie University

发明人： YOSHIMURA, Tetsuro ,  TSUMOTO, Kanta ,  IMAMURA, Kouji ,  MORINO, Kazuhiko ,  KOBAYASHI, Jun

IPC分类号： C12N15/00 ,  C12M1/00 ,  C12N15/09 ,  G01N33/549 ,  G01N33/564 ,  G01N33/58 ,  G01N33/68 ,  C12N15/866

CPC分类号： G01N33/5432 ,  C12N15/86 ,  C12N15/88 ,  C12N2710/14143 ,  C12N2810/855 ,  G01N33/564 ,  G01N33/56983 ,  G01N2333/01 ,  G01N2469/20

公开(公告)号：EP1965202B1

公开(公告)日：2016-04-13

申请号：EP08003378.0

申请日：2008-02-25

申请人： HORIBA, LTD. ,  Mie University

发明人： Nishio, Yuji ,  Iwamoto, Yasukazu ,  Tadanori, Hashimoto

IPC分类号： G01N27/36

CPC分类号： G01N27/36 ,  Y10T428/24999

公开(公告)号：EP1930433B1

公开(公告)日：2016-03-16

申请号：EP06797633.2

申请日：2006-09-07

申请人： Mie University ,  Takara Bio, Inc.

发明人： SHIKU, Hiroshi ,  HIASA, Atsunori ,  OKUMURA, Satoshi ,  NAOTA, Hiroaki ,  MIYAHARA, Yoshihiro

IPC分类号： C12N15/09 ,  A61K35/12 ,  A61K35/76 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C07K14/725 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10

CPC分类号： C07K14/705 ,  A61K35/12 ,  A61K38/00 ,  C07K14/7051 ,  C12N5/0636 ,  C12N2501/515 ,  C12N2510/00

公开(公告)号：EP2172547B1

公开(公告)日：2016-01-06

申请号：EP08777135.8

申请日：2008-06-10

申请人： Takara Bio Inc. ,  Mie University

发明人： MINENO, Junichi ,  OKAMOTO, Sachiko ,  SUMIOKA, Risa ,  KITAGAWA, Masanari ,  SHIKU, Hiroshi ,  KATO, Ikunoshin

IPC分类号： C12N15/09 ,  C12N5/10

CPC分类号： C07K14/7051 ,  C12N15/85 ,  C12N2800/40 ,  C12N2840/102

公开(公告)号：EP2497493A1

公开(公告)日：2012-09-12

申请号：EP10826901.0

申请日：2010-11-01

申请人： Mie University ,  Biocomo Co., Ltd. ,  National Institute of Biomedical Innovation

发明人： YASUTOMI, Yasuhiro ,  KAWANO, Mitsuo ,  NOSAKA, Tetsuya ,  FUKUMURA, Masayuki

IPC分类号： A61K39/04 ,  A61K35/76 ,  A61K39/00 ,  A61K48/00 ,  A61P31/06 ,  C12N15/09

CPC分类号： A61K35/76 ,  A61K39/04 ,  A61K2039/543 ,  C12N2760/18743

摘要： Disclosed is a intranasal spray-type tuberculosis vaccine, which has a high prophylactic effect on human tuberculosis, particularly adult tuberculosis. The nebulizable tuberculosis vaccine for intranasal administration comprises a paramyxovirus gene (particularly rhPIV2) having, integrated therein, a gene encoding an α antigen derived from an acid-fast bacterium (e.g., an α antigen derived from Mycobacterium kansasii or Mycobacterium bovis BCG), an analogue of the gene, or a variant of the gene which has an equivalent function to that of the gene.

摘要翻译： 公开了鼻内喷雾型结核疫苗，其对人类结核病特别是成人结核病具有高预防效果。 用于鼻内给药的可喷雾结核疫苗包括其中整合有编码来自抗酸细菌的±抗原的基因（例如，源自堪萨斯分枝杆菌或牛分枝杆菌BCG的±抗原）的副粘病毒基因（特别是rhPIV2），一种 基因的类似物，或与该基因具有等同功能的基因的变体。

公开(公告)号：EP2201095A1

公开(公告)日：2010-06-30

申请号：EP08855415.9

申请日：2008-11-27

申请人： Canon Kabushiki Kaisha ,  Mie University

发明人： MIYAZAKI, Takeshi ,  WATANABE, Kohei ,  TANAKA, Toshio ,  SHIMADA, Yasuhito ,  NISHIMURA, Norihiro

IPC分类号： C12M1/00 ,  C12M1/34 ,  C12M1/40 ,  C12M3/00 ,  C12N5/06 ,  C12Q1/02 ,  G01N21/64

CPC分类号： C12M21/06 ,  C12M23/12 ,  C12M25/01 ,  C12M25/06 ,  C12M35/08 ,  G01N21/6456 ,  G01N2021/0339 ,  G01N2021/0342 ,  G01N2021/0378 ,  G01N2021/174

摘要： Provide are a method of arranging a large number of living bodies such as cells, embryos, or individuals rapidly, individually, and one by one, a holding sheet for the method, and a device for processing the living bodies. The method of holding living bodies includes using a sheet in which multiple through-holes with a size capable of holding one of the target living bodies but not capable of holding two or more of the living bodies are provided, to thereby arrange and hold the living bodies one by one in the multiple through-holes in the sheet together with a liquid.