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公开(公告)号：EP2404997B1
公开(公告)日：2017-10-18
申请号：EP10748842.1
申请日：2010-03-05
申请人： Mie University , TAKARA BIO INC.
IPC分类号： C12N15/00 , A61K35/14 , A61P31/00 , A61P35/00 , A61P37/06 , C12N5/10 , C12N15/09 , A61K31/713 , A61K48/00 , C12N5/0783 , C12N15/113 , A61K35/12 , A61K35/17 , A61K39/00
CPC分类号： A61K35/17 , A61K2035/124 , A61K2039/5158 , C12N5/0636 , C12N15/113 , C12N2310/14 , C12N2501/48 , C12N2501/599 , C12N2310/531
摘要： Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases.
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公开(公告)号：EP2172547A1
公开(公告)日：2010-04-07
申请号：EP08777135.8
申请日：2008-06-10
申请人： Takara Bio, Inc. , Mie University
发明人： MINENO, Junichi , OKAMOTO, Sachiko , SUMIOKA, Risa , KITAGAWA, Masanari , SHIKU, Hiroshi , KATO, Ikunoshin
CPC分类号： C07K14/7051 , C12N15/85 , C12N2800/40 , C12N2840/102
摘要： Disclosed is a cell which can express a non-natural oligomeric protein, which has, introduced therein, a gene encoding an exogenous polypeptide corresponding to at least one endogenous polypeptide constituting a natural oligomeric protein, and in which the expression of the endogenous polypeptide is inhibited.
摘要翻译： 公开了一种可以表达非天然低聚蛋白的细胞，其中引入了编码对应于至少一种构成天然低聚蛋白的内源多肽的外源多肽的基因，并且其中内源多肽的表达被抑制 。
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公开(公告)号：EP2172547B1
公开(公告)日：2016-01-06
申请号：EP08777135.8
申请日：2008-06-10
申请人： Takara Bio Inc. , Mie University
发明人： MINENO, Junichi , OKAMOTO, Sachiko , SUMIOKA, Risa , KITAGAWA, Masanari , SHIKU, Hiroshi , KATO, Ikunoshin
CPC分类号： C07K14/7051 , C12N15/85 , C12N2800/40 , C12N2840/102
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公开(公告)号：EP2404997A1
公开(公告)日：2012-01-11
申请号：EP10748842.1
申请日：2010-03-05
申请人： Mie University , TAKARA BIO INC.
IPC分类号： C12N15/00 , A61K35/14 , A61P31/00 , A61P35/00 , A61P37/06 , C12N5/10 , C12N15/09 , A61K31/713 , A61K48/00
CPC分类号： A61K35/17 , A61K2035/124 , A61K2039/5158 , C12N5/0636 , C12N15/113 , C12N2310/14 , C12N2501/48 , C12N2501/599 , C12N2310/531
摘要： Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases.
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公开(公告)号：EP1225229B1
公开(公告)日：2011-10-19
申请号：EP00969984.4
申请日：2000-10-23
申请人： TAKARA BIO INC.
发明人： UENO, Takashi , MATSUMURA, Hajime , TANAKA, Keiji , IWASAKI, Tomoko , UENO, Mitsuhiro , FUJINAGA, Kei , ASADA, Kiyozo , KATO, Ikunoshin
CPC分类号： C12N15/86 , C12N2710/10343 , C12N2800/30
摘要： A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a sequence provided with adeno-associated virus-origin ITRs in both sides of the target foreign gene to be transferred, and a second nucleic acid, which has an adeno-associated virus-origin rep gene and a promoter for expressing this gene and carries a stuffer sequence inserted thereinto sandwiched in two recombinase recognition sequences and located between the rep gene and the promoter; and the step of expressing the Rep protein under the action of recombinase in the cells obtained in the above step to thereby integrate the target foreign gene into the chromosomal DNA.
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6.发明授权DRUGS, FOODS OR DRINKS WITH THE USE OF ALGAE-DERIVED PHYSIOLOGICALLY ACTIVE SUBSTANCES 有权药品，食品和饮料用生理活性物质从藻类
公开(公告)号：EP1038879B1
公开(公告)日：2009-04-01
申请号：EP98953005.0
申请日：1998-11-11
申请人： TAKARA BIO INC.
发明人： ENOKI, Tatsuji A-204, T.O Kopo Ishiyama , SAGAWA, Hiroaki 503, Hamoparesu Kusatsu , TOMINAGA, Takanari , NISHIYAMA, Eiji , KOYAMA, Nobuto , SAKAI, Takeshi 230, Raionzumanshon Shinagawamachi , YU, Fu-Gong , IKAI, Katsushige , KATO, Ikunoshin
IPC分类号： C07H3/10 , A23L3/3544
CPC分类号： A01N43/04 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A23L33/105 , A61K31/341 , A61K31/7048
摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1), foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.
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公开(公告)号：EP1067196B1
公开(公告)日：2009-02-18
申请号：EP99910758.4
申请日：1999-03-30
申请人： TAKARA BIO INC.
CPC分类号： C12P13/001
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公开(公告)号：EP1582587B1
公开(公告)日：2008-09-17
申请号：EP03778794.2
申请日：2003-12-11
申请人： TAKARA BIO INC.
发明人： TOMONO, Jun, 313, Hamoparesu-Kusatsu , UENO, Harumi, 609, Hamoparesu-Kusatsu , KISHIMOTO, Masayuki , SAGAWA, Hiroaki , KATO, Ikunoshin
IPC分类号： C12N15/31 , C12N15/63 , C12N15/67 , C12N15/70 , C07K14/245
摘要： A vector having a region encoding a cold shock protein gene mRNA-origin 5'-nontranslated region, characterized in that the 5'-nontranslated region has a mutation having been transferred therein so as to change the distance of the stem structure formed by the region.
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公开(公告)号：EP1947177A1
公开(公告)日：2008-07-23
申请号：EP06797712.4
申请日：2006-09-08
申请人： Takara Bio, Inc.
CPC分类号： C12N9/22
摘要： A novel endoribonuclease activity exhibiting polypeptide; a nucleic acid coding for the polypeptide; a recombinant DNA comprising the nucleic acid; a transformant obtained by transformation using the recombinant DNA; a process for producing the polypeptide, characterized by including the steps of culturing the transformant and collecting the polypeptide from the culture; a process for producing single-strand RNA fragments, characterized by including the step of causing the polypeptide to act on a single-strand RNA; and a method of fragmenting a single-strand RNA.
摘要翻译： 一种新的显示多肽的内切核糖核酸酶活性; 编码多肽的核酸; 包含该核酸的重组DNA; 通过使用重组DNA转化获得的转化体; 一种生产多肽的方法，其特征在于包括以下步骤：培养转化体并从培养物中收集多肽; 生产单链RNA片段的方法，其特征在于包括使多肽作用于单链RNA的步骤; 以及将单链RNA片段化的方法。
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公开(公告)号：EP1234568B1
公开(公告)日：2008-07-23
申请号：EP00979012.2
申请日：2000-11-29
申请人： TAKARA BIO INC.
发明人： MIZUTANI, Shigetoshi , DEGUCHI, Suzu , KOBAYASHI, Eiji , NISHIYAMA, Eiji , SAGAWA, Hiroaki , KATO, Ikunoshin
CPC分类号： A61Q19/10 , A61K8/60 , A61K8/73 , A61K8/9706 , A61K31/04 , A61K31/08 , A61K31/13 , A61K31/70 , A61K33/20 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/08 , Y10S514/88
摘要： To find a substance which has a skin cosmeticizing effect such as prevention of skin aging, amelioration of sensitive skin, or antipruritic action, and can serve as an effective ingredient for a hair-care product, thereby providing cosmetics comprising the effective ingredient. Concretely, there are provided cosmetics characterized in that the cosmetics comprise as an effective ingredient a compound selected from a fucoidan, a degradation product thereof, a sulfated monosaccharide or a salt thereof.
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